DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and Ece1

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001356106.1	Gene:	Ece1 / 230857	MGIID:	1101357	Length:	769	Species:	Mus musculus

Alignment Length:	797	Identity:	155/797 - (19%)
Similarity:	280/797 - (35%)	Gaps:	229/797 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QNLWTA-------------LLLLGSATCGSSVPVKANDPEQSCPYLGECNSTINQQHIDTLMSYV 54
            |..|.|             ||..|...|.:::.::.............|.|..:     ::::.:
Mouse    55 QRCWAARTSVEKRLVVLVTLLAAGLVACLAALGIQYQTRTPPVCLTEACVSVTS-----SILNSM 114

  Fly    55 DSEKNPCEDFYAYACGKW-RAK-----HGSHTTATMISESQINRQYEDLFLQLLRNPSAPEYGYP 113
            |...:||:||::||||.| :|.     |....|.:.:.|..     :.:...||.|.:|......
Mouse   115 DPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHN-----QAVIKHLLENATASVSEAE 174

  Fly   114 MFAKVLAHYQSCIALEKPDLRRYIELLDRDLLASLNSTHWMHLLAALGRYGYHGHYVQ------- 171
            ..|:|  :|::|              ::...:..|.:...|.|:..||.:...|.:.:
Mouse   175 RKAQV--YYRAC--------------MNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTL 223

  Fly   172 --VEVRWYNATHHMIFLLPHNRHLNLSLTQ-----------DIY--------------------- 202
              |...:..:....:::...:::.|.::.|           |.|
Mouse   224 QVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLG 288

  Fly   203 --------DALSQDGSSWPPLHQLQEQFRSLEQNLVRLAKPHSADDTFRNYSLDQIRTEVPGLHW 259
                    ||:.      |.:.|:.:...:|....:...|....:..:...:..:::|..|.::|
Mouse   289 KLLGGGDEDAIR------PQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINW 347

  Fly   260 DEALRTQLGRSVPGNHVFQVDDLDAIEGLV----EYLNTVDTL-------LLNRY---SLARFLS 310
            ...|.|          :|...:::..|.:|    |||..|.||       |||.|   :|.|..|
Mouse   348 LPFLNT----------IFYPVEINESEPIVVYDKEYLRQVSTLINNTDKCLLNNYMMWNLVRKTS 402

  Fly   311 HLLELPHNPLATWESGQR--------------------SRGRNCIRHMRRSVYLPMNYVYERSFY 355
            ..|:            ||                    .|.:.|:.....::...:..::.::.:
Mouse   403 SFLD------------QRFQDADEKFMEVMYGTKKTCIPRWKFCVSDTENNLGFALGPMFVKATF 455

  Fly   356 SR--RRHADELV--IHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPPNVTE 416
            :.  :..|.|::  |...|::..|.|:.        :.::..:|.:.|...:...:|.  ||
Mouse   456 AEDSKNIASEIIMEIKKAFEESLSTLKW--------MDEETRRSAKEKADAIYNMIGY--PN--- 507

  Fly   417 QFYWDSDRRWSVGRD-------FYENHLNSLLYYYTLVAD-LESSSDQEERDIWYSFNMHTPEFP 473
             |..|......|..|       ::||.:....:.:.:.|| |..:.:   ||.|    ..||..
Mouse   508 -FIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPN---RDQW----SMTPPM- 563

  Fly   474 DNIDATPYFYCLGNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGN 538
                ...|:....|.|..|...::.||:..:...||.:|.:...:|||:.||||....:||..||
Mouse   564 ----VNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGN 624

  Fly   539 LRNFSDQLGEVELYNGAVGCL---------NSSAV----MLNERTSDVSGSRLAMQTYGGDWLTR 590
            ||.:... ..||.:.....|:         |...|    .|.|..:|..|.:.|.:.| .:|:.:
Mouse   625 LRPWWKN-SSVEAFKQQTECMVQQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAY-QNWVKK 687

  Fly   591 SG-----------NGRLYFLQFAHFFC-------GDEG--DQYHDSGSQRLNYALGQVPQFAEVF 635
            :|           :.:|:||.||..:|       ..||  ...|.....|:..:|....:|:|.|
Mouse   688 NGAEQTLPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHF 752

  Fly   636 RCHVGSGMTSADQCPFW 652
            ||..||.|....:|..|
Mouse   753 RCPPGSPMNPHHKCEVW 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	143/725 (20%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	143/723 (20%)
Ece1	NP_001356106.1	M13	118..767	CDD:341056	143/725 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920