Protein Alignment Nepl4 and PHEX

DIOPT Version :10

• Sequence 1: NP_609019.1
• Gene: Nepl4 / 33889
• FlyBaseID: FBgn0031805
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_000435.3
• Gene: PHEX / 5251
• HGNCID: 8918
• Length: 749
• Species: Homo sapiens
• Alignment Length: 754
• Identity: 153/754 - (20%)
• Similarity: 254/754 - (33%)
• Gaps: 221/754 - (29%)

  Fly    50 LMSYVDSEKNPCEDFYAYACGKWRAKHGSHTTATMISESQINRQYEDLFLQLLRNPSAPEYG-YP 113
            ::|.|:...:||::|:.:||..|            ||.:.|.   ||:          |.|| ||
Human    66 ILSKVNLSVDPCDNFFRFACDGW------------ISNNPIP---EDM----------PSYGVYP 105

  Fly   114 MF---------------------------AKVLAHYQSCI---ALEKPDLRRYIELLDRDLLASL 148
            ..                           ||:|  |.||:   |:||.|.:..:.:|..
Human   106 WLRHNVDLKLKELLEKSISRRRDTEAIQKAKIL--YSSCMNEKAIEKADAKPLLHILRH------ 162

  Fly   149 NSTHWMHLLAALGRYG---------------YHGHYV-QVEVRWY-----NATHHMIFLLPHNRH 192
            :...|..|.:.:|..|               :.|.|. .|.:|.|     .|::..|..| ....
Human   163 SPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKL-DQAT 226

  Fly   193 LNLSLTQDIYD-------------------ALSQDGSSWPPLHQLQEQFRSLEQNLVRLAKPH-- 236
            |:|::.:|..|                   |:....:|....|.::...| ||..:..:..||
Human   227 LSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLR-LEIKIAEIMIPHEN 290

  Fly   237 -SADDTFRNYSLDQIRTEVPGLHW--------DEALRTQLGRSVPGNHVF-----QVDDLDAIEG 287
             :::..:...::.::...:|...|        |..|...|....|..:|.     ...||..|.|
Human   291 RTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILG 355

  Fly   288 LVEYLNTVDTLLLNRYSLARF-------------LSHLLELPHNPLATWESGQRSRGRNCIRHMR 339
             .|...|:...|:.|...:|.             .|.:::.....|..|:        .|:..:.
Human   356 -SERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWD--------KCVNFIE 411

  Fly   340 RSVYLPMNYVYERSFY------SRRRHADELV--IHSVFQQLQSQLELRVQHNAFNLSQDLVKSL 396
            .:  ||  ||..:.|.      .::...:|||  :...|..:..:....:.......:::..:::
Human   412 SA--LP--YVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAV 472

  Fly   397 QAKVHQMRINVGNLPPNVTEQFYWDSDR---RWSVGRDFYENHLNSLLYYYTLVADLESSSDQEE 458
            .|||        ..|..:....:.:.|.   ::|.. |::.|.|.:..|.        :.||
Human   473 LAKV--------GYPEFIMNDTHVNEDLKAIKFSEA-DYFGNVLQTRKYL--------AQSD--- 517

  Fly   459 RDIWYSFNMHTPEFPDNIDATPYFYCLG-NIIFVPYSYVKRPFFDANFWP-ALLYGDLANTLGHE 521
             ..|....:...|:..|......||... |.|..|...:::|||....:| :|.||.:...:|||
Human   518 -FFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHE 581

  Fly   522 IMHAFDTDLVDYDAQGNL---------RNFSDQ----LGEVELYNGAVGCLN-SSAVMLNERTSD 572
            ..|.||.:...||..|||         ..|.::    :.:...|......|| .....|.|..:|
Human   582 FTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIAD 646

  Fly   573 VSGSRLAMQTYGGDWLT--RSG------------NGRLYFLQFAHFFCGDEGDQ---------YH 614
            ..|.|.|.:.| ..|:.  |.|            |.:|:||.:||..|.....:         .|
Human   647 NGGLREAFRAY-RKWINDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAH 710

  Fly   615 DSGSQRLNYALGQVPQFAEVFRCHVGSGMT-SADQCPFW 652
            .....|:|.|:....:|.:.|.|...|.|. ..|.|..|
Human   711 SPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	GluZincin	59..649	CDD:472708	149/740 (20%)
PHEX	NP_000435.3	M13	74..740	CDD:341056	147/735 (20%)