Protein Alignment Nepl4 and nep-13

DIOPT Version :10

• Sequence 1: NP_609019.1
• Gene: Nepl4 / 33889
• FlyBaseID: FBgn0031805
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_001342017.1
• Gene: nep-13 / 173672
• WormBaseID: WBGene00018196
• Length: 732
• Species: Caenorhabditis elegans
• Alignment Length: 695
• Identity: 136/695 - (19%)
• Similarity: 266/695 - (38%)
• Gaps: 154/695 - (22%)

  Fly    49 TLMSYVDSEKNPCEDFYAYACGKWRAKHGSHTTATMISESQINRQYEDLFLQ-LLRNPSAPEYGY 112
            ||:::.::..:||||||.|:||:::    .||....|..::.:.....|..| :|:|.|......
 Worm    95 TLLNWQNTNIDPCEDFYEYSCGRYQ----EHTLNDGIRANEKDTIVMKLIRQFVLKNQSTTSNSE 155

  Fly   113 PMFAKVLAHYQSC-IALEKPDLRRYIELLDRDLLASL-------------NSTHW---------- 153
               ..::..|:.| :.....:..:..|::.|::..::             ||:|:
 Worm   156 ---NALMLLYEKCSLRYRMENRHQETEVIQREVFENIRKIGSWPIADKNWNSSHFNLNNMLSNMA 217

  Fly   154 -MHLLAALGRYGYHGHYVQVEVRWYNATHHMIFLLPHNRHLNLSLTQD-----IYDALSQDGSSW 212
             :|:|.    :|.....| :|:...|.|...:.:.|  ..|..|:.|:     |.|.||.:|.:
 Worm   218 SIHMLP----FGLFETRV-IELYPMNTTAKQLVIRP--TKLKFSIPQEELVRAIRDLLSVNGIT- 274

  Fly   213 PPLHQLQEQFRSLEQNLVRLAKPHSADDTFRNYSLDQIRTEVPGLHWD----EALRTQLGRSVPG 273
                           ::::..|    :|...:::||:   |:..:|.|    .|..::|.::||
 Worm   275 ---------------SIMKKVK----EDVAESFALDK---EIGNIHIDPQPKPATLSELQKAVP- 316

  Fly   274 NHVFQVDDLDAIEGLVEYLN-------TVDTLLLN-RYSL----------------ARFLSHLLE 314
                   |:|....:..|||       ::.|.:.: |:.|                .|.|::.|.
 Worm   317 -------DIDFERIIKSYLNPKTGNWSSLRTKIFSARFELFFGKNNNLSSIIARTKPRILANYLF 374

  Fly   315 LPHNPLATW----ESGQRSRGRNCIRHMRRSVYLPMNYVYERSFYSRRRHADELVIHSVFQQLQS 375
            |.:...|.:    .:...|....|...:..|:......|:.|:.:.:    :.:.:.|...::..
 Worm   375 LKYIEYAYFFFFDNTKVFSDDDFCTEVVTTSLPRASLRVFVRNHFKK----ENMAVASEIVEVVK 435

  Fly   376 QLELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPPNVTEQFYWDSDRRWSVGRDFYENHLNSL 440
            ...:.:.:|:..|.....:|...||.:|:..:|     .||::    :|..::...|....|:..
 Worm   436 TAYVEIINNSTWLHNSTRESAIEKVVKMKKVIG-----YTEEY----ERTGALDEMFETLQLSRS 491

  Fly   441 LYYYTLVADLESSSDQEERDIWYSFNMHTPEFPDNIDATPYFYCLGNIIFVPYSYVKRPFFDANF 505
            ..::.|:..:.....::..|...|.::..|..| .:.|..:::...|::.|...::.:|.||..:
 Worm   492 DSFFVLMTKVNRFKIEQLMDFVSSDSLLNPIEP-LVMANAFYFPTKNLLNVLVPFLDKPLFDFKY 555

  Fly   506 WPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNLRNFSDQLGEVELYNGAVGCL----------- 559
            ...:....:...|.|||.||||.:....|..|..|::..: .:.|.|:....|.
 Worm   556 PRYVAMAGVGRVLAHEIGHAFDINGRQTDEIGRTRDWWTR-EDTEEYDRRSECFAEQFTNFKDPS 619

  Fly   560 ----NSSAVMLNERTSDVSGSRLAMQTYGGDWLTRSGN---------GRLYFLQFAHFFCGDE-- 609
                .:...:|.|..:|..|...:...:....||....         |:|||...|..||...
 Worm   620 FKGKQNGTEVLAEIIADALGMEASWIAFKKINLTEEQGLIQFEDHDFGKLYFQVAALDFCAPSRI 684

  Fly   610 ----GDQY-HDSGSQRLNYALGQVPQFAEVFRCHVGSGMTSADQC 649
                .||. |.:...|:|.|......||:.::|.|||.|....:|
 Worm   685 EERYSDQLSHPTNKFRINGAFSNSRAFADTYKCPVGSKMNPVQRC 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	GluZincin	59..649	CDD:472708	133/683 (19%)
nep-13	NP_001342017.1	M13	104..729	CDD:341056	133/684 (19%)