DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and ece2b

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_017206531.1	Gene:	ece2b / 793465	ZFINID:	ZDB-GENE-131120-140	Length:	794	Species:	Danio rerio

Alignment Length:	768	Identity:	169/768 - (22%)
Similarity:	298/768 - (38%)	Gaps:	162/768 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LWTALLLLGSATCGSSVPVKAN-DPEQS-CPYLGECNSTINQQHIDTLMSYVDSEKNPCEDFYAY 67
            |.:.|.|.|   |..::.|:.| ||.:| |  |.|...|:..:.::.|    |...:||:|||.|
Zfish    69 LASLLALFG---CAVTLGVRYNRDPARSIC--LTEACVTVASKIVEAL----DRSADPCQDFYQY 124

  Fly    68 ACGKWRAKH----GSHTTATMISESQINRQYEDLFLQLLRN-----PSAPEYGYPMFAKVLAHYQ 123
            |||.|..|:    |....:|.   :.|..|.:.:...||.|     .|..|      .|..::|.
Zfish   125 ACGGWVRKNPLPDGRSRWSTF---NSIWDQNQAVLKHLLENGTFNSSSEAE------RKTQSYYL 180

  Fly   124 SCI---ALEKPDLRRYIELLDR----DLLASLNSTHWMHLLAAL-GRYGYHGHY-VQVEVRWYNA 179
            ||:   .:|:...:..::|:.:    ::..|.:..:::.:|..: |.|.....: |.|.|...|:
Zfish   181 SCLNEQRIEELGAQPLMDLITKIGGWNITESWDKENFLDVLKIISGPYRAQPFFTVSVSVDPKNS 245

  Fly   180 THHMI-------FLLPHNRHLN----------LSLTQDIYDALSQDGSSWPPLHQLQEQFRSLEQ 227
            ..::|       ||...:.:||          |....::...|..|.:|  ...|:| |....|.
Zfish   246 NSNVIQVDQSGLFLPSRDYYLNKTNEKVLKAYLDYMVELGLLLGGDKNS--TRGQMQ-QILDFET 307

  Fly   228 NLVRLAKP----HSADDTFRNYSLDQIRTEVPGLHWDEALRTQLGRSVPGNHVFQVDDLDAI--- 285
            .|..:..|    ...:..:...::..::...|.:.|.:.|.:.|.       ..:::|.:.:
Zfish   308 ALANITVPQDERRDEEKIYHKITIADLQVLAPAIEWLDYLNSVLS-------PLELNDTEPVVVY 365

  Fly   286 -----EGLVEYLNTVDTLLLNRYSL-------ARFLSHLLELPHNPLATWESGQRS----RGRNC 334
                 :.:.|.:|..|..|||.|.:       |..|....|...:.|.....|.:.    |.:.|
Zfish   366 AKEYMQQVSELINKTDHSLLNNYMIWNLVQKGASSLDQRFENAQDKLLESLYGTKKSCTPRWQTC 430

  Fly   335 IRHMRRSVYLPMNYVYERSFYSRRRHADEL---------------VIHSVFQQLQSQLELRVQ-- 382
            |.:...::...:..::.::.:.::....:|               .:|::...:.:|.|..:.
Zfish   431 IGNTDDTLGFALGALFVKATFDKQSKEIDLNGGAFLPSCGRNVNSTVHNLMFSVITQAEGMINEI 495

  Fly   383 HNAFNLSQDLVKSLQAKVHQMRINVGNLPPNVT--EQFYWDSDRRWSVGRDFYE----NHLNSLL 441
            ..||..:.|.:|.:..:..|...:..:...::.  ..|..||.....| .|.||    |...:::
Zfish   496 RTAFKGALDDLKWMDEQTRQAAKDKADAIYDMIGFPDFILDSKELDDV-YDGYEVTEDNFFQNMI 559

  Fly   442 YYYTLVADLESSSDQ----EERDIWYSFNMHTPEFPDNIDATPYFYCLGNIIFVPYSYVKRPFFD 502
            .:|...|.:  .:||    ..||.|       ...|..::|  |:....|.|..|...::.||:.
Zfish   560 NFYNFSARV--MADQLRKPPNRDQW-------SMTPPTVNA--YYMPTKNGIVFPAGILQAPFYA 613

  Fly   503 ANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNLRNFSDQLGEVELYNGAVGC--------- 558
            .:...||.:|.:...:|||:.||||....:||..||||::. |...||.:.....|
Zfish   614 QDHPKALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRSWW-QNSSVEAFKNRTECMVDQYTQYT 677

  Fly   559 LNSSAV----MLNERTSDVSGSRLAMQTYGGDWLTRSG-----------NGRLYFLQFAHFFC-- 606
            :|...:    .|.|..:|..|.:.|...| ..|:.::|           |.:|:|:.||..:|
Zfish   678 INGEHINGKQTLGENIADNGGLKAAYHAY-RSWVQKNGEEKRLPAVNLTNDQLFFVGFAQVWCSV 741

  Fly   607 -----GDEG--DQYHDSGSQRLNYALGQVPQFAEVFRCHVGSGMTSADQCPFW 652
                 ..||  ...|.....|:...|...|:|||.|:|.:||.|.|..:|..|
Zfish   742 RTPESAHEGLMTDPHSPPKYRVIGTLSNSPEFAEHFQCPLGSSMNSGHRCEVW 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	150/709 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	151/707 (21%)
ece2b	XP_017206531.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020