DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and Nepl19

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_651644.1	Gene:	Nepl19 / 43411	FlyBaseID:	FBgn0039612	Length:	671	Species:	Drosophila melanogaster

Alignment Length:	729	Identity:	146/729 - (20%)
Similarity:	235/729 - (32%)	Gaps:	259/729 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LMSYVDSEKNPCEDFYAYACGKWRAKHGSHTTATMISESQIN-----------------RQYEDL 97
            :.||:..:.:.||:||.|:||.|               .|||                 :.|...
  Fly    65 MRSYMQQDADACENFYDYSCGNW---------------PQINPANDAYPRETNFVQLLLKAYSHK 114

  Fly    98 FLQLLRNPSAPEYGYPMFAKVLAHYQSCIALEKPDLRRYIELLDRDLLASLNSTHWMHLLAALGR 162
            ..:|:..|:..|.......::...|.||             ||.|.:...|.......::|..||
  Fly   115 QQRLMEQPANVETDEVAVLRLKEFYASC-------------LLFRQVPEDLYRRQLQEIVADFGR 166

  Fly   163 YGYHGHYVQVEVRWYNATHHMIFLLPHNRHLNLSLTQDIYDALSQDGSSWPPLHQLQEQFRSLEQ 227
                                    :|               .||..|..||     .|:|..|:
  Fly   167 ------------------------MP---------------VLSLPGQEWP-----AEEFDWLD- 186

  Fly   228 NLVRLAKPHSADDTFR-NYSLDQIRTEVPGLHWDEALRTQLGRSVPGNHV--------------- 276
            .:.|:.:.:..|.... ..|.|:|....|.....||.|..:...: .||:
  Fly   187 TVARIKRQYGFDILLLFQQSADRIYVGQPKQILPEANRKAVAEDI-ANHLERHLGVDPKVAVTTA 250

  Fly   277 ------------FQVD-------------DLDAIE--GLVEYLNTV-DTLLLNRYSLARFLSHLL 313
                        ..||             |.|.::  .|.:::.|| |..||...||.:.:...|
  Fly   251 REITEFEQKIAAIMVDRRVGVMSKLYTPSDADYVDVSKLTQFVETVLDRELLANESLYQHVPDYL 315

  Fly   314 --------ELPHNPLATWESGQRSRGRNCIRHMRRSVYLPMNYVYE---RSFYSRRRHA------ 361
                    |.|.:.||                         |||:.   :.||..|..:
  Fly   316 MKIDELVTETPPHVLA-------------------------NYVFNELLKHFYYERAESVVEQCV 355

  Fly   362 -------DELVIHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPPNVTEQFY 419
                   .||:.|.:|:|.:.:..|:   :.:.:.|.|.:|.:..:.....|.  |.|...||..
  Fly   356 SRVRDLFGELLDHMLFEQYEDEGTLK---DIYVVWQQLQRSFRGVLQNSSANW--LVPETREQLL 415

  Fly   420 WDSDRRWSVGRDFYENHLNSLLYYYTLVADLESSSDQEE-----RDIWYSFNMHT---------- 469
                           ..||:........|::..:...||     ||  |..|:.|
  Fly   416 ---------------EQLNTTSLVINGYAEVNFTQRYEELHLKPRD--YLHNLRTILNHQSLRVK 463

  Fly   470 PEFPDNIDATPYFYCLGNIIFVPYSYVKRPFFDANFWP-ALLYGDLANTLGHEIMHAFDTDLVDY 533
            .:...::...|    :|..:.:|.:.::..|..:.::| |:.||.|...|..::.|:.: |...:
  Fly   464 VKTQTSVTYDP----VGKRVLLPVALLQPNFLWSRYYPKAVRYGSLGTLLAQQLAHSLE-DASKW 523

  Fly   534 DAQG----NLRN--FSDQLGEVELYNGAVGCLNSSAVMLNERTSDVSGSRLAMQTY--------- 583
            ||:.    :.|.  |.:|.|.:.| ||..  |..|.:.. |..:|....::|...|
  Fly   524 DAKSFAEYSKRKSCFKEQYGRLRL-NGHY--LPESDLQA-ENIADNLAIQVAYHAYRRLLAELDP 584

  Fly   584 ---GGDWLTR--SGNGRLYFLQFAHFFCGDEGDQYHDSGS--------QRLNYALGQVPQFAEVF 635
               |.:.|.:  .|:.||:||.||..:|.|..:|:.|..|        .|:..||.....|...|
  Fly   585 SFLGSESLPQLNLGSRRLFFLSFAQLWCNDANEQFRDKQSLFLGTPNALRVLGALSNFRAFGRDF 649

  Fly   636 RCHVGSGMTSADQC 649
            .|...|.|||..:|
  Fly   650 NCGTASRMTSPQKC 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	142/720 (20%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	143/718 (20%)
Nepl19	NP_651644.1	PepO	67..657	CDD:226118	142/719 (20%)
Nepl19	NP_651644.1	M13	73..664	CDD:189000	144/721 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920