DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nepl4 and KEL

DIOPT Version :9

Sequence 1:NP_609019.1 Gene:Nepl4 / 33889 FlyBaseID:FBgn0031805 Length:652 Species:Drosophila melanogaster
Sequence 2:XP_005250050.1 Gene:KEL / 3792 HGNCID:6308 Length:744 Species:Homo sapiens


Alignment Length:775 Identity:172/775 - (22%)
Similarity:287/775 - (37%) Gaps:209/775 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MVQNLWTALLLLGSATCGSSVPVKANDPEQSC---PYLGECNSTINQQHIDTLMSYVDSEKNPCE 62
            :.:.:.||:|:||...| .||.:..|  .|:|   |    |.:::.....|..::..::...||.
Human    56 VARRVLTAILILGLLLC-FSVLLFYN--FQNCGPRP----CETSVCLDLRDHYLASGNTSVAPCT 113

  Fly    63 DFYAYACGKWRAKHGSHTTATMISESQINRQYEDLFLQLLRNPSAPEYGYPMFAKVLAHYQSC-- 125
            ||:::|||  |||..:::...:.:::: ||....|.:|...:|.:.|      .|....|.||  
Human   114 DFFSFACG--RAKETNNSFQELATKNK-NRLRRILEVQNSWHPGSGE------EKAFQFYNSCMD 169

  Fly   126 -IALEKP---DLRRYIELLDRDLLA----SLNSTHWMHLLAALGRYGYHGHYVQVEVRWYNATHH 182
             :|:|..   .||:.||.|....::    |||....:.||  :.:||:...:     |.|...| 
Human   170 TLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLL--MSQYGHFPFF-----RAYLGPH- 226

  Fly   183 MIFLLPHNRHLN-LSLTQDIYDALSQDGSSWPPLHQLQEQ------FR----------------- 223
                 |.:.|.. :.:.|..:|.         ||.|.|||      ||                 
Human   227 -----PASPHTPVIQIDQPEFDV---------PLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDP 277

  Fly   224 -----------SLEQNLVRLAKP----HSADDTFRNYSLDQIRTEVPGLHWDEALR-TQLGRSVP 272
                       |:...|.:..:|    .:....|:..::||::...|.:.|...|: |....|:.
Human   278 SKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLS 342

  Fly   273 GNHVFQVDDLDAIEGLVEYLNT----VDTLLLN----------------------------RYSL 305
            .:....|.|       ||||..    |:.:||.                            |..|
Human   343 PSQSLVVHD-------VEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKL 400

  Fly   306 ARFLSHLLELPHNPLATWESGQRSRGRNCIRHMRRSVYLPMNYVYERSFY--SRRRHADELVIHS 368
            ::.|..|.|.|..|       .|.|...|:..........:..::.|..:  |.|..|.:|    
Human   401 SQKLRELTEQPPMP-------ARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKL---- 454

  Fly   369 VFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVG----NLPPNVTEQFYWDSDRRWSVG 429
             |..::..|..|:::..: ::::.....|.||.|:::.:|    .|.|.:..|.|.|.    .:|
Human   455 -FTAIRDALITRLRNLPW-MNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDI----QLG 513

  Fly   430 RDFYENHLNSLLYYYTLVADLESSSDQEERDIWYSFNMHTPEFPDNI---DATPYFYCLGNIIFV 491
            ..|    |.|:|   :.|..|.:.       |..||....|:....:   |...|:....:::..
Human   514 SSF----LQSVL---SCVRSLRAR-------IVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVF 564

  Fly   492 PYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNLRNFSDQLGEVELYNGAV 556
            |...::.|||...:..|:.:|...:.:.||::|.|...|:   ..|.|...:..|.|..|     
Human   565 PAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLL---PGGCLACDNHALQEAHL----- 621

  Fly   557 GCL---------------NSSAVMLNERTSDVSGSRLAMQTYGGDWLTRSGN----------GRL 596
             ||               |.|...| |..:||.|..:|:|.|....|...|.          .::
Human   622 -CLKRHYAAFPLPSRTSFNDSLTFL-ENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQI 684

  Fly   597 YFLQFAHFFCGDEGDQ-YHDSGSQ---RLNYALGQVPQFAEVFRCHVGSGMTSADQCPFW 652
            :|..:|...|.....| .||:.|.   |::..|...|.||..|||..|:.:..:.:|..|
Human   685 FFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 744

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nepl4NP_609019.1 PepO 51..643 CDD:226118 156/711 (22%)
GluZincin 59..649 CDD:301352 156/709 (22%)
KELXP_005250050.1 PepO 106..744 CDD:226118 157/716 (22%)
M13 109..742 CDD:189000 156/711 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG3590
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D282463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11733
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.880

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