DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and MME

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_000893.2	Gene:	MME / 4311	HGNCID:	7154	Length:	750	Species:	Homo sapiens

Alignment Length:	765	Identity:	162/765 - (21%)
Similarity:	286/765 - (37%)	Gaps:	217/765 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GECNSTINQQHIDTLMSYVDSEKNPCEDFYAYACGKWRAKHGSHTTATMISESQINR-QYEDLFL 99
            |.|.|:...:....|:..:|:...||.||:.||||.|..::....|::......|.| :.|.:..
Human    55 GICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLK 119

  Fly   100 QLLRNPSAPEYGYPMFAKVLAHYQSCI---ALEK----------PDL-----------RRY-IEL 139
            .:|:.|...:......||.|  |:|||   |::.          ||:           ::| ...
Human   120 DVLQEPKTEDIVAVQKAKAL--YRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASW 182

  Fly   140 LDRDLLASLNSTHWMHLLAALGRYGYHGHYVQVEVRWYNATHHMIFLLPHNRHLNLSL-TQDIYD 203
            .....:|.|||.:...:|..|        :|..:.:  |:.:|:|    |.....|.| ::|.|:
Human   183 TAEKAIAQLNSKYGKKVLINL--------FVGTDDK--NSVNHVI----HIDQPRLGLPSRDYYE 233

  Fly   204 A--------------------LSQDGSSWPPLHQLQEQFRSLEQNLV---------RLAKPHSAD 239
            .                    |.:.....|    :.|...:||.|.|         ..|||...:
Human   234 CTGIYKEACTAYVDFMISVARLIRQEERLP----IDENQLALEMNKVMELEKEIANATAKPEDRN 294

  Fly   240 D---TFRNYSLDQIRT----EVPG-----LHWDEALRTQLGRSVPGNHVFQVDDLDAIEGLVEYL 292
            |   .:...:|.||:.    |:.|     |::...:.:.:..|:       .::.|.:....|||
Human   295 DPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISI-------TNEEDVVVYAPEYL 352

  Fly   293 NTVDTLLLNRYSLARFLSHL------LELPHNPLATWE-------------SGQRSRGRNCIRHM 338
            ..:.. :|.:|| ||.|.:|      ::|..:...|::             :.:.:..|.|..::
Human   353 TKLKP-ILTKYS-ARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYV 415

  Fly   339 RRSVYLPMNYVY-ERSFYSRRRH-ADELV--IHSVFQQ-------LQSQLELRVQHNAFNLSQ-- 390
            ..::...:..:| |.:|....:| .::|:  |..||.|       :.::.:.|.:..|..:.:
Human   416 NGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI 480

  Fly   391 ----DLVKSLQAKVHQMRINVGNLPPNVTEQFYWDSDRRWSVGRDFYENHLNSLLYYYTLVADLE 451
                |:|.      :..::|...|..|..|.             :::||.:.:|.:..:  ..|:
Human   481 GYPDDIVS------NDNKLNNEYLELNYKED-------------EYFENIIQNLKFSQS--KQLK 524

  Fly   452 SSSDQEERDIWYSFNMHTPEFPDNIDATPYFYCLG-NIIFVPYSYVKRPFFDANFWPALLYGDLA 515
            ...::.::|.|.|          .......||..| |.|..|...::.|||.|....:|.||.:.
Human   525 KLREKVDKDEWIS----------GAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIG 579

  Fly   516 NTLGHEIMHAFDT---------DLVDYDAQGNLRNFSDQ--------------LGEVELYNGAVG 557
            ..:||||.|.||.         ||||:..|.:..||.:|              |...:..||
Human   580 MVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNG--- 641

  Fly   558 CLNSSAVMLNERTSDVSGSRLAMQTYGGDWLTRSG-----------NGRLYFLQFAHFFCGDEGD 611
             :|:    |.|..:|..|...|.:.| .:::.::|           :.:|:||.||..:||....
Human   642 -INT----LGENIADNGGLGQAYRAY-QNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRP 700

  Fly   612 QY---------HDSGSQRLNYALGQVPQFAEVFRCHVGSGMTSADQCPFW 652
            :|         |..|:.|:...|....:|:|.|.|...|.|....:|..|
Human   701 EYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	155/739 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	155/737 (21%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:189000	155/737 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920