DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and nep-8

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001309548.1	Gene:	nep-8 / 184631	WormBaseID:	WBGene00017553	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	696	Identity:	138/696 - (19%)
Similarity:	261/696 - (37%)	Gaps:	168/696 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NLWTALLLLGSATCGSSV-PVKAN---------DPEQSC--PYLGECNSTINQQHIDTLMSYVDS 56
            ||...::.|...|....| ||..:         |.:..|  |   ||   |...|  .|::|.|.
Worm    18 NLLLLIVFLAMVTVHIKVEPVNLDELLSIGNDVDSKNLCDSP---EC---ITLSH--ELLNYQDP 74

  Fly    57 EKNPCEDFYAYACGKWRAKHGSHTTATMISESQINRQYEDL------FLQLLRNPSAPEYGYPMF 115
            ..:||.||:.::||::..:        .:|||::.::...|      ||..::|.::....   .
Worm    75 SVDPCVDFFQHSCGRFHEQ--------SVSESRLQKKKHILRKQIREFLHKIQNSTSKSEN---L 128

  Fly   116 AKVLAHYQSCIALEKPDLRRY-------------------IELLDR-------DL------LASL 148
            .|::  :..|.|.:|.....|                   ..|||:       ||      |..|
Worm   129 MKLV--FDKCEASKKTSNDNYKISRDAIHDVFNDIKKIGAWPLLDKNWDGSKFDLNEMLSNLVKL 191

  Fly   149 NSTHWMHLLAALGRYGYHGHYVQVEVRWYNATHHMIFLLPHNRHLNLSLTQDIYDALSQDGSSWP 213
            .:|: :.|.....|....|.:|::.....:..|            |.::...|.:.|..:|.. |
Worm   192 GATN-LGLFQLDFRILTEGKFVRIAPTLGSIVH------------NSTMISMISEILEANGVQ-P 242

  Fly   214 PLHQLQEQFRSLEQNLVRLAKPHSADDT------FRNYSLDQIRTEVPGLHWDEALRTQLG--RS 270
            ...::.::|.......::|||..|:...      .|:.:...:.||:  :|.....:. .|  |.
Worm   243 DSEEISKEFEEYSSLQMKLAKYQSSGKLSISLPGVRSINFSSLITEM--IHPSRVSKI-FGKIRV 304

  Fly   271 VPGNH--VFQVDDLDAIEGLVEYLNTVDTLLLNRYSLARFL-SHLLELPHNPLATWESGQRSRGR 332
            |...|  .|:.::.::::.::|..:       |: :||.|| .:.::..:|.:    .|.| ||
Worm   305 VTSEHPLFFKSNETESLDTIIESTS-------NK-TLANFLIFNYIQSSYNIM----KGAR-RG- 355

  Fly   333 NCIRHMRRSVYLPMNYVYERSFYSRRRHADELVIHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQ 397
            ||...:||........|:.|:|..:.....   :..:.::|:.. .|.:..:..||:..:.:|:.
Worm   356 NCEDDVRREFPRASLRVFMRNFVDKGNRDG---VKKLTEELKKN-TLEMIQDTENLAPPVKESML 416

  Fly   398 AKVHQMRINVGNLPPNVTEQFYWDS-DRRWSVGRDFYENHLNSLLYYYTLVADLESSSDQEERDI 461
            .||..:::.:|          |.|. |...::.::|....|:|...||.:...|.....:::.:.
Worm   417 KKVEAIKVTIG----------YPDHFDPPGTLDKEFENFDLDSTDSYYRIFQKLNRLRSEQQMEF 471

  Fly   462 WYSFNMHTPEFP--DNIDATPYFYCLGNIIFVPYSYVKRPFFDANFWPALLYGDLAN------TL 518
               ....||..|  :.:.....:....|.:.|...::..||||      :.|.|..|      .:
Worm   472 ---IAGETPISPIKEVLKVNANYKRSKNALTVFAPFLDDPFFD------ITYPDYVNLFFSGFLI 527

  Fly   519 GHEIMHAFDTDLVDYDAQG---------NLRNFSDQ----LGEVELYNGAV-GCLNSSAVMLNER 569
            .|||.|:.|.:.:.||..|         ::..:..|    :.:.:.|:..| |...:....:||.
Worm   528 AHEIGHSVDANGLGYDENGKPMDGIRLEHVTEYGKQGQCLVDQYDNYDDPVYGKKMNGTHSINEI 592

  Fly   570 TSDVSGSRLAMQTY----GGDWLTRSG-----NGRLYFLQFAHFFC 606
            .:|..|..:..:.|    ....|:..|     ..:|||...:..||
Worm   593 IADWVGHEVTWRAYKKMDTSKMLSLIGLKDINMDQLYFRVQSLLFC 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	123/637 (19%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	121/629 (19%)
nep-8	NP_001309548.1	M13	76..664	CDD:341056	121/630 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920