DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and nep-11

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_494538.1	Gene:	nep-11 / 173685	WormBaseID:	WBGene00017557	Length:	848	Species:	Caenorhabditis elegans

Alignment Length:	770	Identity:	167/770 - (21%)
Similarity:	298/770 - (38%)	Gaps:	184/770 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRY 84
            |..|   :.|..|:  .|....:.|:|...||::|:::|||.|    .:||.:.|
Worm   158 PEVC---STPGCVR--AATHFLNAMNTSVDPCDDFFEFACGQW----NDQHPIPD---------- 203

  Fly    85 QGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILEQMRLYYRSCKRLKPYNLKKYLQLL 149
              .|....|.......|.::|.:||    |....::|..:...|..||||     .|..:..:|:
Worm   204 --DMYGFGTFAYAREQVRQQLRVLL----EQEVVTESESINMARATYRSC-----MNKTQLDELM 257

  Fly   150 P-PSNST-----QWPSVGRGWRPERFDWITTL-GRLRLHGLNGVLLREEVLPRWDDSRNYS---I 204
            . |...|     :||.:...|...:|::.:.| ...|.:|:: |..:   |..:.||:|.|   :
Worm   258 TGPLFETLTELGEWPLLQENWDKTKFNFTSLLVNSRRDYGVD-VFFQ---LYIYADSKNTSRNTL 318

  Fly   205 YVNKPSRQETQPMGEGA-----------------------MIELLLDIGQTKRT---ANALARQV 243
            :::    |.|..:|.|.                       :..||...|...|:   .||...::
Worm   319 FID----QSTLALGRGTRDYYLNTTLFSSHMTAYRKYLRQIAHLLKTDGNLTRSESEMNADIEKI 379

  Fly   244 DDFERKLHRLQELEDDE-------GPREMQLGYLDSY--LPQLRWLSFMRQVRIDSELDL----- 294
            .|||.:|.::...||:.       ..|::|    |.|  |||:.|:.|.:.:   :..||
Worm   380 IDFEIELAKIIVAEDERRNNTRLYNKRQIQ----DLYNLLPQVDWVPFFQSI---APSDLTHLFH 437

  Fly   295 -RSTLIIENIPYLRALSDLMESESPDTVCSYIM-------LKWL---------AFLK-----QQG 337
             .:.:||..|.||:.:|:|:|......:.:|::       :::|         .|||     ||.
Worm   438 NETEIIICEIEYLQHVSELIEKTDVGLLTNYVLWRVVQSNVRYLDERFEDIKQDFLKVMTGQQQS 502

  Fly   338 PADISRGECVAALRRAMPLASSWLVGQQFSDPESESYVSSLFQRLKVRFGQILAENRMRLSPPLV 402
            |....  :|.......:|||:..:..|.......:.....:...|:..|..::.:|..
Worm   503 PPRWK--DCAQVPSTVLPLAAGAIYVQAHFQESDKHEALRMIMHLRNSFADLVRQNDW------- 558

  Fly   403 HILQQKLRAVRLQMGFFQTEEIEDVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTNF 467
              :.::.:||.             :|:.:..|:..|:....|.|..|        |..|:.::..
Worm   559 --MDEETKAVA-------------IEKANSMINNIGYPDVTNDLPKL--------DKQYLGLSIS 600

  Fly   468 ANSTGSNLSYLSESWEASNS---------------SP-----LYVRPRNLVLVPHGLLQLPIWHR 512
            .:.|...:...|..|..|..               ||     .|...:|.:..|.|:||.|.:..
Worm   601 DSDTYYYIMKKSVVWMQSREFQKLTKPFDKHEFDISPAVVNAFYSPEKNAITFPAGILQPPFFSG 665

  Fly   513 NISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQ------ 571
            .......:..:|.|:.||:.||||..|..||..||:.....| .:...|....:|:.:|
Worm   666 TFPKAVNYGAIGAVIGHEITHGFDDQGSQYDKDGNLHNWWSE-SSLNSFDTRRRCIVEQYGNYTV 729

  Fly   572 -----MATGSKWIDEKLADFVALRLAYETF--FGVRDKREPRDPLLPQFSQRQLFFITFAQFFCG 629
                 ...|.....|.:||...::.|::.:  :...:..|||.|.|.|::..|:||:::|.|:||
Worm   730 PKTNFRVNGKLTQGENIADNGGVKEAFQAYQKYVTENGEEPRLPGLQQYTNEQIFFVSYAHFWCG 794

  Fly   630 RTPVLSPRSQSEAHLKHAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
            :....:...|.... :|:.:..||:..|:|.:.|:..:.|.:.|.:....:|.:|
Worm   795 KKKEAAAMQQVLTD-EHSPEVFRVIGVLSNMQAFADVYKCPRNAPVNPDHKCIVW 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	161/746 (22%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	158/738 (21%)
nep-11	NP_494538.1	PepO	174..848	CDD:226118	161/747 (22%)
nep-11	NP_494538.1	M13	181..845	CDD:189000	158/737 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020