DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and Nepl13

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster

Alignment Length:	768	Identity:	165/768 - (21%)
Similarity:	280/768 - (36%)	Gaps:	241/768 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 INQQHIDTLMSYVDSEKNPCEDFYAYACGKWRAKHGSH------TTATMISESQINRQYEDLFLQ 100
            :.|:....:..|::...:||.||:.||||:|...|...      :||..:.|::|:.|.:    |
  Fly    52 VRQKIATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQ----Q 112

  Fly   101 LLRNPSAPEY---GY-----PMFAKVLAHYQSCIALE--KPDLRRYIE--LLDRDLLASLNSTHW 153
            ||..|..|::   ||     ....||.|.|:||:|:|  ..:.||::.  |.|...|.::.:::|
  Fly   113 LLTQPLPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPNSNW 177

  Fly   154 MH------LLAALGR-YGYH---GHYVQVEVRWYNATHHMIF-------LLPHNRHLNLSLTQ-- 199
            .|      .|..|.| ||..   |  :::::.......:.|:       ::| ..|.|...|:
  Fly   178 QHNRQWVQTLGELRRNYGLDILLG--LEIDLNLQTMKGNTIYFGEPKLTIIP-AEHCNALATRGA 239

  Fly   200 ----DIYDALSQDGSSWPPLHQLQEQFRS-----------LEQNLVR-------------LAKPH 236
                ::|:.:.|         |:.|..|.           ...:::|             :.||
  Fly   240 QVRDEVYELVQQ---------QVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDIQKP- 294

  Fly   237 SADDTFRNYSLDQIRTEVPGLH---WDEALRTQLG-------RSVPGNHVFQVDDLDAIEGLVE- 290
              ::.|.    ..|:.::.|..   ..|.||.|.|       .|..|||   :|....:|.::|
  Fly   295 --EEEFP----PAIQAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNH---LDFKMLVEVILES 350

  Fly   291 ------YL-------NTVDTLLL-NRYSLARFLSH--LLELPHNPLATWESGQRSRGRNCIRHMR 339
                  ||       :.|.|:.. ||.::..::.:  |.||...|    |.....|.|.|::
  Fly   351 QYPSQVYLRSPEYVKHVVRTVKANNRITVGGYILYVALNELNQPP----EEAPSQRARQCVQ--- 408

  Fly   340 RSVYLPMNYVYERSFYSRRRHADELVIHSVFQQ-LQSQLELRVQHNAFNLSQDLVKSLQAKVHQM 403
                     |.:|.|        ..|:..:||: :|..   ..:|:...:..|::|:|:
  Fly   409 ---------VTQRLF--------PQVLGEMFQRHVQRD---NAKHDLDAVFNDVIKALE------ 447

  Fly   404 RINVGNLPPNVTEQFY--W--DSDRRWSVGRDFYENHLNSLLYYYTLVADLESSSDQEERDIW-- 462
                        |||:  |  ::|||  ..|.....:..||..|.:|  ||.....|:..|.|
  Fly   448 ------------EQFHVEWMDENDRR--AARTRLSQYRVSLPDYQSL--DLTDLQFQKSEDYWRR 496

  Fly   463 ----YSFNMHTP----------EFPDNIDATPYFYCLG---NIIFVPYSYVKRPFFDANFWPALL 510
                ..:..|..          :..|.:||......|.   .::.|.:..::.|:::..:..:|.
  Fly   497 LEIALKYRSHQQFEALRGNDFGQDADGLDAFEVRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLK 561

  Fly   511 YGDLANTLGHEIMHAFDTDLVDYDAQGNLRNFSDQLGEVEL--YNGAVGCLNS------------ 561
            |..|.:.|...::.|||.     :...|....:.|..||.:  |..|..|..:
  Fly   562 YALLGHRLASALVQAFDD-----EGWNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPGE 621

  Fly   562 --SAVMLNERTSDVSGSRLAMQTYGGDWLTRSG------------------NGRLYFLQFAHFFC 606
              :|..|.|..:|.||..||...|.. ||.:..                  |.:|:|:.||...|
  Fly   622 FRNATRLREIIADGSGLNLAFNAYLA-WLEQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRC 685

  Fly   607 GDEGDQ----------YHDSGSQRLNYALGQVPQFAEVFRCHVGSGMTSADQC 649
            ..:.:|          .|......:|..|....:|...|.|.:|:.|.|.|:|
  Fly   686 WAKDNQDAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKC 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	160/751 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	162/749 (22%)
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	160/749 (21%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	162/750 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920