DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl5 and LOC100332538

DIOPT Version :9

Sequence 1:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	XP_021322193.1	Gene:	LOC100332538 / 100332538	-ID:	-	Length:	808	Species:	Danio rerio

Alignment Length:	811	Identity:	179/811 - (22%)
Similarity:	317/811 - (39%)	Gaps:	217/811 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KLSLVAWLIFS---------------LAWRTTPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCE 52
            ::.|::.|:|:               |..|:..:.|||....:......|..:|..:|...:||.
Zfish    86 EICLLSALVFAAGMCVILGCMLALKFLXARSQDSQCRQDCVKRRSLLRAARFVQGNIDPSVQPCH 150

  Fly    53 NFYQYACGNWQIQQQEQHSLRDRDWTRDRQRYQGQMLPTDTLGLI-------DHSVNRKLELLLR 110
            :||.:|||.|         ||......|:..|          |:|       ...:.|.|:..::
Zfish   151 DFYSFACGGW---------LRRHGIPEDKLSY----------GIITAIGEQNQDKLQRLLQAPVQ 196

  Fly   111 RRNESSFESDSSILEQMRLYYRSCKRLKPYNLKKYLQLLPPSNSTQ-------W-----PSVGRG 163
            ||...|.|      .:::.:||||     .|:|: :..|.....|:       |     |..|.|
Zfish   197 RRELESAE------RKVKEFYRSC-----INIKE-IDRLGAGPMTEVIDSCGGWDLSGAPPGGAG 249

  Fly   164 W----RPERFDWITTLGRLRLHGLNGVLLREEVLPRWDD---SRNYSIYVNK-----PSRQETQP 216
            |    .|.|.|:...|  .:..|:....:...:....||   ||| :|.:::     |.|  |..
Zfish   250 WDSGSAPIRPDFNEML--YKTQGVYSTSVFFSLTVSVDDKNSSRN-AIRIDQEGLTLPER--TLY 309

  Fly   217 MGEG-----------AMIELLLD-IGQTKRTANALARQVDDFERKLHRLQELEDDEGPREMQLGY 269
            :|:.           |::|.||. :|  ...|...:|::.|.|.||..:...|.::..:::...|
Zfish   310 LGQDEDSVKILASYKALMERLLSMLG--AHNATLKSREILDLETKLANITVSEYEDQRKDISSMY 372

  Fly   270 -------LDSYLPQLRWLSFMRQVRIDSELDLRSTLIIENIPYLRALSDLMESESPDTVCSYIML 327
                   |....|...|...:.:: .:........:::....|::.:||::::.|...:.:|::.
Zfish   373 NRITLKQLQKMAPSFHWKRLLDRI-FNDNFSEEEEIVVLATDYMQTVSDIIKTTSKRVLHNYMLW 436

  Fly   328 KWLAFLKQ--------------------QGPADISRGECVAALRRAMPLASSWLVGQQFSDPESE 372
            :.:|.|.:                    :...|:.| .|:....:...:|...|..||.....|.
Zfish   437 RMVAALSEHLSTAFRSTIHEFSREIDGTEQQLDLER-LCLTQANKHFGMALGALFVQQHFSSSSR 500

  Fly   373 SYVSSLFQRLKVRFGQILAENRMRLSPPLVHILQQKLRAVRLQMGFFQTEEIEDVEQ---YHVRI 434
            :.|..|.:.:|                   |.|.     ||||...:..||.:|..:   .|:.:
Zfish   501 AKVQELVEDIK-------------------HSLD-----VRLQELDWMDEETKDAARGKLQHMMV 541

  Fly   435 DLSGHSFYGNQLVLLRQRV-------EANHDLLYINVTNFANSTGSNLSY---LS---------- 479
             ::|:..:     ||:..:       :.|....:.|:.|       ::.|   ||
Zfish   542 -MTGYPDF-----LLKPELIDEEYAFDVNEKTYFKNILN-------SIKYNIKLSIKKIHKEVDK 593

  Fly   480 ESW----EASNSSPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGM 540
            .:|    :|.|:  .|:..:|.::.|.|:||..::.........:..:|.::.|||.||:|..|.
Zfish   594 TTWLLPPQALNA--YYLPNKNQMVFPAGILQPTLYDPEFPQSLNYGGIGAIIGHELTHGYDDWGG 656

  Fly   541 DYDAMGNI-MGPVEEIGASRQFRQGLQCL---------QQQMATGSKWIDEKLADFVALRLAYET 595
            .||..||: ....||  :.|:|::..:|:         ..|...|...:.|.:||...|:|:|..
Zfish   657 QYDRYGNLKQWWTEE--SYRKFQKKTECIVKLYDNFTVYNQRVNGRLTLGENIADLGGLKLSYHA 719

  Fly   596 FFGVRDKREPRDPLLP--QFSQRQLFFITFAQFFCGRTPVLSPRSQSEAHL-----KHAADELRV 653
            :.....:..|..| ||  :.:..|||||.|||.:|     :..|||| .:|     |||.:..||
Zfish   720 YQKWVREHGPERP-LPGLKHTHEQLFFIAFAQNWC-----MKRRSQS-IYLQLLTDKHAPEHYRV 777

  Fly   654 MQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
            :.:::.||||.|.|.|.:.:.|....:|.:|
Zfish   778 IGSVSQFEEFGRVFHCPRGSPMNPVNKCSVW 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	168/755 (22%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	166/747 (22%)
LOC100332538	XP_021322193.1	M13	146..806	CDD:189000	166/747 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920