Protein Alignment Nepl4 and nep-6

DIOPT Version :9

• Sequence 1: NP_609019.1
• Gene: Nepl4 / 33889
• FlyBaseID: FBgn0031805
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_494537.1
• Gene: nep-6 / 184628
• WormBaseID: WBGene00017550
• Length: 726
• Species: Caenorhabditis elegans
• Alignment Length: 729
• Identity: 151/729 - (20%)
• Similarity: 277/729 - (37%)
• Gaps: 180/729 - (24%)

  Fly    22 PV-KANDPEQSCPYLGECNSTINQQHIDTLMSYVDSEKNPCEDFYAYACGKWRAKHGSHTTATMI 85
            || :|:.|...|...| |.:..:|     |:::.|...:||:|||..||||:
 Worm    74 PVTQASKPRNVCETPG-CVTLADQ-----LLNFQDPSVDPCQDFYKAACGKY------------- 119

  Fly    86 SESQI-NR--QYEDLFLQ------LLRNPSAPEYGYPMFAKVLAHYQSCIALEKPD-----LRRY 136
            ||.:: ||  |.:|:.:|      ||:|.::......:..:|   |::|..|:..:     ::..
 Worm   120 SEHEVANRRLQKKDIIIQRMIKNFLLKNETSESKSENVMRQV---YRTCEGLKNEEIFNANMKTA 181

  Fly   137 IELLDRDLL--------------ASLNSTHWMHLLAALGRYGYHGHYVQ-VEVRWYNATHHMIFL 186
            ...|.:|:.              ..||....:..:..||...:....:: .||.:......|
 Worm   182 FRELFKDIQKIGSWPAADKNWDETKLNLNEMLLNIVKLGSSNFGLFQIRPTEVPFLEVAPDM--- 243

  Fly   187 LPHNRHLNLSLTQDIYDALSQDGSSWPPLHQLQ----------EQFRSLEQNLVRLAKPHSADDT 241
             ..:..::.:..|.|:|.|.::|        ||          |.:.:||:.|.:.|..::|:
 Worm   244 -ARSPKVSANFQQIIFDILEKNG--------LQPDENVIADDVEDYITLEETLSQYAYDYNAE-- 297

  Fly   242 FRNYSLDQIRTEVPGLHWDEALRTQLG-------------RSVPGNHVFQVDDLDAIEGLVEYLN 293
              .....:::.:||.|..::.:...:.             |.|...|....|:...:|.|::  :
 Worm   298 --KVQFSKLQAQVPSLKLEKIIEEMMNPNRKKLLVTKVKPRMVAHKHSLFFDEKMNLEKLLK--S 358

  Fly   294 TVDTLLLNRYSLARFLSHLLELPHNPLATWESGQRSRGRNCIRHMRRSVYLPMN--YVYERSFYS 356
            |....|.| |.:..::.|.:    |.|:..::..:.  |||.:.:..  |||..  .|:.|:.:.
 Worm   359 TPKRTLAN-YLIFYYMDHAM----NGLSVHDNVIKK--RNCEKLVIE--YLPKASLRVFVRNHFE 414

  Fly   357 RRRHADELVIHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPPNVTEQFYWD 421
            :   .:..::..:.::.:......:|.:.: |..|..|:...|:.:|...:| .|....::...|
 Worm   415 K---GNLKIVDEMAEETKKSFIEMLQESTW-LGADSKKNAILKLEKMGKMIG-YPKEFEKKGALD 474

  Fly   422 ----------SDRRWSVGRDFYENHLNSLLYYYTLVADLESSSDQEERDIWYSFNMHTPEFPDNI 476
                      .|..:.:.:.....|:...:.:..|...::                  |..|  :
 Worm   475 KMFETLKLLPKDTLYGILKKIGRFHMEQGIEFVALETPMD------------------PVLP--V 519

  Fly   477 DATPYFYCLGNIIFVPYSYVKRPFFDANFWPALLYGDLA---NTLGHEIMHAFDTDLVDYDAQGN 538
            ..|..||...|.:.....|:..|.|||.: |.  |.::|   |.|.||..|.|||..:..|..|.
 Worm   520 LMTNAFYTDRNHLSFLVGYMDDPLFDATY-PK--YVNIALTGNILAHETSHGFDTAGIKRDENGE 581

  Fly   539 LRNF--SDQLGE--------VELYN----GAVGCLNSSAVMLNERTSDVSGSRLAMQTYGGDWLT 589
            :|::  .:.|.|        |:.||    ...|...:....|||..:|:.|..:|.:.:  :.|.
 Worm   582 VRSWMKPEDLKEYGKKTQCLVDQYNEYDDPVFGKNLNGTTTLNEMVADMIGVTVAWKVF--EKLD 644

  Fly   590 RSGN-----------GRLYFLQFAHFFCG--------DEGDQYHDSGSQRLNYALGQVPQFAEVF 635
            .|..           .:|||...|..||.        :|..:.|.:|:.|:|.....:||||..|
 Worm   645 SSKEQKVIGFENENIDKLYFRAAALDFCSLPPTTSLVEELTRVHPTGNFRVNGIFSNMPQFATAF 709

  Fly   636 RCHVGSGMTSADQC 649
            .|..||.|....:|
 Worm   710 NCPEGSPMNPKTRC 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	140/691 (20%)
		GluZincin	59..649	CDD:301352	140/689 (20%)
nep-6	NP_494537.1	M13	105..724	CDD:189000	141/692 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920