DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and nep-12

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001364537.1	Gene:	nep-12 / 173824	WormBaseID:	WBGene00017842	Length:	832	Species:	Caenorhabditis elegans

Alignment Length:	758	Identity:	166/758 - (21%)
Similarity:	283/758 - (37%)	Gaps:	181/758 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQQ-EQHSLRDRDWTRDRQRYQGQMLPTD 92
            |:.::  ||....:.|:..|.|||:||::|||.:..::. .:|..:                 ..
Worm   154 PECIR--LAASYLNNMNRDANPCEDFYEFACGKYATRKVIAEHEKK-----------------VT 199

  Fly    93 TLGLIDHSVNRKLELLLRRRNESSFESDSSILEQMRLYYRSCK---RLKPYNLKKYLQLLPPSNS 154
            .|..:...::|.|:.:|.:   :|.|:.:..::..::|:.||.   ......::..:.::  ||.
Worm   200 VLSEMKKEMDRHLKDILEK---TSRENTTRSMKLAQIYFDSCMDEFSQDDLGVQPLMSMI--SNL 259

  Fly   155 TQWPSVGRGWRPERFD-----WITTLGRLRLHGLNGVLLREEVLPRWDDS--------------R 200
            ..||.:...    |||     |....|.|.|:|::|: .|..|...:|||              .
Worm   260 GGWPLLTNA----RFDSIDFQWEVLAGHLALYGVDGI-FRVFVHSSFDDSDKNVLMFSPPKLFLE 319

  Fly   201 NYSIYVNKPSRQETQPMGEGAMIELLLDIG-QTKRTANALARQVD---DFERKLHRLQELEDDEG 261
            ....|...||...........::.||..:| ..:.....:..|||   ||||::..|..:|....
Worm   320 KKKFYREVPSSNVYLQYYRQYILSLLSLLGVDMEDETGVIEYQVDDIIDFERRIANLTRIELSRN 384

  Fly   262 PREMQ----LGYLDSYLPQLRWLSFMRQVRIDSELDLRSTLIIE--NIPYLRALSDLMESESPDT 320
            ...:.    .|.......::.|.:|..:....:...:..:|:|.  ::.|...|..|::|:...:
Worm   385 HSSINNMITFGEFKRKYDKINWDAFFNEEMRGNLGRMPDSLVINVVDVNYFDNLYSLIKSKPLSS 449

  Fly   321 VCSYIMLKW------------------LAFLKQQGPADISRGE-----CVAALRR--AMPLASSW 360
            :.:::|  |                  |.|  :|....:|..:     ||..:|.  ||||::.:
Worm   450 INNFLM--WCLVSNYDMYLPAKYRKPMLDF--RQKMYGVSSDDPLWEVCVGEVRENLAMPLSTEY 510

  Fly   361 LVGQQFSDPESESYVSSLFQRLKVRFGQILAENRMRLSPPLVHILQQKLRAVRLQMGFFQTEEIE 425
              .|:|...:.:.....:.:.||....|.|..         ...:.:..|...|
Worm   511 --AQKFFTKKDKLVAEDMIRDLKKAMEQTLLN---------ADWIDESTREAAL----------- 553

  Fly   426 DVEQYHVRIDLSGH------SFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEA 484
                  :::|..||      |......|||.          |..|...||....|...|.::...
Worm   554 ------MKLDAMGHKIGFPDSLLNETAVLLP----------YAGVRLTANQYFDNAISLKKAAYR 602

  Fly   485 SNSSPLYVRPR-------------------NLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHE 530
            ...|.|:..|.                   |.::.|.|:||.|::..:..|...:..:|..:.||
Worm   603 DALSKLHRTPSLIDWASPIIAVDAFHYFTGNEIIFPAGILQFPMFVPDAPAFSNYGAIGMGIGHE 667

  Fly   531 LAHGFDMLGMDYDAMGNIMG--PVEEIGASRQFRQGLQCLQQQMAT-----------GSKWIDEK 582
            :.||:|.||..||..||:.|  ..|.:   ..|::..||...|..:           |...|.|.
Worm   668 ITHGYDDLGAQYDDKGNLRGWWHTETM---TTFQKKKQCFVAQYGSKIEPQTGRKVDGKMTIGEN 729

  Fly   583 LADFVALRLAYETF--FGVRDKREPRDPLLPQFSQRQLFFITFAQFFCGRTPVLSPRSQSEAHLK 645
            :||...||:|::.:  ...|:|...|.|.|..||..||||:.:|..:|   ..|.|.:..  |:.
Worm   730 IADNGGLRVAFQAYQLRSDREKETRRLPGLTDFSPNQLFFLAYANTWC---EALKPSAID--HIM 789

  Fly   646 ----HAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
                |:....||...|.|...||:||.|...:.|...::||||
Worm   790 DTDVHSLGMFRVNVPLQNLPAFSKEFDCPIGSPMNPFEKCRIW 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	161/743 (22%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	158/735 (21%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	158/735 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880