DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and Ecel1

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_068544.2	Gene:	Ecel1 / 60417	RGDID:	61806	Length:	775	Species:	Rattus norvegicus

Alignment Length:	782	Identity:	168/782 - (21%)
Similarity:	279/782 - (35%)	Gaps:	221/782 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ALLLL-----GSATCGSSVPVKANDPEQSCPYLGECNSTINQQHIDTLMSYVDSEKNPCEDFYAY 67
            |:|.|     |:|..|.:.|       :.||   |..:.......  |.:.:|:..:||:|||::
  Rat    78 AMLALKYLGPGAAGTGGACP-------EGCP---ERKAFARAARF--LSANLDASIDPCQDFYSF 130

  Fly    68 ACGKWRAKHG------SHTTATMISESQINRQYEDLFLQLLRNPSAPEYGYPMFAKVLAHYQSCI 126
            |||.|..:|.      ::.|...|.|     |.|:...:||..|:....|... .||.|.::||:
  Rat   131 ACGGWLRRHAIPDDKLTYGTIAAIGE-----QNEERLRRLLARPTGGPGGAAQ-RKVRAFFRSCL 189

  Fly   127 ALEKPDLRRYIELLDRDLLASLNSTHWMHLLAALGRYGYHGHYVQVEVRW------------YNA 179
                 |:|....|..|.:|..:.......|..|..|.|        ..||            |:|
  Rat   190 -----DMREIERLGPRPMLEVIEDCGGWDLGGAADRPG--------AARWDLNRLLYKAQGVYSA 241

  Fly   180 THHMIFLLPHNRHLNLSLTQDIYD--------ALSQDGSSWP----------------------- 213
            .  .:|          |||..:.|        .:.|||.:.|
  Rat   242 A--ALF----------SLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKVLAAYKVFM 294

  Fly   214 ----------PLHQLQEQFRSLEQNLVRLAKPHSAD------DTFRNYSLDQIRTEVPGLHWDEA 262
                      .:.|..::...|||.|..::.....|      ..:...:|.|::...|.|.|...
  Rat   295 ERLLRLLGADAVEQKAQEILQLEQRLANISVSEYDDLRRDVSSVYNKVTLGQLQKITPHLQWKWL 359

  Fly   263 LRTQLGRSVPGNHVFQVDDLDAIEGLV----EYLNTVDTL-------LLNRYSLAR---FLSHLL 313
            |          :.:|| :|....|.:|    :|:..|..|       :|:.|.:.|   .||..|
  Rat   360 L----------DQIFQ-EDFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHL 413

  Fly   314 ELP-----HNPLATWESGQRSR--GRNCIRHMRRSVYLPMN--YVYERSFYSRRRHADELV--IH 367
            ..|     |......|...:.:  .|.|:....|...:.:.  :|:|....:.:....:||  |.
  Rat   414 SPPFREALHELAKEMEGNDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIK 478

  Fly   368 SVFQQLQSQLE-LRVQHNAFNLSQDLVKSLQAKVHQMRINVGN----LPPNVTEQFYWDSDRRWS 427
            .:..|...:|: :..|..|         :.:||:..|.:.||.    |.|...::.|     .:.
  Rat   479 YILGQRLEELDWMDAQTKA---------AARAKLQYMMVMVGYPDFLLKPEAVDKEY-----EFE 529

  Fly   428 V-GRDFYENHLNSLLYYYTLVADLESSSDQEERDIWYSFNMHTPEFPDNIDATPYFYCLGNIIFV 491
            | .:.:::|.|||:  .:::...::....:.::..|.     .|  |..::|  |:....|.:..
  Rat   530 VHEKTYFKNILNSI--RFSIQLSVKKIRQEVDKSTWL-----LP--PQALNA--YYLPNKNQMVF 583

  Fly   492 PYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNL------RNFSDQLGEVE 550
            |...::...:|.:|..:|.||.:...:|||:.|.:|.....||..|||      .::|..|.:.|
  Rat   584 PAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLHKAE 648

  Fly   551 ----------LYNGAVGCLNSSAVMLNERTSDVSGSRLAMQTYGGDWLTRSG-----------NG 594
                      :||..|...::    |.|..:|:.|.:||...| ..|:...|           :.
  Rat   649 CIVRLYDNFTVYNQRVNGKHT----LGENIADMGGLKLAYYAY-QKWVREHGPEHPLHRLKYTHN 708

  Fly   595 RLYFLQFAHFFCGDEGDQ------YHDSGSQRLNYALGQVPQFAE---VFRCHVGSGMTSADQCP 650
            :|:|:.||..:|.....|      ..|..:......||.|.||.|   .|.|...|.|....:|.
  Rat   709 QLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCS 773

  Fly   651 FW 652
            .|
  Rat   774 VW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	154/723 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	154/721 (21%)
Ecel1	NP_068544.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..51
Ecel1	NP_068544.2	M13	121..773	CDD:341056	154/723 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920