DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl5 and phex

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_004911718.1	Gene:	phex / 100496470	XenbaseID:	XB-GENE-1012247	Length:	750	Species:	Xenopus tropicalis

Alignment Length:	759	Identity:	179/759 - (23%)
Similarity:	317/759 - (41%)	Gaps:	169/759 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRYQGQMLPTDT 93
            |:.::  .|..::|.|:....||::|:|||||.|    .|::.:.|     |...|
Frog    58 PECIE--AAASIRSKMNLSVDPCDDFFQYACGGW----IEENPIPD-----DMSNY--------- 102

  Fly    94 LGL---IDHSVNRKLELLLRRRNESSFESDSSILEQMRLYYRSC---KRLKPYNLKKYLQLLPPS 152
             |:   :..:|:.||:.||.:  ..|...||..:::::.:|.||   .:::..::|..|::| ..
Frog   103 -GIYPWLRTNVDLKLKALLEK--PISKRRDSEAIQKVKTFYISCMNETQIEEDDIKPILKIL-KQ 163

  Fly   153 NSTQWP-------SVGRGWRPERFDWITTLGRLRLHGLNGVLLREEVLPRWDD--SRNYSIYVNK 208
            .|.:||       |.|: |...:|.::.|:..||......|.||  |....||  |.|:.:.:::
Frog   164 PSLRWPVLESNIGSDGK-WSERKFSFLQTVADLRRLYSTSVFLR--VYVAIDDKVSNNFILKLDQ 225

  Fly   209 PS-----------RQETQPMGEGAMIELLLDI----GQTKRTANALARQVDDFERKLHRL---QE 255
            .|           ..........|::|.::|:    |..|..|....:.:.:.|.||.::   ||
Frog   226 ASLSLLSHEDYLDNSTIAKKYRDALLEFMVDVAVLLGANKTRAETDMKALIELETKLAQITVPQE 290

  Fly   256 LEDDEGP-REMQLGYLDSYLPQLRWLSFMRQVRID-------SELDLRSTLIIENIPYLRALSDL 312
            ....|.. .:|.:..|.:.:||..|||:::.: ||       ..:||...:|:....:.:.|.::
Frog   291 NRTSEMMYNKMNISELSAMIPQFDWLSYLKNI-IDFNIYPELKNIDLSENVIVRVPQHFKDLFNI 354

  Fly   313 MESESPDTVCSYIMLKW-LAFLK--------QQGPADISR------------GECVAALRRAMPL 356
            :|||...|:.:|::  | |.:.:        |....:.:|            ..||..:..::|
Frog   355 IESEEKRTLANYLI--WRLVYSRIPNLSRRFQYRQLEFARILLGTNSLAGRWDRCVNYVENSIP- 416

  Fly   357 ASSWLVGQQFSD----PESESYVSSLFQRLKVRFGQIL--------AENRMRLSPPLVHILQQKL 409
               :.||:.|.|    .:.:..:..|...::..|..:|        ||.:::        .:||.
Frog   417 ---YPVGKLFVDAHFQEDKKDMMEELVDGIRWAFIDMLEKENDWMDAETKIK--------AKQKA 470

  Fly   410 RAVRLQMG-----FFQTEEIEDVEQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTN--- 466
            ..|..::|     |..|...||::.    :..|...::||.|..|....:::...|..||..
Frog   471 VTVMAKVGYPEFLFNDTYLNEDIKM----LKFSESDYFGNVLQTLHFISQSDFYWLRRNVPKKEW 531

  Fly   467 FANSTGSNLSYLSESWEASNSSPLYVRPRNLVLVPHGLLQLP-IWHRNISALQQHAVMGFVLAHE 530
            |.|.|..|..|.:.:              |.:..|.|.||.| .|.........:..:|.::.||
Frog   532 FTNPTTVNAFYSAST--------------NQIRFPAGELQKPFFWGVQYPRSLSYGAIGVIVGHE 582

  Fly   531 LAHGFDMLGMDYDAMGNIM----GPVEEIGASRQFRQGLQCLQQQM-----------ATGSKWID 580
            ..||||..|..||..||:.    ...||     :|:....|:.:|.           ..|.|.:.
Frog   583 FTHGFDNNGRKYDKEGNLFSWWTSESEE-----RFKNKTLCMVEQYNNYYWKQAGLHVKGMKTLS 642

  Fly   581 EKLADFVALRLAYETF-FGVRDKREPRDP-LLP--QFSQRQLFFITFAQFFCGRTPVLSPRSQSE 641
            |.:||...:|.::..: ..:.|.|:.::. |||  ..:..|||||::|...|....:.|.|.|..
Frog   643 ENIADNGGIRESFRAYRKWIEDLRKGKEEMLLPGLDLNNNQLFFISYAHVRCNSFRIESARDQIM 707

  Fly   642 AHLKHAADELRVMQTLANFEEFSREFGCDKKAKM-QASQRCRIW 684
            ..: |:..:.||:..::|||||.:.|.|.|.:|| :.:..||:|
Frog   708 NGV-HSPPQFRVIGAMSNFEEFHKAFSCPKDSKMNRGANSCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	176/744 (24%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	172/736 (23%)
phex	XP_004911718.1	M13	75..741	CDD:341056	171/729 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010