DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and nep-9

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_494531.2	Gene:	nep-9 / 173683	WormBaseID:	WBGene00017554	Length:	700	Species:	Caenorhabditis elegans

Alignment Length:	743	Identity:	157/743 - (21%)
Similarity:	285/743 - (38%)	Gaps:	175/743 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RTTPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDR 81
            |.||..|   .:||.:  :||::|::|.||..:.||:||:..|.|:     :.|...||.  ||.
Worm    58 RVTPQFC---ESPQCI--ILAQELKAYSDTATKSCEDFYKATCENY-----KDHQALDRH--RDC 110

  Fly    82 QRYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILEQMRLYYRSCKRLKPYNLKKYL 146
            ::.:              :||:.:...| :|:||:|.|:|.  ..::|.:..|..|.  ....||
Worm   111 KKRK--------------AVNKLVRGFL-QRDESTFTSESE--SAIKLIFGKCDELS--RNTSYL 156

  Fly   147 QLLPPSNST-QWPSVGRGWRPERF---DWITTLGRLRL--HGLNGVLLREEVLPRWDDSRNYSIY 205
            .:....... .||.:...|:...|   |.|..|.:|..  .||..:.||:...      .:::::
Worm   157 DIFKDIKKIGSWPVLEHNWKDSMFNLDDVIAKLVKLGSTDFGLFKLELRKLAF------GHFAVF 215

  Fly   206 VNKPSRQETQPMGEGAMIELLLDIGQTKRTANALARQVDDFERKLHRLQELEDDEGPREMQLGYL 270
            |:....|....: |..::.:|...| .::....|:..:.|:....:.|:|...:|...|.:| |.
Worm   216 VSSKQEQNIHQL-EKTILGILKANG-IQQDRKELSDDLKDYSDFKNHLKEFYQEETYIEYRL-YA 277

  Fly   271 DSYLPQLRWLSFMRQVRIDSE-LDL-----RSTLIIENIPYL---RALSDLMESESPDTVCSYIM 326
            .|.:..|...|...|:.:.|. ||:     :.|||..:..:.   ..|..:::.....|:.::::
Worm   278 GSIVENLGISSLTTQMALKSTGLDVFNHVNQRTLITNSSLFFGEENNLGMIIQKTPKRTLANFLI 342

  Fly   327 LKWLAFLKQQGPADISRG--ECVAALRRAMPLASSWLVGQQFSDPESESYVSSLFQRLKVRFGQI 389
            ..::..:    ..|::..  .|...|...:|.||..::.:.|.:.:::..:..:.|.||.:..::
Worm   343 FHFIDVM----TTDLANATKACKETLIDLLPRASIQVLSRNFVNEDAQDDMVKMAQDLKTKITEM 403

  Fly   390 L--------------AENRMRLSPPLVHILQQKLRAVRLQMGFFQTEEIEDVEQYHVRIDLS-GH 439
            :              ||.:.:|.        ||::|:.:...:.|.....|.|    |::|: ..
Worm   404 IDNSPFFTKFHLVFDAEEQKKLI--------QKVKAIGIVTEYPQEVLDRDFE----RLNLTPSD 456

  Fly   440 SFYGNQLVLLRQRVE--------------------ANHDLLYINVTNFANSTGSNLSYLSESWEA 484
            |.|.....|.|.|.|                    |::|....|:|.||.....  .|...|:
Worm   457 SIYRTIQKLRRLRSEQLIEHLGGDLDPTDTRVWGSAHYDQTTNNLTIFAPIIDG--PYFDTSY-- 517

  Fly   485 SNSSPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMG--- 546
                |.||                          ...:|||:|..||....|.:.:..|..|
Worm   518 ----PNYV--------------------------NQFLMGFILGRELGRSLDSVRIRKDEKGQTE 552

  Fly   547 NIMGPVEEIGASRQFRQGLQCLQQQ-------MATGSKWI---------DEKLADFVALRLAYET 595
            |.:.| |.:   ::|.:.|:|..::       :.:.||.|         :|..|||:....::..
Worm   553 NWLKP-ESL---KRFDEHLKCWAEKYDKSADPLKSESKGIRQIEGRYIQNEMFADFIGHEASWRA 613

  Fly   596 FFGVRDKREPRDPLLPQFSQRQLFFITFAQFFC----GRTPVLSPRSQSEAHLKHAADELRVMQT 656
            |..:..|.|...........|::||...|.:||    |.|..||    .:.|.:|.:  .||...
Worm   614 FMKLDVKNEEVLETFKVIKLRRMFFNVQALYFCRPPSGSTDWLS----YQEHHQHYS--FRVNGA 672

  Fly   657 LANFEEFSREFGCDKKAKMQASQRCRIW 684
            ..|..:|:..|.|.....|....:|.::
Worm   673 FKNMPQFALAFECASDDDMNPQNKCSMF 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	148/716 (21%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	144/708 (20%)
nep-9	NP_494531.2	M13	87..698	CDD:189000	144/705 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12569
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860