DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and nep-23

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_503004.2	Gene:	nep-23 / 178472	WormBaseID:	WBGene00013785	Length:	714	Species:	Caenorhabditis elegans

Alignment Length:	784	Identity:	155/784 - (19%)
Similarity:	268/784 - (34%)	Gaps:	251/784 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LWTALLLLGSATCGSSVPVKANDPEQSCP--------YLGECNSTINQQHIDTLMSYVDSEKNPC 61
            ||.|..|....:....:.|.....||..|        ...||.:..:|.|     :|.|...:||
Worm    40 LWEAEALSSQESMLGELKVAVTSLEQHRPGHLKKNVCQTPECITLAHQLH-----NYHDPSADPC 99

  Fly    62 EDFYAYACGKWRAKHGSHTTATMISESQINRQYEDLFLQLLRN-------------PSAPEYGYP 113
            ::||...|||   :| .|:..:.:::..:          :|||             .|..|....
Worm   100 DNFYQSVCGK---QH-EHSLKSGLAKKHL----------ILRNLIRETITNRKVTPTSKSENEMR 150

  Fly   114 MFAKVLAHYQSCIALEKPDLRRYIELLDRDLLASLNSTHWMHLLAALGRYGYHGHYVQVEVRWYN 178
            .|..:.:.||.  |....|:.:  :.| ||:...:.|.               |.:......|..
Worm   151 KFHGICSKYQR--ANSSSDIAQ--QAL-RDIFRDVQSI---------------GSWPAGSRNWNE 195

  Fly   179 ATHHMIFLLPHNRHLN--LSLTQDIYDALSQDGSSWPPLHQLQEQFRSLEQNLVRLAKPHSADDT 241
            :..::      |..||  :.|.|..:.           |.|:..::|  :|.|:      ||::.
Worm   196 SDFNL------NEMLNNLVKLGQRNFG-----------LFQISFKYR--DQLLI------SAEEH 235

  Fly   242 FRNYS------LDQIRTEVPGLHWDEALRTQLGRSVPG---------NHVFQVDDLDAIEGLV-- 289
            .||||      |:...|.  ||..|   |.||.:.:.|         || :.:|::|.::..|
Worm   236 RRNYSKLEPTILNIFETN--GLVPD---RIQLLKDLEGFASLEALLKNH-YYLDNMDKMKPAVLD 294

  Fly   290 EYLNTVDTLLLNRYSLARFLSHL---------------------------LELPHNPLATWESGQ 327
            :.:.:||.:.|.:..::....||                           |:.|...||.
Worm   295 DLVPSVDFMGLVKAMISPGKEHLMPKIELKTSVLNQTLFNDENMNLEAIILDTPKRTLAN----- 354

  Fly   328 RSRGRNCIRHMRRSVYLPMNYVYERSFYSRRRHADELVIHSVFQQL----------------QSQ 376
                           ||..|::            |..:.|.||:..                ::.
Worm   355 ---------------YLIFNFI------------DSSLDHLVFETTSQKGNTCEDKVITYLPRAS 392

  Fly   377 LELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPPNVT----EQFYWDSDRRWSVGR-----DF 432
            |.:.:::.....::||:..|..|.   ||.:..|..|.|    |......|:..::|:     ||
Worm   393 LRVFIRNYVDKENRDLITQLAEKT---RIALHTLVQNSTWLKAESKQLALDKINAMGKMIGYPDF 454

  Fly   433 YEN-----------HLNSLLYYYTLVADLESSSDQEERDIWYSFNMHTPEFPD--NIDATPYFYC 484
            :|.           :|:|...|||.:..||....:::.|.   |...||..||  ..:...|:|.
Worm   455 FEPPGTLDGMFKNLNLDSSDTYYTALNKLERYFVEQKMDY---FAEETPLDPDLRVFEMNAYYYI 516

  Fly   485 LGNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAF-----------------DTDLVD 532
            .||.:.....:...|.||:.:...:......|.:|||:.|||                 ..:|.:
Worm   517 PGNQLNFLAPFFDDPMFDSTYPDYVNIAMSGNIIGHEMGHAFGPHAILRTVRGREVWMKPEELAE 581

  Fly   533 YDAQGNLRNFSDQLGEVELYNGAVGCLNSSAVMLNERTSDVSGSRLAMQTYGGDWLTRSGN---- 593
            |:::...  .::|..|.:  :...|.:.....:::|..:|..|..::.:.:....||.:..
Worm   582 YESRAQC--LANQYSEYD--DPDFGRVFDGGKVIDELVADNIGREVSWKMFKSLDLTNATRIIGF 642

  Fly   594 -----GRLYFLQFAHFFCGDEG--------DQYHDSGSQRLNYALGQVPQFAEVFRCHVGSGMTS 645
                 .:|||...|...|....        :..|...:.|:|.....:|:||..|.|..||.|..
Worm   643 EDYDIDQLYFRVGALTHCTPHAMRDLKGSIESSHPRKAFRVNGVYANLPEFARAFNCPTGSPMNP 707

  Fly   646 ADQC 649
            ..:|
Worm   708 RKKC 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	141/722 (20%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	140/720 (19%)
nep-23	NP_503004.2	M13	96..711	CDD:189000	140/721 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920