DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl4 and Mmel1

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_038811.2	Gene:	Mmel1 / 27390	MGIID:	1351603	Length:	766	Species:	Mus musculus

Alignment Length:	738	Identity:	155/738 - (21%)
Similarity:	273/738 - (36%)	Gaps:	194/738 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LMSYVDSEKNPCEDFYAYACGKWRAKHGSHTTATMISESQINRQYEDLFLQLLRNPSAPEYGYPM 114
            ::..:|..:||||:||.||||.|...|....|.:..|...|.|...::.|:.:...|..:: .|.
Mouse    88 ILENMDQSRNPCENFYQYACGGWLRHHVIPETNSRYSVFDILRDELEVILKGVLEDSTSQH-RPA 151

  Fly   115 FAKVLAHYQSCI---ALEKPDLRRYIEL-----------------------LDRDLLASLNSTHW 153
            ..|....|:||:   .:||.|....:.:                       |:|. ||.|||...
Mouse   152 VEKAKTLYRSCMNQSVIEKRDSEPLLSVLKMVGGWPVAMDKWNETMGLKWELERQ-LAVLNSQFN 215

  Fly   154 MHLLAALGRYGYHGHYVQVEVRW---YNATHHMIFL------LP--------HNRH----LNLSL 197
            ..:|..|        ::     |   .|::.|:|::      :|        .|.|    ..|..
Mouse   216 RRVLIDL--------FI-----WNDDQNSSRHVIYIDQPTLGMPSREYYFQEDNNHKVRKAYLEF 267

  Fly   198 TQDIYDALSQDGSSWPPLHQLQEQFR---SLEQNLVRLAKPHSA--DDTFRNYSLD----QIRTE 253
            ...:...|.:|.:.......::|:..   .||.:|.....|...  |.|...:.:|    |.|..
Mouse   268 MTSVATMLRKDQNLSKESAMVREEMAEVLELETHLANATVPQEKRHDVTALYHRMDLMELQERFG 332

  Fly   254 VPGLHWDEALRTQLGRSV-----PGNH--VFQVDDLDAIEGLVEYLN--TVDTLLLNRYSLARF- 308
            :.|.:|...::..|. ||     |...  |:.:..|:.:|.:::..:  |:...|:.|..|.|.
Mouse   333 LKGFNWTLFIQNVLS-SVEVELFPDEEVVVYGIPYLENLEDIIDSYSARTMQNYLVWRLVLDRIG 396

  Fly   309 -LSHLLE---LPHNPLATWESGQRSRGRNCIRHMRRSVYLPMNYVYERSFYSR--RRHADELV-- 365
             ||...:   :.:.......:.:..|.|.|:.::..::...:..:|.:..:|:  :....||:
Mouse   397 SLSQRFKEARVDYRKALYGTTVEEVRWRECVSYVNSNMESAVGSLYIKRAFSKDSKSTVRELIEK 461

  Fly   366 IHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPPNVTEQFYWDSDRRWSVGR 430
            |.|||.....:|..        :.::..|..|.|...:|..:| .|..:.|......|..:| ..
Mouse   462 IRSVFVDNLDELNW--------MDEESKKKAQEKAMNIREQIG-YPDYILEDNNKHLDEEYS-SL 516

  Fly   431 DFYENHLNSLLYYYTLVADLESSS--------DQEERDIW----------YSFNMHTPEFPDNID 477
            .|||:     ||:...:.:|::::        ::.::::|          ||.|.:...||..|
Mouse   517 TFYED-----LYFENGLQNLKNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNQIVFPAGI- 575

  Fly   478 ATPYFYCLGNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNL--- 539
                              ::.|||..:...:|.:|.:...:||||.|.||.:..::|..||:
Mouse   576 ------------------LQPPFFSKDQPQSLNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDW 622

  Fly   540 --------------------RNFSDQLGEVELYNGAVGCLNSSAVMLNERTSDVSGSRLAMQTYG 584
                                .|||.:|.:.:..||        ...|.|..:|..|.|.|.:.|
Mouse   623 WSNFSARHFQQQSQCMIYQYGNFSWELADNQNVNG--------FSTLGENIADNGGVRQAYKAY- 678

  Fly   585 GDWLTRSGN-----------GRLYFLQFAHFFCGDEGDQY---------HDSGSQRLNYALGQVP 629
            ..||...|.           .:|:|:.:|..:||....::         |.....|:..:|..:|
Mouse   679 LRWLADGGKDQRLPGLNLTYAQLFFINYAQVWCGSYRPEFAVQSIKTDVHSPLKYRVLGSLQNLP 743

  Fly   630 QFAEVFRCHVGSGMTSADQCPFW 652
            .|:|.|.|..||.|....:|..|
Mouse   744 GFSEAFHCPRGSPMHPMKRCRIW 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	152/726 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	152/724 (21%)
Mmel1	NP_038811.2	PepO	89..766	CDD:226118	154/735 (21%)
Mmel1	NP_038811.2	M13	97..764	CDD:189000	152/725 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020