Protein Alignment Nepl4 and nep-3

DIOPT Version :9

• Sequence 1: NP_609019.1
• Gene: Nepl4 / 33889
• FlyBaseID: FBgn0031805
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_494679.2
• Gene: nep-3 / 173730
• WormBaseID: WBGene00016778
• Length: 634
• Species: Caenorhabditis elegans
• Alignment Length: 736
• Identity: 152/736 - (20%)
• Similarity: 255/736 - (34%)
• Gaps: 229/736 - (31%)

  Fly     9 LLLLGSATCGSSVPVKAND---------PEQSCPYLGECNSTINQQHIDTLMSYVDSEKNPCEDF 64
            :|||.:...|..|....::         |:..| ...||.:.::|     |:::.|...:|||:|
 Worm    30 VLLLEAGKIGGEVSENCSNHSTSSASPKPKPMC-LTPECITLVHQ-----LLNFQDPSVDPCENF 88

  Fly    65 YAYACGKWRAKH---GSHTTATMISESQINRQYEDLFLQLLRNPSAPEYGYPMFAKVLAHYQSCI 126
            |..||||:...:   ||.|.           |.:.:..:|:|
 Worm    89 YQAACGKYNEHNVIDGSRTA-----------QKQQIVKRLIR----------------------- 119

  Fly   127 ALEKPDLRRYIELLDRDLLASLNSTHWMHLL----------AALGRYGYHGHYVQVEVRWYNATH 181
                       :.|.::..::..|.:.|.||          ..||
 Worm   120 -----------DFLHKNQSSTSKSENSMKLLYEKCKEAKTIKVLG-------------------- 153

  Fly   182 HMIFLLPHNRHLNLSLTQDIYDALSQDGSSWPPLHQ--------LQEQFRSLEQNLVRLAKPH-- 236
                        |.:|.|:|:..:.:.| |||.|.:        |.|...|    |:||...:
 Worm   154 ------------NQNLLQEIFMNIQKIG-SWPVLDENWDGKKFNLNEMLLS----LIRLGVSNFG 201

  Fly   237 -----SADDTF------RNY----SLDQIRTEVPGLHWDEALRTQLGRSVPGNHVFQVDDLDAIE 286
                 .:.|.|      ||:    :|..|.::|           .||.....|.....:||...|
 Worm   202 FFEIIISSDAFVEIKPARNFPTRENLSDIISKV-----------FLGNGFQPNITAIENDLREYE 255

  Fly   287 GLVEYLNTVDTLLL---NRYSLARFL------SHLLELPHNPLATWESGQRSRGRNCIRHMRRSV 342
            .|...|.:::.|:.   || ||..:|      |.:||....|....|.....
 Worm   256 NLQRELKSLERLIQTTPNR-SLVNYLIFNYLKSVMLEYKRLPEEQCEGVVID------------- 306

  Fly   343 YLP--MNYVYERSFYSRRRHADELVIHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRI 405
            :||  ...|:.::|..:.   :...:..:.:.::......:|.:.: |:::..|....||..::.
 Worm   307 FLPRASTRVFVQNFLDKE---NRKYVAGMIEDVKMGFIDMIQESTW-LNEESKKVAVQKVKNIKS 367

  Fly   406 NVGN----LPPNVTEQFYWDSDRRWSVGRDFYENHLNSLLYYYTLVADLESSSDQEERDIWYSFN 466
            .:|.    .||.             ::.|.|.:.::.....|:|:|..::..::::..:...|..
 Worm   368 MIGYPDFFEPPG-------------TLDRSFKDLNIEQTDSYHTIVRKIQKFTNEQCMEFVASEI 419

  Fly   467 MHTPEFPDNIDATPYFYCLGNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLV 531
            ...|..|  |.....||...|.:.:....:..|.||..|...:....:.|.|.|||.||||...:
 Worm   420 PLDPRQP--ILHANAFYQNTNFLAILAPVLDDPIFDTTFPRYVNLAVIGNVLAHEIGHAFDHTGI 482

  Fly   532 DYDAQGNLRNFSDQLGEVELYNGAVGC----------------LNSSAVMLNERTSDVSGSRLAM 580
            :||..|..|.:... .:.|.|...:.|                ||.|.. |:|.::|..|...|.
 Worm   483 NYDDAGQQRIWLTP-EDSEEYGKRLRCLLRQHDEYDDPDFGRNLNGSKT-LHEISADRFGVEAAW 545

  Fly   581 QTYGGDWLTRSGN---------GRLYFLQFAHFFC--GDEGD-QY-----HDSGSQRLNYALGQV 628
            :|:....|:....         .:|||...|..:|  .|..| ||     |.:.:.|:|.....:
 Worm   546 RTFKKLDLSNESEIVGFQNFNIDQLYFRTAALIWCRQRDTTDLQYALQREHPTNNFRVNGIYANM 610

  Fly   629 PQFAEVFRCHVGSGMTSADQC 649
            |||||.|.|.:||.|....:|
 Worm   611 PQFAETFNCPLGSPMNPKKKC 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	139/677 (21%)
		GluZincin	59..649	CDD:301352	139/675 (21%)
nep-3	NP_494679.2	M13	82..631	CDD:189000	139/676 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920