DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and Nep1

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster

Alignment Length:	733	Identity:	152/733 - (20%)
Similarity:	270/733 - (36%)	Gaps:	167/733 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GECNSTINQQHIDT---LMSYVDSEKNPCEDFYAYACGKWRAKHGSHTTATMISESQINRQYEDL 97
            |:.|..:.|:.:.|   |:|.:|...:|||||:.||||.|...|......:.||..::....:.:
  Fly   168 GQDNICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQV 232

  Fly    98 FLQLLRNPSAPEYGYPMFAKVLAHYQSCIALEKPDLRRYIELLDRDLLASLNSTHWMHLLAALGR 162
            .|:.:......|.......|....::||  ::.|.:|:            :.:.....:|.:||.
  Fly   233 ILRAVLEEPIDERDNKATIKAKTFFKSC--MDIPQIRK------------IGTGRLKQVLQSLGG 283

  Fly   163 YGYHGHYVQVEVRWYNATHHMIFLLPHNRHLNLS--LTQDIYDALSQDGSSWPPLH--QLQ---- 219
            :..      :|..|.......:..|.....||.|  :..::|.......||...|.  |||
  Fly   284 WPV------IERNWSPPADLSVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALP 342

  Fly   220 ---------------------------------------EQFRSLEQNLVRLAKP----HSADDT 241
                                                   |:....|..||.::.|    |.....
  Fly   343 SRDYYLKESSANDRRAYHRYMTQVALLLGADPATAAAELEKVVLFETQLVNVSLPEADRHDTSLV 407

  Fly   242 FRNYSLDQIRTEVPGLHWDEALRTQLGRSVPGNHVFQVDDLDAIEGLVEY-----------LNTV 295
            :|...|.:::..||.:.|.|.|:..||..:|         |...|.||.|           |...
  Fly   408 YRKMLLPELQELVPEVQWQEYLQAALGPGIP---------LQEDEPLVTYGLHYLTEMGKILAHT 463

  Fly   296 DTLLLNRYSLAR----FLSHLLE------LPHNPLATWESGQRSRGRNCIRHMRRSVYLPMNYVY 350
            |..:::.|.|.|    .:||:::      :....:......:|:|...|:....:.:.:.:..::
  Fly   464 DRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALF 528

  Fly   351 ERSFYSRRRHADEL-VIHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPPNV 414
            .|..:::......| :||::.....   ||..:::..:.....|...:|.....||....|..|.
  Fly   529 IRDNFNQESKEVALEMIHTIRAAFN---ELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNA 590

  Fly   415 T--EQFYWDSDRRWSVGRDFYENHLNSLLYYYT--LVADLESSSDQEERDIWYSFNMHTPEFPDN 475
            |  ||.|.:    .::..|.:.|::.|:|.:.:  ::..|....|:|:   |      |.| |..
  Fly   591 TELEQEYVN----LTIVPDNFINNVLSILQWESEKMLRLLRQPVDKEK---W------TTE-PAV 641

  Fly   476 IDATPYFYCLG-NIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNL 539
            ::|   ||... |.|..|...::..|:..:|..:|.||.:...:||||.|.||.....:|.:||:
  Fly   642 VNA---FYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNM 703

  Fly   540 RNFSDQLGEVELYNGAVGC---------LNSSAVMLN------ERTSDVSGSRLAMQTYGGDWLT 589
            ..:.:. ..:|.:.....|         :|...:.::      |..:|..|.:.|.:.| ..|.|
  Fly   704 MQWWNN-ATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAY-KKWET 766

  Fly   590 RSG-----------NGRLYFLQFAHFFCGDEGDQ---------YHDSGSQRLNYALGQVPQFAEV 634
            ..|           :.:|:||.:|..:||....:         .|..|..|:...|.....||..
  Fly   767 LHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASA 831

  Fly   635 FRCHVGSGMTSADQCPFW 652
            ::|.:||.|..|::|..|
  Fly   832 YKCPLGSTMNPAEKCSVW 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	143/704 (20%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	143/702 (20%)
Nep1	NP_001284925.1	M13	194..847	CDD:189000	143/703 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920