DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and Mme

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_001276391.1	Gene:	Mme / 17380	MGIID:	97004	Length:	750	Species:	Mus musculus

Alignment Length:	793	Identity:	163/793 - (20%)
Similarity:	309/793 - (38%)	Gaps:	186/793 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKLSLVAWLIFSLAWRTTPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQ 65
            :|.|:::|..:.:|........|:.::..:|     |.:|...||....||.:|::||||.|
Mouse    35 VLLLTIIAVTMIALYATYDDGICKSSDCIKS-----AARLIQNMDASVEPCTDFFKYACGGW--- 91

  Fly    66 QQEQHSLRDRDWTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILEQMRLY 130
                  |:.........||....:..|           :||::|:...:.....|...:::.:..
Mouse    92 ------LKRNVIPETSSRYSNFDILRD-----------ELEVILKDVLQEPKTEDIVAVQKAKTL 139

  Fly   131 YRSC---KRLKPYNLKKYLQLLP-----PSNSTQW-PSVGRGWRPERFDWITTLGRLRLHGLNGV 186
            ||||   ..:.....:..|:|||     |..|..| .:.|..|..|:     ::.:|.......|
Mouse   140 YRSCINESAIDSRGGQPLLKLLPDIYGWPVASDNWDQTYGTSWTAEK-----SIAQLNSKYGKKV 199

  Fly   187 LLREEVLPRWDDSRNYSIYVNK-----PSRQETQPMG---EG--AMIELLLDIGQTKRTANALAR 241
            |:...|.....:|..:.|:.::     |||...:..|   |.  |.::.::.:.:..|...:|..
Mouse   200 LINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQSLPI 264

  Fly   242 QVDDFERKLHRLQELEDD--------EGPREMQLGYLDSYLPQLR-------------WLSFMRQ 285
            ..:....:::::.|||.:        |...:..|.|....|.:|:             |.:|..:
Mouse   265 DENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEVNGKSFSWSNFTNE 329

  Fly   286 VRIDSELDLRS--TLIIENIPYLRALSDLMESESPDTVCSYIMLKWLAFLKQQGPADISRG--EC 346
            :.....:::::  .:::....||..|..::...||..:.:.:..:::..|    .:.:||.  |.
Mouse   330 IMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDL----VSSLSRNYKES 390

  Fly   347 VAALRRAM----PLASSW-------------LVGQQFSDP----ESESYVSSLFQRLKVRFGQIL 390
            ..|.|:|:    ...::|             .||:.:.:.    ||:..|..|..:::..|.|.|
Mouse   391 RNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTL 455

  Fly   391 -------AENRMRLSPPLVHILQQ------------KLRAVRLQMGFFQTEEIEDVEQYHVRIDL 436
                   ||.:.:.....:.|.::            ||....|::.:.:.|..|::.| :::...
Mouse   456 DDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYREDEYFENIIQ-NLKFSQ 519

  Fly   437 SGHSFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEASNSSPLYVRPRNLVLVP 501
            |      .||..||::|:.:..:....|.|...|:|                      ||.::.|
Mouse   520 S------KQLKKLREKVDKDEWISGAAVVNAFYSSG----------------------RNQIVFP 556

  Fly   502 HGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQ 566
            .|:||.|.:....|....:..:|.|:.||:.||||..|.:::..|:::....:..|: .|:...|
Mouse   557 AGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSAN-NFKDQSQ 620

  Fly   567 CLQQQMA------------TGSKWIDEKLADFVALRLAYETFFGVRDKREPRDPLLP--QFSQRQ 617
            |:..|..            .|...:.|.:||...:..||..:... .|:...:.|||  ..:.:|
Mouse   621 CMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNY-VKKNGEEKLLPGLDLNHKQ 684

  Fly   618 LFFITFAQFFCG-----------RTPVLSPRSQSEAHLKHAADELRVMQTLANFEEFSREFGCDK 671
            |||:.|||.:||           :|.|            |:....|::.||.|..||:..|.|.|
Mouse   685 LFFLNFAQVWCGTYRPEYAVNSIKTDV------------HSPGNFRIIGTLQNSAEFADAFHCRK 737

  Fly   672 KAKMQASQRCRIW 684
            .:.|...::||:|
Mouse   738 NSYMNPERKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	154/750 (21%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	150/742 (20%)
Mme	NP_001276391.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_001276391.1	M13	77..748	CDD:341056	150/742 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920