DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl4 and phex

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001307259.1	Gene:	phex / 386969	ZFINID:	ZDB-GENE-030103-2	Length:	745	Species:	Danio rerio

Alignment Length:	749	Identity:	164/749 - (21%)
Similarity:	281/749 - (37%)	Gaps:	160/749 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SVPVKANDPEQSC--PYLGECNSTINQQHIDTLMSYVDSEKNPCEDFYAYACGKWRAKHGSHTTA 82
            :|..||:: |..|  |:..|...:|        :|.:|...:||:|||.||||.|..::.....:
Zfish    41 TVSQKASN-EDLCLGPHCVEAAGSI--------LSKMDQSVDPCDDFYQYACGGWLRENPIPEDS 96

  Fly    83 TMISESQINRQYEDLFL-QLLRNP-SAPEYGYPMFAKVLAHYQSCI---ALEKPDLRRYIELLDR 142
            :........||..||.| :||..| .:.:......||||  |.||:   |||..|....::.|.:
Zfish    97 SSYGIYPWLRQNVDLKLKELLEQPVRSGDIEAVKKAKVL--YASCMNESALEIEDANPLLKNLKQ 159

  Fly   143 ---------DLLASLNSTHWM----HLLAALGRYGYHGHYVQVEVRWY------NATHHMIFLLP 188
                     |.|.|  |:.|:    :||..|.:.... |...|.:|.:      |:..::|.|
Zfish   160 KEFRWPVLGDALGS--SSRWVESQFNLLETLAQIRSQ-HSKSVLIRLFVAPDDKNSNQYIIKL-- 219

  Fly   189 HNRHLNLSLTQD------------------IYDALSQDGSSWPPLHQLQEQFRSLEQNLVRLAKP 235
            ....|:||..:|                  :.|.....|:|........:.....|..|.::..|
Zfish   220 DQASLSLSSREDYITNTTEAQMYREALLRLMVDVSVMLGASEQAAEAQMKSVLDFEMKLAQIVIP 284

  Fly   236 H---SADDTFRNYSLDQIRTEVPGLHWDEALRTQLG--RSVPGNHVF---QVDDLDAI------- 285
            :   ::::.:..|||.:::..||..:|       ||  |:|....::   ::...:.:
Zfish   285 YENRTSENMYNKYSLSKLQRTVPDFNW-------LGFVRAVIDTELYPDLKISSSEQVIVRAPQY 342

  Fly   286 -EGLVEYLNTVDTLLLNRYSL------------ARFLSHLLELPHNPLATWESGQRSRGRNCIRH 337
             :.|.:.:|..||..:..|.:            .|||...|:...  :.|..:....|...|:.:
Zfish   343 FKDLFKLINATDTRTVANYVIWRSVFSRITTLSRRFLYRYLDFAR--VTTGTTSLTPRWDKCVNY 405

  Fly   338 MRRS-VYLPMNYVYERSFYSRRRHADELVIHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVH 401
            :..: :|.......::.|...::|..|.:|:.:.......||   :.|.: :.::..:....|.|
Zfish   406 VENTLIYAAGRLFVDKHFQEDKKHMMEELINGIRWAFIDILE---KENEW-MDEETKRKAIDKAH 466

  Fly   402 QMRINVGNLPPNVTEQFYWDSD--RRWSVGRDFYENHLNSLLYYYTLVADLESSSDQEERDI-WY 463
            .:...|| .|..:....|.:.|  |......|::.|.:.:|.:.             .:.|| |.
Zfish   467 AVLPKVG-YPDFILNDTYINEDIKRLAFTMTDYFGNVMQTLKFI-------------AQSDIGWL 517

  Fly   464 SFNMHTPEFPDNIDATPYFYCLG-NIIFVPYSYVKRPFF-DANFWPALLYGDLANTLGHEIMHAF 526
            ...:...|:..|......||... |.|..|...:::||| ..|:..:|.||.:...:|||:.|.|
Zfish   518 RKTVPRTEWFTNPTTVNAFYSSSTNQIRFPAGELQKPFFWGLNYPRSLSYGAIGVIVGHELTHGF 582

  Fly   527 DTDLVDYDAQGNL---------RNFSDQLG-EVELYNG----AVGCLNSSAVMLNERTSDVSGSR 577
            |.:...||..|||         ..|:::.. .::.||.    ..|........|.|..:|..|.|
Zfish   583 DNNGRKYDKDGNLDQWWSNSSINRFTEKTQCMIDQYNSYYWKEAGLNVKGKRTLAENIADNGGIR 647

  Fly   578 LAMQTYGGDWLTRSGNG--------------RLYFLQFAHFFCG-----DEGDQY----HDSGSQ 619
            .:.:.| ..|:.:...|              :|:||.:||..|.     ...||.    |.....
Zfish   648 ESFRAY-RRWVEKERGGVEEPLLPGVGLTHNQLFFLSYAHVRCNAYRPEAARDQIQSGAHSPPKY 711

  Fly   620 RLNYALGQVPQFAEVFRCHVGSGMT-SADQCPFW 652
            |:..|:....:|.:.|.|...|.|. .|:.|..|
Zfish   712 RVIGAMSNFEEFRKAFNCPETSIMNRGAESCRVW 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	152/704 (22%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	152/703 (22%)
phex	NP_001307259.1	PepO	61..744	CDD:226118	156/725 (22%)
phex	NP_001307259.1	M13	72..743	CDD:189000	152/705 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920