Protein Alignment Nepl4 and nep-24

DIOPT Version :9

• Sequence 1: NP_609019.1
• Gene: Nepl4 / 33889
• FlyBaseID: FBgn0031805
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_503005.3
• Gene: nep-24 / 190993
• WormBaseID: WBGene00013786
• Length: 567
• Species: Caenorhabditis elegans
• Alignment Length: 651
• Identity: 133/651 - (20%)
• Similarity: 217/651 - (33%)
• Gaps: 220/651 - (33%)

  Fly     9 LLLLGSATCGSSVPVKANDPEQSCPYLGECN--STINQQHIDTLMSYVDSEKNPCEDFYAYACGK 71
            ||||   ||.:.:.:.|..|...    ..||  :.|...|:  |.:|.|...:||::|:.:|||:
 Worm    16 LLLL---TCTAPLAIGATTPATR----NVCNTPACITLAHM--LHNYHDPSVDPCDNFHQFACGR 71

  Fly    72 WRAKHGSHTTATMISESQINRQYEDLFLQLLRNPSAPEYGYPMFAKVLAHYQSCIALEKPDLRRY 136
               :| .|.|..:.::.  .:...::..:.|:.............:.|  |::|..|||
 Worm    72 ---EH-EHETEDIYTKK--TKTINNIMKRFLKKNETSRSKSENAMRTL--YKACKTLEK------ 122

  Fly   137 IELLDRDLLASLNSTHWMHLLAALGRYGYHGHYVQVEVRWYNATHHMIFLLPHNRHLNLSLTQDI 201
                        |||                                   ...|:.|     |||
 Worm   123 ------------NST-----------------------------------ASRNKAL-----QDI 135

  Fly   202 YDALSQDGSSWPPLHQLQEQ----FRSLEQNLVRLAKPHSADDTFRNYSLDQIRTEV-------- 254
            :..:...| :||.:....::    ......|||||.:        :|:.|.|:...|
 Worm   136 FQDIQSIG-AWPVVDDKWDESKFDLNDFLVNLVRLGR--------KNFGLFQMARYVNVRNFAIG 191

  Fly   255 PGLHWDEALRTQLGRSV----PGNHVFQVDDLDAIEGLVEYLNTVDTLLLNRY------------ 303
            |...|..  ...||:::    ..|.| |.::...::.|.||:|....|..:::
 Worm   192 PEAAWRH--NVDLGKTISEILKANSV-QTNNKKLLDDLAEYVNLEKALSQHKFNTVQPGYIFSER 253

  Fly   304 ----SLARFLSHLLEL--PHNPLATWESGQRSRGRNCIRHMRRSVYLPMNYVYERSFYSRRRHAD 362
                |...|...:||:  |..                 |.:...||..|.......|:.:..:.:
 Worm   254 SDFVSSVNFSRLVLEMMSPDK-----------------RTLFPEVYQIMYLTNTSLFFGKNNNLE 301

  Fly   363 ELVIHSVFQQLQSQLELRVQHNAFNLSQDLV-KSLQAKVHQMRINVGNLPPNVTEQFY------- 419
            .::.::..:.|.:.|..:....:.   .||. .|..|...|..||.  ||......||
 Worm   302 TIIRNTSKRALANYLIFKFIDTSI---ADLTYGSPSAFCEQKVINF--LPRAALRAFYRNFISKE 361

  Fly   420 ------------------------WDS--------DRRWSVGR-----DFYE---------NHLN 438
                                    |.|        ||..|:..     |:::         .|||
 Worm   362 NRKKITKLTEATQVQLLKIIGATDWMSIKSKKIAMDRVSSMNMVIGYPDYFDPPGKLDGLFEHLN 426

  Fly   439 --SLLYYYTLVADLESSSDQEERDIWYSFNMHTPEFPDNIDATPYFYCLGNI-IFVPYSYVKRPF 500
              |...|||:|..:.....::|.|.:.....:.|.||..:....|.....|: ||.|  :...||
 Worm   427 LSSSDTYYTVVRKINRFMREQEMDYYTGEVPYYPLFPGLMTNAMYNANDNNLMIFAP--FFDDPF 489

  Fly   501 FDANFWPALLYGDLA---NTLGHEIMHAFDTDLVDYDAQGNLRNFSDQL----GEVELYNGAVGC 558
            ||::| |.  |.::|   |||.||:.|.|...|:|      :...:.::    .|.|.|...|.|
 Worm   490 FDSSF-PD--YANIAFTSNTLAHEMGHTFSPHLMD------IMTGTTEVWLTPKETEEYEKRVKC 545

  Fly   559 L 559
            |
 Worm   546 L 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	120/607 (20%)
		GluZincin	59..649	CDD:301352	118/599 (20%)
nep-24	NP_503005.3	GluZincin	58..561	CDD:301352	118/600 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920