Protein Alignment Nepl4 and Phex

DIOPT Version :10

• Sequence 1: NP_609019.1
• Gene: Nepl4 / 33889
• FlyBaseID: FBgn0031805
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_035207.1
• Gene: Phex / 18675
• MGIID: 107489
• Length: 749
• Species: Mus musculus
• Alignment Length: 754
• Identity: 158/754 - (20%)
• Similarity: 256/754 - (33%)
• Gaps: 221/754 - (29%)

  Fly    50 LMSYVDSEKNPCEDFYAYACGKWRAKHGSHTTATMISESQINRQYEDLFLQLLRNPSAPEYG-YP 113
            :||.|:...:|||:|:.:||..|            ||.:.|.   ||:          |.|| ||
Mouse    66 IMSKVNLSVDPCENFFRFACDGW------------ISNNPIP---EDM----------PSYGVYP 105

  Fly   114 MF---------------------------AKVLAHYQSCI---ALEKPDLRRYIELLDRDLLASL 148
            ..                           ||:|  |.||:   |:||.|.:..:.:|..
Mouse   106 WLRHNVDLKLKALLEKSVSRRRDTEAVQKAKIL--YSSCMNEKAIEKADAKPLLHILRH------ 162

  Fly   149 NSTHWMHLLAALGRYG---------------YHGHYV-QVEVRWY-----NATHHMIFLLPHNRH 192
            :...|..|.|.:|..|               :.|.|. .|.:|.|     .|::..|..| ....
Mouse   163 SPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKL-DQAT 226

  Fly   193 LNLSLTQDIYDALSQDGSSWPPL-------------------HQLQEQFRSLEQNLVRLAKPH-- 236
            |:|::.:|..|..::..|....|                   |.::...| ||..:..:..||
Mouse   227 LSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLR-LEIKIAEIMIPHEN 290

  Fly   237 -SADDTFRNYSLDQIRTEVPGLHW--------DEALRTQLGRSVPGNHVF-----QVDDLDAIEG 287
             :::..:...::.::...:|...|        |..|...|....|..:|.     ...||..|.|
Mouse   291 RTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFKDLFRILG 355

  Fly   288 LVEYLNTVDTLLLNRYSLARF-------------LSHLLELPHNPLATWESGQRSRGRNCIRHMR 339
             .|...|:...|:.|...:|.             .|.:::.....|..|:        .|:..:.
Mouse   356 -AERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWD--------KCVNFIE 411

  Fly   340 RSVYLPMNYVYERSFYS------RRRHADELV--IHSVFQQLQSQLELRVQHNAFNLSQDLVKSL 396
            .:  ||  ||..:.|.:      ::...:||:  :...|..:..:....:.......:|:..:::
Mouse   412 SA--LP--YVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAV 472

  Fly   397 QAKVHQMRINVGNLPPNVTEQFYWDSDR---RWSVGRDFYENHLNSLLYYYTLVADLESSSDQEE 458
            .|||        ..|..:....|.:.|.   ::|.. |::.|.|.:..|.        :.||
Mouse   473 LAKV--------GYPEFIMNDTYVNEDLKAIKFSES-DYFGNVLQTRKYL--------AQSD--- 517

  Fly   459 RDIWYSFNMHTPEFPDNIDATPYFYCLG-NIIFVPYSYVKRPFFDANFWP-ALLYGDLANTLGHE 521
             ..|....:...|:..|......||... |.|..|...:::|||....:| :|.||.:...:|||
Mouse   518 -FFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHE 581

  Fly   522 IMHAFDTDLVDYDAQGNL---------RNFSDQ----LGEVELYNGAVGCLN-SSAVMLNERTSD 572
            ..|.||.:...||..|||         ..|.::    :.:...|......|| .....|.|..:|
Mouse   582 FTHGFDNNGRKYDKNGNLDPWWSVESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIAD 646

  Fly   573 VSGSRLAMQTYGGDWLT--RSG------------NGRLYFLQFAHFFCGDEGDQ---------YH 614
            ..|.|.|.:.| ..|:.  |.|            |.:|:||.:||..|.....:         .|
Mouse   647 NGGLREAFRAY-RKWINDRRQGVEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAH 710

  Fly   615 DSGSQRLNYALGQVPQFAEVFRCHVGSGMT-SADQCPFW 652
            .....|:|.|:....:|.:.|.|...|.|. .||.|..|
Mouse   711 SPPQFRVNGAISNFEEFQKAFNCPRNSTMNRGADSCRLW 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	GluZincin	59..649	CDD:472708	153/740 (21%)
Phex	NP_035207.1	M13	74..740	CDD:341056	150/735 (20%)