DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl5 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_055508.3	Gene:	EEF1AKMT4-ECE2 / 110599583	HGNCID:	53615	Length:	883	Species:	Homo sapiens

Alignment Length:	724	Identity:	154/724 - (21%)
Similarity:	290/724 - (40%)	Gaps:	135/724 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRY-QGQMLPTDTLGLIDH 99
            :|.::...:|....|||:|||::||.| |::......|.| |......: |.|.:
Human   220 VAGKILESLDRGVSPCEDFYQFSCGGW-IRRNPLPDGRSR-WNTFNSLWDQNQAI---------- 272

  Fly   100 SVNRKLELLLRRRNESSFESDSSILEQMRLYYRSCKRLK------------------------PY 140
                 |:.||   ..::|.|.|...::.:.:|.||.:::                        |:
Human   273 -----LKHLL---ENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPW 329

  Fly   141 NLKKYLQLLPPSNSTQWPSVGRGWRPERFDWITTLGRLRLHGLNGVLLREE--VLPRWDDSRNYS 203
            :...::::|        .:|...:|...|..:......:....|.:.:.:.  .||    ||:|
Human   330 DQDNFMEVL--------KAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLP----SRDY- 381

  Fly   204 IYVNKPSRQETQPMGEGAMIELLLDIGQTKRTANALARQVDDFERKLHRL-----QELEDDEGPR 263
             |:|:.:.::........|.||.:.:|....:.....:||.:.|.:|..:     |..::::...
Human   382 -YLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYH 445

  Fly   264 EMQLGYLDSYLPQLRWLSFMRQVRIDSELDLRSTLIIENIPYLRALSDLMESESPDTVCSYIMLK 328
            :|.:..|.:..|.:.||.|:..:....||.....:::..:.||:.:|:|:....|..:.:|::
Human   446 KMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLI-- 508

  Fly   329 WLAFLKQQGPAD---------------------ISRGE-CVAALRRAMPLASSWLVGQQFSDPES 371
            |....|.....|                     :.|.: |::....|:..|...|..:...|.:|
Human   509 WNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQS 573

  Fly   372 ESYVSSLFQRLKVRFGQILAENRMRLSPPLVHILQQKLRAVRLQMGF----FQTEEIEDVEQYHV 432
            :.....:...::..|.:.|.: .:.:........::|..|:...:||    .:.:|::||...:
Human   574 KEIAEGMISEIRTAFEEALGQ-LVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGY- 636

  Fly   433 RIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEASNSSP-----LYV 492
              ::|..||:.|.|                |:.||:....::......|.:..:.:|     .|:
Human   637 --EISEDSFFQNML----------------NLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYL 683

  Fly   493 RPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGA 557
            ..:|.::.|.|:||.|.:.||.........:|.|:.|||.|.||..|.:||..||:. |..:..:
Human   684 PTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLR-PWWQNES 747

  Fly   558 SRQFRQGLQCLQQQ---------MATGSKWIDEKLADFVALRLAYETFFG-VRDKREPRDPLLPQ 612
            ...||....|:::|         ...|.:.:.|.:||...|:.||..:.. :|...|.:......
Human   748 LAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVG 812

  Fly   613 FSQRQLFFITFAQFFCGRTPVLSPRSQSEAHL--KHAADELRVMQTLANFEEFSREFGCDKKAKM 675
            .:..||||:.|||.:|.   |.:|.|..|..:  .|:....||:.||:|..:|.|.|||...:.|
Human   813 LTNHQLFFVGFAQVWCS---VRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPM 874

  Fly   676 QASQRCRIW 684
            ...|.|.:|
Human   875 NPGQLCEVW 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	152/716 (21%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	150/708 (21%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160
		Methyltransf_25	62..>128	CDD:316196
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	88..89
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	113..114
		M13	232..881	CDD:189000	150/708 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920