DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and nep-11

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_494538.1	Gene:	nep-11 / 173685	WormBaseID:	WBGene00017557	Length:	848	Species:	Caenorhabditis elegans

Alignment Length:	751	Identity:	159/751 - (21%)
Similarity:	270/751 - (35%)	Gaps:	225/751 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 MSYVDSEKNPCEDFYAYACGKWRAKH-------GSHTTA----------------TMISESQ-IN 91
            ::.:::..:||:||:.:|||:|..:|       |..|.|                .:::||: ||
Worm   174 LNAMNTSVDPCDDFFEFACGQWNDQHPIPDDMYGFGTFAYAREQVRQQLRVLLEQEVVTESESIN 238

  Fly    92 ------------RQYEDL----------------------------FLQLLRNPSAPEYGYPMFA 116
                        .|.::|                            |..||.| |..:||..:|
Worm   239 MARATYRSCMNKTQLDELMTGPLFETLTELGEWPLLQENWDKTKFNFTSLLVN-SRRDYGVDVF- 301

  Fly   117 KVLAHYQSCIALEKPDLRRYIELLDRDLLASLNSTHWMHLLAALGRYGYHGHYVQVEVRWYNATH 181
                 :|..|..:..:..|....:|:..|             |||| |...:|:       |.|.
Worm   302 -----FQLYIYADSKNTSRNTLFIDQSTL-------------ALGR-GTRDYYL-------NTTL 340

  Fly   182 HMIFLLPHNRHLNLSLTQDIYDALSQDGSSWPPLHQLQEQFRSLEQNLVRLAKPHSADDTFRN-- 244
            ....:..:.::|     :.|...|..||:......::......:....:.|||...|:|..||
Worm   341 FSSHMTAYRKYL-----RQIAHLLKTDGNLTRSESEMNADIEKIIDFEIELAKIIVAEDERRNNT 400

  Fly   245 --YSLDQIR---TEVPGLHWDEALRTQLGRSVPGN--HVFQ------VDDLDAIEGLVEYLNTVD 296
              |:..||:   ..:|.:.|....::    ..|.:  |:|.      :.:::.::.:.|.:...|
Worm   401 RLYNKRQIQDLYNLLPQVDWVPFFQS----IAPSDLTHLFHNETEIIICEIEYLQHVSELIEKTD 461

  Fly   297 TLLLNRYSL-------ARFLSHLLE-LPHNPLATWESGQRS--RGRNCIRHMRRSVYLPMNYVYE 351
            ..||..|.|       .|:|....| :..:.|......|:|  |.::|.:  ..|..||:
Worm   462 VGLLTNYVLWRVVQSNVRYLDERFEDIKQDFLKVMTGQQQSPPRWKDCAQ--VPSTVLPL----- 519

  Fly   352 RSFYSRRRHADELVIHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQ-----------AKVHQMRI 405
                    .|..:.:.:.||:......||:..:..|...|||:...           .|.:.|..
Worm   520 --------AAGAIYVQAHFQESDKHEALRMIMHLRNSFADLVRQNDWMDEETKAVAIEKANSMIN 576

  Fly   406 NVG-----NLPPNVTEQFYW----DSDRRWSVGRDFYENHLNSLLYYYTLVADLESSSDQEERDI 461
            |:|     |..|.:.:|:..    |||                 .|||.:...:.....:|.:.:
Worm   577 NIGYPDVTNDLPKLDKQYLGLSISDSD-----------------TYYYIMKKSVVWMQSREFQKL 624

  Fly   462 WYSFNMHTPEFPDNIDATP-----YFYCLGNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHE 521
            ...|:.|  ||    |.:|     ::....|.|..|...::.|||...|..|:.||.:...:|||
Worm   625 TKPFDKH--EF----DISPAVVNAFYSPEKNAITFPAGILQPPFFSGTFPKAVNYGAIGAVIGHE 683

  Fly   522 IMHAFDTDLVDYDAQGNLRNF--SDQLGE--------VELY-NGAVGCLN---SSAVMLNERTSD 572
            |.|.||.....||..|||.|:  ...|..        ||.| |..|...|   :..:...|..:|
Worm   684 ITHGFDDQGSQYDKDGNLHNWWSESSLNSFDTRRRCIVEQYGNYTVPKTNFRVNGKLTQGENIAD 748

  Fly   573 VSGSRLAMQTYGGDWLTRSG------------NGRLYFLQFAHFFCGDEGD---------QYHDS 616
            ..|.:.|.|.| ..::|.:|            |.:::|:.:|||:||.:.:         ..|..
Worm   749 NGGVKEAFQAY-QKYVTENGEEPRLPGLQQYTNEQIFFVSYAHFWCGKKKEAAAMQQVLTDEHSP 812

  Fly   617 GSQRLNYALGQVPQFAEVFRCHVGSGMTSADQCPFW 652
            ...|:...|..:..||:|::|...:.:....:|..|
Worm   813 EVFRVIGVLSNMQAFADVYKCPRNAPVNPDHKCIVW 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	157/740 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	157/738 (21%)
nep-11	NP_494538.1	PepO	174..848	CDD:226118	158/749 (21%)
nep-11	NP_494538.1	M13	181..845	CDD:189000	157/739 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020