DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and Nep5

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster

Alignment Length:	804	Identity:	168/804 - (20%)
Similarity:	274/804 - (34%)	Gaps:	262/804 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 TLMSYVDSEKNPCEDFYAYACGKWRAKH---GSHTTATMISESQ--INRQYEDLFLQLLRNPSAP 108
            :|:..:|.:.:||||||.:.||:|..:|   .|.|:.....|.|  |.|...: ||:.....|.|
  Fly   141 SLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVRE-FLRSNITKSEP 204

  Fly   109 EYGYPMFAKVLAHYQSCI---ALEKPDLRRYIELLDR----DLLASLNSTHWMHLLAALGRYGYH 166
            |    ...|....|::|:   .|:|.||...|..|.|    .|.::||.|     |.:..:|...
  Fly   205 E----AVGKAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSALNLT-----LGSGSKYATE 260

  Fly   167 GHYVQVEVRWYNA----THHM---------IFLLPHNRHLN-LSLTQDIYDA---LSQDGSSWPP 214
            .  ..|:..|..:    ..|:         :|..|.||.:| ::|.....|:   .:.|.|
  Fly   261 A--ANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSAFPFNNDDS---- 319

  Fly   215 LHQLQEQFRSLEQNLVRLAKPHSADD-----------------TFRNYSLDQIRTEV-------- 254
             |::   .|.:.:..:.:......||                 |.....|..:|..:
  Fly   320 -HKM---LRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVD 380

  Fly   255 PGLHWDEA----------------------------------------------LRTQLGRSV-- 271
            |.::.:||                                              |:.|..:::
  Fly   381 PNVNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPADDIVYITLQDLQNQTDKNIAP 445

  Fly   272 -------------------PGN--------HVFQVDDLDAIEGLVEY--------------LNTV 295
                               .||        .:....|:..::.:|||              |:|:
  Fly   446 KTLPIWVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTI 510

  Fly   296 DTLLLNRYSLARFLSHLLELPHNPLATWESGQRSRGRNCIRHMRRSVYLPMNYV----------- 349
            :.|:|:..|..|    ||...:..:|....|...|...|...:...:.:.::||
  Fly   511 EELVLHTSSSMR----LLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVSYVLADADFTKEKL 571

  Fly   350 --YERSFYSRRRHADELVIHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPP 412
              .||.....||..|.||..:.:....::.                |::| |..:|:..:| .||
  Fly   572 PKVERMLSDIRRSFDRLVKSTSWMDAATKR----------------KTIQ-KSAEMKSFIG-FPP 618

  Fly   413 NVTEQFYWDSDRRWSVGRDFYE-------NHLNSLL-YYYTLVADLESSSDQEERDIWYSFNMHT 469
                   |  .|..||...:||       .||.:|: :.:..:.|..:..|:.|...|.:
  Fly   619 -------W--LRNASVLNAYYEGAEVNASTHLENLMDFVHWQMMDKLNEMDKPEPIGWAT----- 669

  Fly   470 PEFPDNIDATPYFYCLGNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYD 534
              .|.|::|...|.  .|.|.||.:.::.||:|... .||.||.:...||||:.|.||.....:|
  Fly   670 --SPSNVNAFHTFQ--SNAITVPIAILQYPFYDLGL-EALNYGSIGTILGHELTHGFDDSGRRFD 729

  Fly   535 AQGNL------RNFSDQLGE----VELYN----GAVGCLNSSAVMLNERTSDVSGSRLAMQTY-- 583
            ..||:      |...:.:..    ||.|:    ..:.......:.|.|..:|..|.|.|...|
  Fly   730 RAGNMVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRL 794

  Fly   584 -----GGD-----WLTRSGNGRLYFLQFAHFFC---GDEGDQY-----HDSGSQRLNYALGQVPQ 630
                 |.:     .|....:.:|:|:.|.:.:|   .....:|     |..|..||...|....:
  Fly   795 YVKEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRYALTDSHCPGQMRLRGVLSNSEE 859

  Fly   631 FAEVFRCHVGSGMTSADQ--CPFW 652
            ||..|:|..|:.| :.||  |..|
  Fly   860 FARTFKCARGTPM-NPDQPKCRIW 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	162/789 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	164/789 (21%)
Nep5	NP_733186.2	PepO	146..882	CDD:226118	166/797 (21%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	164/790 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920