DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl4 and Ece1

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_006239337.1	Gene:	Ece1 / 94204	RGDID:	620293	Length:	769	Species:	Rattus norvegicus

Alignment Length:	792	Identity:	160/792 - (20%)
Similarity:	284/792 - (35%)	Gaps:	219/792 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QNLWTA-------------LLLLGSATCGSSVPVKANDPEQSCPYLGECNSTINQQHIDTLMSYV 54
            |..|.|             ||..|...|.:::.::.............|.|..:     ::::.:
  Rat    55 QRCWAARTSVEKRLVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTS-----SILNSM 114

  Fly    55 DSEKNPCEDFYAYACGKW-RAK-----HGSHTTATMISESQINRQYEDLFLQLLRNPSAPEYGYP 113
            |...:||:||::||||.| :|.     |....|.:.:.|..     :.:...||.|.:|......
  Rat   115 DPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHN-----QAIIKHLLENSTASASEAE 174

  Fly   114 MFAKVLAHYQSCIALEKPDLRRYIELLDRDLLASLNSTHWMHLLAALGRYGYHG----------- 167
            ..|:|  :|::|              ::...:..|.:...|.|:..||.:...|
  Rat   175 KKAQV--YYRAC--------------MNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTL 223

  Fly   168 -----HY-------VQVEVRWYNATHHMIFL------LP-HNRHLNLSLTQDIYDAL-------- 205
                 ||       |.|.....|:..::|.:      || .:.:||.:..:.:....
  Rat   224 QVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLG 288

  Fly   206 -----SQDGSSWPPLHQLQEQFRSLEQNLVRLAKPHSADDTFRNYSLDQIRTEVPGLHWDEALRT 265
                 ..:.|..|.:.|:.:...:|....:...|....:..:...:..:::|..|.::|...|
  Rat   289 KLLGGGDEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFL-- 351

  Fly   266 QLGRSVPGNHVFQVDDLDAIEGLV----EYLNTVDTL-------LLNRY---SLARFLSHLLE-- 314
                    |.:|...:::..|.:|    |||..|.||       |||.|   :|.|..|..|:
  Rat   352 --------NAIFYPVEINESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQR 408

  Fly   315 -------------------LPHNPLATWESGQRSRGRNCIRHMRRSVYLPMNYVYERSFYSR--R 358
                               ||             |.:.|:.....::...:..::.::.::.  :
  Rat   409 FQDADEKFMEVMYGTKKTCLP-------------RWKFCVSDTENNLGFALGPMFVKATFAEDSK 460

  Fly   359 RHADELV--IHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPPNVTEQFYWD 421
            ..|.|::  |...|::..|.|:.        :.:|..:|.:.|...:...:|.  ||    |..|
  Rat   461 NIASEIILEIKKAFEESLSTLKW--------MDEDTRRSAKEKADAIYNMIGY--PN----FIMD 511

  Fly   422 SDRRWSVGRD-------FYENHLNSLLYYYTLVAD-LESSSDQEERDIWYSFNMHTPEFPDNIDA 478
            ......|..|       ::||.:....:.:.:.|| |..:.:   ||.|    ..||..     .
  Rat   512 PKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPN---RDQW----SMTPPM-----V 564

  Fly   479 TPYFYCLGNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNLRNFS 543
            ..|:....|.|..|...::.||:..:...||.:|.:...:|||:.||||....:||..||||.:.
  Rat   565 NAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWW 629

  Fly   544 DQLGEVELYNGAVGCL----NSSAV---------MLNERTSDVSGSRLAMQTYGGDWLTRSG--- 592
            .. ..||.:.....|:    |:.:|         .|.|..:|..|.:.|.:.| .:|:.::|
  Rat   630 KN-SSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAY-QNWVKKNGAEQ 692

  Fly   593 --------NGRLYFLQFAHFFC-------GDEG--DQYHDSGSQRLNYALGQVPQFAEVFRCHVG 640
                    :.:|:||.||..:|       ..||  ...|.....|:..:|....:|:|.|||.:|
  Rat   693 ILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLG 757

  Fly   641 SGMTSADQCPFW 652
            |.|....:|..|
  Rat   758 SPMNPRHKCEVW 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	148/720 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	148/718 (21%)
Ece1	XP_006239337.1	PepO	105..769	CDD:226118	151/740 (20%)
Ece1	XP_006239337.1	M13	118..767	CDD:189000	148/720 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920