DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and nep-5

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001364754.1	Gene:	nep-5 / 173933	WormBaseID:	WBGene00017393	Length:	694	Species:	Caenorhabditis elegans

Alignment Length:	753	Identity:	149/753 - (19%)
Similarity:	262/753 - (34%)	Gaps:	202/753 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSLVAWLIFSLA-----------WRTTP-TACR-QTNAPQSVQEML--AEQLQSYMDTKARPCEN 53
            |.::..|||:|.           |...| .|.| ..:.|...:|.:  :.:|...||:...||||
Worm    69 LVILVLLIFALGALGLHDISAFKWEPKPQKALRIMLDLPCQTKECVKYSAELLELMDSSVNPCEN 133

  Fly    54 FYQYACGNWQIQQQEQHSLRDRDWTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFE 118
            |:.:.|..:        :.|.:|:.|..:....|..|       ||   ||...::||.......
Worm   134 FHHHVCNGF--------NPRKKDFERLMKLINIQEKP-------DH---RKAVNVVRRMLSKCAM 180

  Fly   119 SDSSILEQMRLYYRSCKRLKPYNLKKYLQLLPPSNSTQWPSVGRGW-RPERFDWITT-------- 174
            ..:..:.|:       .||...       :||   ...:|.:...| :|.  |.|:|
Worm   181 GKTEEIHQV-------GRLSSI-------ILP---GLPFPLLNNSWTKPS--DPISTSNSSTTYS 226

  Fly   175 -------LGRLRLH-----GLNGVLLREEVLPRWDDSRNYSIYVNKP----------------SR 211
                   |..:.||     |..|      :.|..|.  .:|::|.||                .:
Worm   227 YPFLTKILAHIILHNPDDAGFVG------IKPSSDS--EFSLFVVKPFSPVLTNFKFRNMYDILK 283

  Fly   212 QETQPMGEGAMIELLLDIGQTKRTANALARQVDDFERKLHRLQELEDDEGPREMQLGYLDSYLPQ 276
            :.........||:|..|          ..||::|..:...:|:::|....|..:.|..:...:|.
Worm   284 RNAPESSTNGMIDLEFD----------RQRQLNDVIKLQTKLEKIEFKADPEVVNLTEIQRQMPI 338

  Fly   277 LRWLSFMRQVRIDSEL-----DLRSTLIIENIPYLRALSDLMESESPDTVCSYIMLKW-LAFLKQ 335
            :.|...     |||.:     .|:..:...|..|...::.::.|...:|:.:::.|:: ..||:.
Worm   339 IDWKRL-----IDSWIPNGYAHLKEKVYGFNTSYYEEINAIISSTPSETIYNFLFLRFSFKFLRT 398

  Fly   336 QGPADISRGECVAALRRAMPLASSWLVGQQFSDPESESYVSSLFQRLKVRFGQILAENRMRLSPP 400
            :..:|: ...|:..|...:| ....|.|.:  :||:.:.::.:...:|.:..:.||..:. :...
Worm   399 EVASDL-EDTCLHQLSTTIP-GKIVLYGSE--EPEALNLLNGMLHTIKDQLKRSLATLKW-MDSR 458

  Fly   401 LVHILQQKLRAVRLQMGFFQTEEIEDVEQYHVRIDLSGHSFYGNQL--VLLRQRVEANHDLLYIN 463
            .:...|:|....:...||...:.|:::..     .::..|.|.:.|  |||.|.......:...|
Worm   459 GIEEAQKKFNKTKTVFGFTGEDLIDELVG-----KITPESNYISTLQNVLLWQTRNMFKSVAENN 518

  Fly   464 VTNFANSTGSNLSYLSESWEASNSSPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLA 528
            ||.|.                 ||...|...:|.:.:...||..|....|:......|.:...:.
Worm   519 VTVFL-----------------NSEVFYSVEKNEITISRALLHYPFMSANLPNYTNFATIASKIL 566

  Fly   529 HELAHGFDMLGMDYDAMGNIMG--PVEEIGASRQFRQGLQCLQQQMATGSKWIDEKLADFVALRL 591
            .::.|.||..|..||:.||...  ..|   ..|.|:..:||....|
Worm   567 PQMIHIFDERGRFYDSDGNHRNWWNTE---TERYFQIIVQCFDGMM------------------- 609

  Fly   592 AYETFFGVR---------DKREPRD--PLLPQFSQRQLFFITFAQFFCGRTPVLSPRSQSEAHLK 645
              :..|||.         ..:||..  |.:.|.|...|||.:..:..|
Worm   610 --QNVFGVSVSIGWNAYDSTKEPYATLPGIQQSSDEALFFYSMVKTMC----------------- 655

  Fly   646 HAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRI 683
             .:|...|.:.||:..:|:..|.|:...||....:|::
Worm   656 -TSDPDNVNEALASVPQFNSAFKCNNGTKMNPPTKCKL 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	137/700 (20%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	134/691 (19%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:417498	134/691 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166975
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.810