Protein Alignment Nepl5 and mmel1

DIOPT Version :10

• Sequence 1: NP_609022.1
• Gene: Nepl5 / 33892
• FlyBaseID: FBgn0031808
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: XP_012821551.1
• Gene: mmel1 / 100145721
• XenbaseID: XB-GENE-991673
• Length: 765
• Species: Xenopus tropicalis
• Alignment Length: 779
• Identity: 176/779 - (22%)
• Similarity: 319/779 - (40%)
• Gaps: 163/779 - (20%)

  Fly     1 MLKLSLVAWLIFSLAWR---TTPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNW 62
            ::..::||.|:...:.:   .|.|.| .|.|.:.:|.         ||....||.:|||||||.|
 Frog    55 LMTCAVVALLVLYTSHKESICTTTGC-VTAAARIIQN---------MDPTIEPCTDFYQYACGGW 109

  Fly    63 QIQQQEQHSLRDRDWTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILEQM 127
                ..:|.:.:..     .||.           |...:..::|::|:...|...:.|....::.
 Frog   110 ----LNKHVIPETS-----SRYS-----------IFDILRDEMEIILKGLLEMPDQEDRDAFKKA 154

  Fly   128 RLYYRSCKRLKPYNLKKYLQLLPPSNST-QWPSVGRGWR-PERFDWI--TTLGRLRLHGLNGVLL 188
            ::.|:||........:..|.||....:. :||.....|. .:..:|.  ..|..|.......||:
 Frog   155 KILYKSCMNESLIEQRDSLPLLELLTTVGEWPVASTDWNGTKESNWSLEEKLSLLNYKFNKRVLV 219

  Fly   189 REEVLPRWDDSRNYS---IYVNKPS-----------RQETQPMGEGAMIELLLDIGQTKRTANAL 239
            ...|   |:|.|..|   ||:::||           :...|.:.| |.::.::.|.:..|....|
 Frog   220 DIFV---WNDDRESSKHIIYIDQPSLGMPSRDYYFNKGNYQRIRE-AYLQFMITIARMVREDRNL 280

  Fly   240 ARQVDDFERKLHRLQELEDD--------EGPREMQLGY-------------LDSYLPQLRWLSFM 283
            .|.....:.::.|:.:||.|        |...::.|.|             ||.:    .|.||:
 Frog   281 TRDDSLVQEEMTRVMDLETDIARATAPSEERNDVTLLYNKMTLLEFQQKFALDDF----NWTSFI 341

  Fly   284 RQV--RIDSELDLRSTLIIENIPYLRALSDLMESESPDTVCSYIMLKWLAFLKQQGPADISR--- 343
            :.|  .::.:|.....:::...|||..|.:::.:.|..|:.:|::  |...:.:  .:.:||
 Frog   342 QGVMSSVNIQLQAEEEVVVYGAPYLHQLKNILSNYSASTLQNYVV--WRMVIDR--VSSLSRRYK 402

  Fly   344 --------------------GECVAALRRAMPLASSWLVGQQFSDPESESYVSSLFQRLKVRFGQ 388
                                .|||:.:...|..|...:..::....||:..:|.|..:::..|.:
 Frog   403 DARASYRKALYGTTLEEARWRECVSYVNSNMENAVGAMYVKETFAGESKRMISDLINKVREAFIE 467

  Fly   389 ILAENRMRLSPPLVHILQQKLRAVRLQMGF--FQTEEIED-VEQYHVRIDLSGHSFYGNQLVLLR 450
            .|.|.:. :........::|..:::.|:|:  :..|:..| ::|....::.|.:.::.|.|.:|.
 Frog   468 TLDELQW-MDETSKDKAREKALSIKEQIGYPDYILEDQNDKLDQETAALNFSEYQYFENILEILN 531

  Fly   451 QRVEANHDLLYINVTNFANSTGSNLSYLSE-----SW--EASNSSPLYVRPRNLVLVPHGLLQLP 508
            ...:                  .:|..|.|     :|  .|:.:...|...||.::.|.|:||.|
 Frog   532 SGAQ------------------KSLKKLREPVDQDAWIIGAAVADAFYSPNRNQIVFPAGILQPP 578

  Fly   509 IWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQQM- 572
            .::::.........:|.|:.||:.||||..|.::|..||:........| ..|:...:|:..|.
 Frog   579 FFNKHQPQALNFGGIGMVIGHEITHGFDDNGRNFDKDGNMFDWWSNFSA-MHFKDQSRCMVYQYG 642

  Fly   573 -----------ATGSKWIDEKLADFVALRLAYETFFGVRDKREPRDPLLP--QFSQRQLFFITFA 624
                       .:|...:.|.:||...:|.||:.:....: |..::|.||  ..:.:||||:.||
 Frog   643 NYTWELAGGQNVSGIITLGENIADNGGVRQAYKAYLKWVE-RHGKEPKLPGLDLTYKQLFFLNFA 706

  Fly   625 QFFCGRTPVLSPRSQSEAH-LK---HAADELRVMQTLANFEEFSREFGCDKKAKMQASQRCRIW 684
            |.:||     |.|.:...| :|   |:..:.|||.:|.|||.|:.||.|.|..||...::||:|
 Frog   707 QVWCG-----SYRPEYARHSIKTDVHSPFKYRVMGSLQNFEAFAEEFNCKKGTKMHPVEKCRVW 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl5	NP_609022.1	M13	48..682	CDD:341056	162/725 (22%)
mmel1	XP_012821551.1	M13	95..763	CDD:341056	162/725 (22%)