DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and nep-18

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_494297.1	Gene:	nep-18 / 186911	WormBaseID:	WBGene00019343	Length:	701	Species:	Caenorhabditis elegans

Alignment Length:	793	Identity:	168/793 - (21%)
Similarity:	273/793 - (34%)	Gaps:	243/793 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LWTALLLLGSATCGSSVPVKANDPEQSCPYLGECNSTINQQHIDTLMSYVDSEKNPCEDFYAYAC 69
            ||.:|...||    |:.|   |...::| :..||...:..     :.:|.::..:|||||:.:.|
Worm     7 LWASLWPSGS----SNAP---NGSPETC-WSKECVGVLAM-----IKNYQNASVDPCEDFFEHTC 58

  Fly    70 GKWRAKHGSHTTATMISESQINRQYEDLFLQLL-------RNPSAPEYGYPMFAKVLAHYQSCIA 127
            |:: ::|      .|...|....||:.|..|:.       :..|.|.....:|.|      ||:.
Worm    59 GRY-SEH------VMDDNSWGYVQYKQLLYQVFAIARKTNKFNSKPNEQLRIFTK------SCLD 110

  Fly   128 LEK------PDLRRYIE------LLD----------RDLLA---SLNSTHWMHL----LAAL-GR 162
            .::      .|||..||      ::|          .|:||   |:|......|    .||: |.
Worm   111 RKEMDEDTFQDLRNDIEERGGFPMIDPNWNEEKFDLSDMLAKYLSINRNRMGFLSVEPYAAIEGN 175

  Fly   163 YGYHGHYVQVEVRW-YN-------ATHHMIFLLP-----HNRHLNLSLTQDIYDALSQDGSSWPP 214
            ...:..||.....| ||       ....:.|:|.     .||.||    :.|||      ..:..
Worm   176 KSVNRLYVSPGPHWVYNWAMGISIYKDSVAFMLRRLLKLENRELN----ETIYD------KEFAE 230

  Fly   215 LHQLQEQFRSLEQNLVRLAKPHSADDTFRNYSLD-----------QIRTEVPGLHWDEALRTQLG 268
            |.||:..|.:|            ||  :||.:||           .:...:|.:.|.:.|:. |.
Worm   231 LVQLEANFSTL------------AD--YRNLALDNDNMSKSRNLTDLVKMIPEIDWIKILKA-LA 280

  Fly   269 RSVPGNHVFQVDDLD------AIEGLVEYLNTVDTLLLNRYSLARFLSHLLELPHNPLATW---- 323
            |     |....:|.:      .:.|..||.     ...|| .|||..:   |.|.:.||.:
Worm   281 R-----HGTSEEDEEKLLERVTVHGAGEYF-----FGENR-ELARIAT---ETPKSALANYLVVR 331

  Fly   324 ------------ESGQRSRGRN-------CIRHMRRSVYLP-MNYVYERSFYSRRRHADEL-VIH 367
                        :..::::..|       |...:.....:| ||...|.|.:.    .:.| ||.
Worm   332 QLIDVALYFYDKDQPRQNKFYNHVDQQSFCATQVASFFPMPSMNVFIESSQFK----IENLKVIE 392

  Fly   368 SVFQQLQSQLELRVQHNAF---NLSQDLVKSLQAKVHQMRINVGNLPPNVTEQFY-----WDSDR 424
            .:|.:::::.|.....|.:   .:.:.|::.|.|...:..::.......:.|:.|     .|:|.
Worm   393 EMFVKIKAEYEQIFTENEYLELEIREFLIRKLNAIDGKFGLDQYTEGKPLLEKMYETLNFLDTDS 457

  Fly   425 RWSVGRDFYENHLNSLLYYYTLVADLESSSDQEERDIWYSFNMHTPEFPDNIDA-------TPYF 482
            .|.|....:.:....|:.:  :|.|                   ||..|.|:..       .||
Worm   458 PWQVYMKMWRHWSEQLVEH--IVHD-------------------TPLDPVNLKMFGTHAAYQPY- 500

  Fly   483 YCLGNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNLRN--FSDQ 545
               .|..::...|:..|:.||:|.....||.|...:||||.||||......|..|..:.  |::.
Worm   501 ---PNHFYINLPYLTYPWMDADFPANTNYGYLGYVIGHEIGHAFDHFHRKLDESGRQQQYWFTET 562

  Fly   546 LGEVELYNGAVGCLNSSAVMLNERTSD--VSGSRLAMQTYGGDWLTRS----------------- 591
            ......|.....||........|...|  ::|:....:..|.....|:
Worm   563 NSSNTEYELREKCLRDQYSAYKEPGYDFFMNGTHCRYEIAGDHMGIRTAFRVFEKVKKEDRFRLP 627

  Fly   592 ----GNGRLYFLQFAHFFCGDEGDQY-------------HDSGSQRLNYALGQVPQFAEVFRCHV 639
                ...:|:|..:|...|    |.|             |.:...|:|..:..:|:|||.|.|..
Worm   628 GLEMSEEQLFFYNYAFRQC----DVYNPNKLPRNMLARQHPTNRYRVNGVIQNIPEFAEAFNCPK 688

  Fly   640 GSGMTSADQCPFW 652
            .|.|....:|..:
Worm   689 NSPMNPEMKCKLY 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	155/736 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	155/734 (21%)
nep-18	NP_494297.1	PepO	42..692	CDD:226118	155/734 (21%)
nep-18	NP_494297.1	M13	47..699	CDD:189000	155/736 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880