Protein Alignment Nepl5 and nep-10

DIOPT Version :9

• Sequence 1: NP_609022.1
• Gene: Nepl5 / 33892
• FlyBaseID: FBgn0031808
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_494532.2
• Gene: nep-10 / 173684
• WormBaseID: WBGene00017555
• Length: 711
• Species: Caenorhabditis elegans
• Alignment Length: 744
• Identity: 146/744 - (19%)
• Similarity: 278/744 - (37%)
• Gaps: 171/744 - (22%)

  Fly    18 TTPTACRQTNAPQSVQE-----MLAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDW 77
            |..:..:..:.|::|.|     .||.:|.:|.|....||::|||:.||.:.     :||...
 Worm    62 TIDSETQTVDEPRNVCESPECITLAHELHNYKDPSVDPCQDFYQHFCGKFY-----EHSAIG--- 118

  Fly    78 TRDRQRYQGQMLPTDTLGLIDHSVNRKL--ELLLRRRNESSFESDSSILEQMRLYYRSCKRLKPY 140
                   ||:|       ....|...||  |.||:.:..:| :|:::    |:..|..|:.|:..
 Worm   119 -------QGRM-------ATKRSTLSKLIREFLLKNKTSTS-KSENT----MKQVYAKCRELQKI 164

  Fly   141 NLKKYLQLLPP----------SNSTQWPSVGRGWRPERFD------WITTLGRLRLHGLNGVLLR 189
            :   .|..:||          .....||.:.:.|...:|:      .:..||...|...:...:
 Worm   165 S---DLNSIPPQALLDIFSDIKKIGAWPVLDKDWDGSKFNLNEMLRQLVNLGETHLGFFHFDFI- 225

  Fly   190 EEVLPRWDDSRNYSIYVNKPSRQETQPMGEGAMIELLLDIGQTKRTANALARQVDDFERKLHRLQ 254
                     :|.| :.:..|.:|..|......:::::|:..:.|.. ...:..:|::....:|
 Worm   226 ---------ARPY-VLIKPPLKQGVQKSVLEKVVKMILEANEIKMD-QGFSEDLDEYFELSNR-- 277

  Fly   255 ELEDDEGPREMQLGYLDSYLPQLRWLSF-------MRQVRIDSELDLRSTLIIENIPY------- 305
             ::.|:.||..:  .:...||.:|.::|       |.:.:::..|   .||..:.:.|
 Worm   278 -IKIDKLPRTSR--SIVGLLPDVRRINFRGLILEMMPRSKMNRFL---GTLFQKVVTYHHPLFVR 336

  Fly   306 ---LRALSDLMESESPDTVCSYIM-------LKWLAF-LKQQGPADISRGECVAALRRAMPLASS 359
               ...|..::.|.|...:.:|::       :|:|.| ||.      .|..|...:.:.:|..|.
 Worm   337 DNETNHLDTIIRSTSNRALANYLIFNFIHSSIKFLTFGLKS------DRERCEKIVVQELPRPSL 395

  Fly   360 WLVGQQFSDPESESYVSSLFQRLKVRFGQILAENRMRLSPPLVHILQQKLRAVRLQMGF---FQT 421
            .:..:...|..:...|:.|.:.:|....:::.|:. ..:|.:...:.:|:.|:...:|:   |..
 Worm   396 RVFMRNCVDKGNREEVAKLTETVKENVLEMIRESD-SFTPSVKKRVLKKVEAIGAIIGYPDHFDP 459

  Fly   422 EEIEDVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEASN 486
            ....|.|..::.:|.| .|:|.....|.:.|::  |.:.::     |..|.     ||.|.:...
 Worm   460 PGTLDKEYENLTLDAS-DSYYKMSQKLHQLRLQ--HQMEFL-----AGQTP-----LSPSDQVLE 511

  Fly   487 SSPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGP 551
            .:..|....|.:.|....|..|.:.............||::.||..|..|...:..|....
 Worm   512 VNAHYDSKDNALTVLAPFLDDPFFDSTYPEYVNLIFTGFLIGHEFGHSIDPKILRRDGWYK---- 572

  Fly   552 VEEIGASRQFRQGLQCLQQQ-----------MATGSKWIDEKLADFVALRLAYETF--------- 596
            .|::   .::.:..|||..|           ...|:..|.|.:.|:|...:.:..|
 Worm   573 TEDM---TEYGKRAQCLIDQYDNYDDPDHGKQMNGTYCIGEIVGDWVGRDVTWRAFKKMDLSKMQ 634

  Fly   597 --FGVRDKREPRDPLLPQFSQRQLFFITFAQFFCGRTPVLSPRSQSEAHL----KHAADELRVMQ 655
              .|..||           :..||:|...:.||||      |||......    .|..:..||..
 Worm   635 KLIGFEDK-----------NLDQLYFRIQSLFFCG------PRSMKSLEQLLSDPHPTEVFRVNG 682

  Fly   656 TLANFEEFSREFGCDKKAKMQASQRCRIW 684
            ..:|..:|::.|.|...:.|...::|:::
 Worm   683 IYSNMPQFAKAFNCPIGSPMNPEKKCKMF 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	139/713 (19%)
		GluZincin	48..682	CDD:301352	136/705 (19%)
nep-10	NP_494532.2	M13	97..709	CDD:189000	136/705 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920