DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and nep-17

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001254395.1	Gene:	nep-17 / 174996	WormBaseID:	WBGene00010070	Length:	1589	Species:	Caenorhabditis elegans

Alignment Length:	772	Identity:	148/772 - (19%)
Similarity:	263/772 - (34%)	Gaps:	221/772 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 QQHIDTLMSYVDSEKNPCEDFYAYACGKWRAKHGSHTTATMISESQINRQYEDLFLQLLRNPSAP 108
            |..:|.....|::..:||:|||:||||.:. :..|..||...:...:.::.||...|...|.|
Worm   870 QMAVDYYAKSVNTAIDPCDDFYSYACGNFN-QSVSFYTARAQNLVYMAQKLEDPTYQTTINSS-- 931

  Fly   109 EYGYPMFAKVLAHYQSCI----ALEKPD----LRRYIE--------LLDRD-------------- 143
                |...|....|.:|:    :.:..|    .:.||:        |:.:|
Worm   932 ----PALKKEKQLYNACLTATASSQSEDQILISKNYIQTKVDDLKTLIGQDFTLVNGGAPKLPSA 992

  Fly   144 ------------------LLASLNSTHWMHLLAALGRYGYHGHYVQVEVRWYNATHHM--IFLLP 188
                              |::.|..|:|:.     ...||. .::.....:.:.|::.  .:.:.
Worm   993 KQIGDALGYLSFEQGIDTLISPLVDTYWID-----NSKGYQ-MFIDQNTAYLSKTYYQPAAWKIE 1051

  Fly   189 HNRHLNLSLTQDIYDALSQDGSSWPP--LHQLQEQFRSLEQNLVRLAKPHSADD-TFRNYSLDQI 250
            ..::|.::|  |:....:::.:...|  ...|.......|||   :|..:|.|| |.|.:.....
Worm  1052 KPKYLKMAL--DVVTRYAREQNITLPAGASDLLSNVLDYEQN---IAVKYSTDDNTRRQFQRSWN 1111

  Fly   251 RTEVPGL--------------HWDEALRTQLGRSVPGNHVFQVDDLDAIEGL-VEYLNTVDTLLL 300
            .|:...|              |...|::.::   ...|:...|.::|.:... .:||.....||:
Worm  1112 LTKTSDLVTKYNFMDWMTYLSHAPNAVKAKI---TDANYQVSVMEVDRLTHFSADYLQQSPELLV 1173

  Fly   301 NRYSLARFLSHLLELP--------------------------HNPLATWE---SGQ--RSRGRNC 334
            |...:...|.:...:|                          |.|...::   :|.  .|...|.
Worm  1174 NLLFVRLLLGNAQYIPSYASAFRGMTDESIFLGLSRRKTIPNHIPPPNFDLEANGPACASVANNL 1238

  Fly   335 IRHMRRSVYLPMNYVYERSFYSRRRHADELV--IHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQ 397
            ::.....|::...|...:...:.|:.|..::  :.|.||.:..||:.        ::.|..:...
Worm  1239 MQFANGRVFVDYMYPTAQDVTNIRKSAGGIIKNVISSFQGMIDQLDW--------MAPDTKQKAY 1295

  Fly   398 AKVHQMRINVGNLPPNVTEQFYWDSDRRWSVGRDFYENHLNSLL--YYYTLV-ADLESSSDQEER 459
            ||..|::.|:. .|                   |:.:|  ::||  ||.||| ||.::..|..::
Worm  1296 AKTVQIQQNIA-FP-------------------DWIKN--DTLLGNYYSTLVIADSDNFYDIYDK 1338

  Fly   460 ----DIWYSFNMHTPEFPDNID-------ATPYFYCLGNIIFVPYSYVKRPFFDANFWPALLYGD 513
                :|:..:|.......|..|       ...::....|.|..|...:..|:|:.|:.|::.||.
Worm  1339 LIKFNIFVQYNQLNAAQTDRTDFLGQPGTVNAWYQPELNSITFPAGILVPPYFNPNWPPSINYGG 1403

  Fly   514 LANTLGHEIMHAFDTDLVDYDAQGNLRNFSDQLGEVELYNGAVGCLNSSAVMLN----------- 567
            :....|||:.|.||...|.:...|||..:.|.       |...|..|.|..::|
Worm  1404 MGLVAGHELTHGFDDQGVQWGPTGNLARWMDD-------NSMAGFKNMSQCVINEYSGFCPLNAT 1461

  Fly   568 --------------ERTSDVSGSRLAMQTY-------GGD------WLTRSGNGRLYFLQFAHFF 605
                          |..:|..|...|...|       |.|      ...:..:.:|:|:.||..:
Worm  1462 NYSPNCVKGPQTQGENIADNGGVHAAFNAYKTHQSLDGPDPRLPDRLFGQFTHDQLFFMSFAQVW 1526

  Fly   606 C---GDEGDQY-------HDSGSQRLNYALGQVPQFAEVFRCHVGSGMTSADQCPFW 652
            |   ..:...|       |.....|:...:...|.|...|.|.:||.......|..|
Worm  1527 CEVRRTDDALYTQIMVDPHSPSMYRVYGTIQNFPAFQTAFNCPLGSKSAPEQHCEVW 1583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	144/754 (19%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	143/752 (19%)
nep-17	NP_001254395.1	PepO	108..833	CDD:226118
		M13	112..830	CDD:189000
		PepO	880..1583	CDD:226118	145/760 (19%)
		M13	884..1581	CDD:189000	143/754 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020