DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and Nepl18

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	766	Identity:	162/766 - (21%)
Similarity:	280/766 - (36%)	Gaps:	208/766 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LWTALLLLGSATCGSSVPVKANDPEQSCPYLGECNS-----TINQQHIDTLMSYVDSEKNPCEDF 64
            ||..||:       :.||..|...:...|:..:..|     .|.|..:..:.:.:..|.:||:||
  Fly     7 LWLCLLV-------AIVPAMAKPSDAGDPFADDLTSDYAKKIIVQAKVAEMKTMMKPEVSPCDDF 64

  Fly    65 YAYACGKWRAKHGSHTTATMISE------SQINRQYEDLFLQLLRNPSAPEYGYPMFAKVLAHYQ 123
            |.:|||.|.    .|..|.::.:      ..|::.::....:|||   |.:....:..|:...|.
  Fly    65 YTHACGNWH----RHNPAQLLGDVMTDNFKLISKGFDRRLQRLLR---ANDLQSELEKKMQRFYM 122

  Fly   124 SCIALEKPDLRRYIELLDRDLLASLNSTHWMHLLAALGRYGYHGHYVQVEVRWYNATHHMIFLLP 188
            ||..:.:.|:..        .||..|.......|.||           |..:|.
  Fly   123 SCNLVHRDDVHY--------KLALENVIREYGTLPAL-----------VGAQWN----------- 157

  Fly   189 HNRHLNLSLTQDIYDALSQDGSSWPPLHQLQEQF--------------RSLEQNLVRLAKP-HSA 238
                             |.|.|.|..:.|:|.::              |:...|.|.:::| ...
  Fly   158 -----------------SSDFSWWRTVAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQPDFKT 205

  Fly   239 DDTFRNYSLDQIRTEVP-----GL------HWDEALRTQLGRSVPGN-----------HVFQVDD 281
            .:|.....::::||.:.     ||      |..|.| |:|.|:....           .::.|.|
  Fly   206 INTRLTNLMEEVRTSMDLQQYFGLSSSVAKHTAEQL-TELERTFSSGGSGAATLQESLSLYTVAD 269

  Fly   282 LDAIEGLVEYLNTVD--TLLLNRYSLARFL---------SHLLELPHNPLAT------WESGQ-- 327
            |.  |...::||..:  .|:|...::.:.|         ..||.:...||||      |:..:
  Fly   270 LQ--EKYSDHLNFTEFLGLILGEENIPKSLYIYDEEYLDKALLTMRSTPLATQANYVLWKLLEDF 332

  Fly   328 --RSRGRNCIRHMRRSVYLPMNYVYERSFYSRRRHAD-ELVIHSVFQQLQSQLELRVQHNAFNLS 389
              .::.::.::....|.......:.|.:.|.|.|:.| |..:|.::.|::.....|:..:..:..
  Fly   333 LVDAQPKDMVKWCTESTKKYFGKLAEHAVYKRYRNPDVESEVHKIWDQIKGIFRQRLLGDKLDWI 397

  Fly   390 QDLVKSLQ-AKVHQMRINVGNLPPNVTEQFYWDSDRRWSVGRDFYENHLNSLLYYYTLVADLESS 453
            .:..::|. .|:.:|.:|:.:          :|.:...:|..:.:.:.||    |.:.|..|..:
  Fly   398 SNATRTLAIEKLERMHLNINS----------YDEENFENVYGEVFIDRLN----YVSNVQQLLIA 448

  Fly   454 SDQEERDIWYSFNMHTPEFPDNIDA------TPYFYCLGNIIFVPYSYVKRPFFDANFWP-ALLY 511
                 :.|.:...::.|  .|::||      ||.:....|.|.:|.:.::..:|..:.:| ||.|
  Fly   449 -----KGIRFVARINQP--ADSVDATELLGFTPAYNIQENNITIPVALLQPRYFWGDQYPEALKY 506

  Fly   512 GDLANTLGHEIMHAFDTDLVDYDAQGNLRNFSDQLGEVEL---------------YNGAVGCLNS 561
            ..|...|.||::|.||.|...|||.|||..:.|.....|.               |.|:.  |..
  Fly   507 ATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQYHEYQYGGSK--LPE 569

  Fly   562 SAVMLNERTSDVSGSRLAMQTYGGDWL-----------TRSG---NGR-LYFLQFAHFFCGD--- 608
            |... :|..:|..|.:||...| ..||           |..|   |.| |:||.:|...|.|
  Fly   570 SKDQ-SENIADSGGLKLAYAAY-ELWLGQQSEEVLQRETMEGLPFNSRQLFFLGYAQLLCDDVQF 632

  Fly   609 -------EGDQYHDSGSQRLNYALGQVPQFAEVFRCHVGSGMTSADQCPFW 652
                   :.|: |.....|:...|....:|..||.|...:.|....:|..:
  Fly   633 LFQPWVSQSDR-HAPSKYRVIGPLSNFQEFPWVFNCSQSAPMDPEYKCAIY 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	149/704 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	149/702 (21%)
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	151/710 (21%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	149/703 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920