DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and Nep3

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001245775.1	Gene:	Nep3 / 33005	FlyBaseID:	FBgn0031081	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	786	Identity:	163/786 - (20%)
Similarity:	294/786 - (37%)	Gaps:	194/786 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVQNLWTALLLL---GSATCGSSVPVKANDPEQSCPYLGE--CNSTINQQHI---DTLMSYVDSE 57
            |...::|.|::|   |.::..:...:.....::.||...|  |   :|:..|   ..::..:|..
  Fly    61 MAITIFTLLIVLFTDGGSSDATKHVLHVQPHQKDCPSGNELPC---LNKHCIFASSEILKSIDVT 122

  Fly    58 KNPCEDFYAYACGKWRAKH----GSHTTATMISESQINRQYEDLFLQLLRNPSAPEYGYPMFAKV 118
            .:||:|||.|:|.:|...:    |..|..|.....|:|:    |.::.:....|..:......|.
  Fly   123 VDPCDDFYGYSCNQWIKNNPIPEGKSTWGTFGKLEQMNQ----LIIRNVLEKPAKSFKSDAERKA 183

  Fly   119 LAHYQSCIALEKPDLRRYIELLD----RDLLASL----------NSTHWM--HLLAAL-GRYGYH 166
            ..:|:||:     |...::|.|.    .|||..:          |..:|.  |.|..| .:|.::
  Fly   184 KVYYESCL-----DADEHMEKLGAKPMNDLLLQIGGWNVTKSGYNVANWTMGHTLKILHNKYNFN 243

  Fly   167 ---GHYVQVEVRWYNATHHMI------FLLP-----------HNRHLN----------LSLTQDI 201
               |..:..:.:  |::.|:|      ..||           |.:.||          :.|..:.
  Fly   244 CLFGWAIGEDDK--NSSRHVIQIDQGGLTLPTADYYNNKTDNHRKVLNEYIEYMTKVCVLLGANE 306

  Fly   202 YDALSQDGSSWPPLHQLQEQFRSLEQNLVRLAKP----HSADDTFRNYSLDQIRTEVPGLHW--- 259
            .||.:|           .....:.|:.|..:..|    .:.:..:....|.|:....|.|:|
  Fly   307 SDARAQ-----------MIGVINFEKKLANITIPLEDRRNEEAMYHPMQLRQLSKLAPFLNWTDH 360

  Fly   260 -DEALRTQLGRSVPGNHVFQVDDLDAIEGLVEYLNTVD-----TLLLNRYSLARFLSHLLELPHN 318
             |.|:: .:||.|..:.|..|...|.::.|.:.:..::     .:.||.|.:.:.:..|......
  Fly   361 FDNAMQ-MVGRRVTDDEVVVVYAPDFLKNLSDIILKMEQTEEGKITLNNYLVWQAVRTLTSCLSK 424

  Fly   319 PLATWESGQR-----SRG-----RNCIRHMRRSVYLPMNYVYER-SFYSRRRHADELVIHSVFQQ 372
            |......|.|     |.|     |.|:......|...:..::.| :|:...:.|.|.:|    .:
  Fly   425 PFRDAYKGVRKALMGSDGGEEIWRYCVSDTNNVVGFAVGAIFVRQAFHGESKPAAEQMI----AE 485

  Fly   373 LQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVG------------------NLPPNVTEQFY 419
            ::...::.:|:..:...|...|::: |.:|:...:|                  |:.||.
  Fly   486 IREAFKMNLQNLTWVDKQTREKAIE-KANQISDMIGFPDYILDPVELDKKYAELNITPNA----- 544

  Fly   420 WDSDRRWSVGRDFYENHLNSLLYYYTLVADLESSSDQEERDIWYSFNMHTPEFPDNIDATPYFYC 484
                        ::||::...:  |.|.::|:.......:..|       ...|..::|  |:..
  Fly   545 ------------YFENNIQVAI--YNLKSNLKRLDQPVNKTNW-------GMTPQTVNA--YYTP 586

  Fly   485 LGNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNLRNFSDQLGEV 549
            ..|.|..|...::.||||.|...:|.:|.:...:|||:.||||....:||..||:..:.|. ..:
  Fly   587 TKNQIVFPAGILQTPFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRWWDS-KSI 650

  Fly   550 ELYNGAVGCL--NSSAVMLNERT-----------SDVSGSRLAMQTY-------GGDWLTRSG-- 592
            |.:|....|:  ..|...:|.||           :|..|.:.|...|       ..|.|...|
  Fly   651 ERFNEKSECIARQYSGYKMNGRTLNGKQTLGENIADNGGLKAAYHAYQRTKSDRDVDILKLPGLN 715

  Fly   593 --NGRLYFLQFAHFFCGDEGDQY---------HDSGSQRLNYALGQVPQFAEVFRCHVGSGMTSA 646
              :.:|:|:.||..:|....|:.         |.....|:...|..:.:|||||:|..|..|...
  Fly   716 LTHSQLFFVSFAQVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKPGKRMNPT 780

  Fly   647 DQCPFW 652
            ::|..|
  Fly   781 EKCEVW 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	149/717 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	149/715 (21%)
Nep3	NP_001245775.1	M13	123..784	CDD:189000	149/717 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920