DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and mme

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_031758820.1	Gene:	mme / 101734885	XenbaseID:	XB-GENE-1011098	Length:	746	Species:	Xenopus tropicalis

Alignment Length:	820	Identity:	165/820 - (20%)
Similarity:	296/820 - (36%)	Gaps:	230/820 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKLSLVAWLIF--------SLAWRT------TPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCE 52
            |:..|:...||        .||:.|      |..||..|          |.::.:.||....||.
Frog    20 LEKGLIILCIFLGIISIAMILAYATSNDGICTSQACIST----------AARIIANMDAATDPCN 74

  Fly    53 NFYQYACGNWQIQQQEQHSLRDRDWTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSF 117
            :|||||||.|                ..:.|.....:.::|..::    ...:|::|:...|...
Frog    75 DFYQYACGGW----------------LKKNRIPDNNIVSNTFDIL----RTDIEVVLKDALEKES 119

  Fly   118 ESDSSILEQMRLYYRSCKRLKPYNLKK---YLQLLPPSNSTQWPSVGRGWRPERFD--W------ 171
            ..|...:::::.:|:||......||:|   .::.||.  ...||.....|. .|:.  |
Frog   120 ADDIPAIKKVKTFYKSCIDETIKNLRKGGPLIKTLPA--LYDWPIAVDNWE-TRYGLVWSAQESI 181

  Fly   172 ---ITTLGRLRLHGLNGVLLREEVLPRWDDSRNYSIYVNKPSR----------QETQPMGEGAMI 223
               ||..|:   .||..|.:.|::    .:|..|.:::::|..          :.|..:...|.:
Frog   182 AGFITKYGQ---SGLINVYVSEDL----TNSSTYILHIDQPGLGLPSKDYYDCKGTSEIACLAYM 239

  Fly   224 ELLLDIGQTKRTANALARQVDDFERKLHRLQELEDD----EGPREMQLGYLDSYLPQ-LRWLSFM 283
            |.::.:....|....|....|....::.::.:||.:    |...|::....|.|... |..::..
Frog   240 EQMVSVAMLIRKERNLTINEDKILSEMEKVFKLEREIAKAEASEEIRENLNDIYKKMTLSGIAKT 304

  Fly   284 RQVRIDSELDLRSTLIIENIPYLRALSDLM--------ESESPDTVCSYIMLK------------ 328
            ..::::.          :||.:|:.::.::        |:|....:||..:.|
Frog   305 YPLKMND----------QNINWLKLINAIISPGGVSIEENEQVALICSDYLKKLRFLNKYKAREL 359

  Fly   329 -----WLAFLKQQGPADISRGECVAALRRAM----PLASSWLVGQQFSDPESESYVSSLF----- 379
                 |...|.......:........|::|:    ...|.|.....:.:...|..:..|:
Frog   360 QNYLGWRYILSAINDLSLEYKNTGIHLKKALYGNAAEGSDWQTCVTYLNDNMEDAIGRLYLKETL 424

  Fly   380 ------QRLKVRFGQILAENRMRLSPPLVHILQQ--------KLRAVR----------------- 413
                  .::|.:..:|:||.|.    ..:.:|::        |.||.|
Frog   425 SADIEHVKVKDKVKEIIAEIRR----AFLEMLEEMDWMDEDTKKRAARKVASINERIAFSEDIMD 485

  Fly   414 ---LQMGF----FQTEEIEDVEQYHVRIDLSGHSFYGNQLV-LLRQRVEANHDLLYINVTNFANS 470
               |..|:    |:.:|:.:.:|.::       .|...::. .||::|..|
Frog   486 DFKLNEGYSELEFRVDELFENKQKYI-------EFVQKKMTSRLRKQVNKN-------------- 529

  Fly   471 TGSNLSYLSESW--EASNSSPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAH 533
                      .|  ..::.:..|....|.::.|.|:||.|.:..:..:...:..:|.::.||:.|
Frog   530 ----------EWVPGPAHVNAFYSLTYNEIVFPAGILQTPFFSSSQPSALNYGGIGMIIGHEITH 584

  Fly   534 GFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQMA------------TGSKWIDEKLADF 586
            |||..|.::|..||::..... .:...|....||...|..            .|...:.|.::|.
Frog   585 GFDNRGCNFDEHGNLVNWWTN-ASMMNFSNLSQCFVNQYGNYSWDEAGGQYLNGISTLGENISDN 648

  Fly   587 VALRLAYETFFG-VRDKREPRDPLLP--QFSQRQLFFITFAQFFCGRTPVLSPRSQSEAHL---- 644
            ..:|.||..|.. |:..:|  |.|||  .....|||||:|.|.:||     ..|.:..|.|
Frog   649 GGIRGAYRAFKNYVKSHKE--DDLLPGIDLDSDQLFFISFGQIWCG-----MHRPEYAATLIKTG 706

  Fly   645 KHAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
            .|.....||:.||.|..|||:.|.|...|.|..:.:|::|
Frog   707 SHTPGIFRVIGTLQNSPEFSKAFSCCNNAYMNPAVKCKLW 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	152/764 (20%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	149/756 (20%)
mme	XP_031758820.1	M13	71..744	CDD:341056	149/755 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020