DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl4 and mme

DIOPT Version :9

Sequence 1:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_031758820.1	Gene:	mme / 101734885	XenbaseID:	XB-GENE-1011098	Length:	746	Species:	Xenopus tropicalis

Alignment Length:	790	Identity:	171/790 - (21%)
Similarity:	280/790 - (35%)	Gaps:	228/790 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLGSATCGSSVPVKANDPEQSCPYLGECNSTINQQHIDT---LMSYVDSEKNPCEDFYAYACGK 71
            ::|..||        :||        |.|.|   |..|.|   :::.:|:..:||.|||.||||.
Frog    38 MILAYAT--------SND--------GICTS---QACISTAARIIANMDAATDPCNDFYQYACGG 83

  Fly    72 WRAKHGSHTTATMISESQINR-QYEDLFLQLLRNPSAPEYGYPMFAKVLAHYQSCI-----ALEK 130
            |..|:.......:.:...|.| ..|.:....|...||.:  .|...||...|:|||     .|.|
Frog    84 WLKKNRIPDNNIVSNTFDILRTDIEVVLKDALEKESADD--IPAIKKVKTFYKSCIDETIKNLRK 146

  Fly   131 --PDLRRYIELLDRDLLASLNSTHWMHLLAA-------LGRYGYHG---HYVQVEVRWYNATHHM 183
              |.::....|.|..:......|.:..:.:|       :.:||..|   .||..::     |:..
Frog   147 GGPLIKTLPALYDWPIAVDNWETRYGLVWSAQESIAGFITKYGQSGLINVYVSEDL-----TNSS 206

  Fly   184 IFLLPHNRHLNLSL-TQDIYDALSQDGSSWPPLHQLQEQFRSL------EQNLV----------- 230
            .::| |.....|.| ::|.||.   .|:|........||..|:      |:||.
Frog   207 TYIL-HIDQPGLGLPSKDYYDC---KGTSEIACLAYMEQMVSVAMLIRKERNLTINEDKILSEME 267

  Fly   231 -------RLAKPHSAD-------DTFRNYSLDQIRTEVP------GLHWDEALRTQL---GRSVP 272
                   .:||..:::       |.::..:|..|....|      .::|.:.:...:   |.|:.
Frog   268 KVFKLEREIAKAEASEEIRENLNDIYKKMTLSGIAKTYPLKMNDQNINWLKLINAIISPGGVSIE 332

  Fly   273 GNHVFQVDDLDAIEGLVEYLNTVDTLLLNRYSLARF-LSHLLELP--------HNPLATW-ESGQ 327
            .|....:...|.::.| .:||......|..|...|: ||.:.:|.        |...|.: .:.:
Frog   333 ENEQVALICSDYLKKL-RFLNKYKARELQNYLGWRYILSAINDLSLEYKNTGIHLKKALYGNAAE 396

  Fly   328 RSRGRNCIRHMRRSVYLPMNYVYERSFYSRRRHADELVIHSVFQQLQSQLELRVQHNAFNLSQDL 392
            .|..:.|:.::..::...:..:|                      |:..|...::|...   :|.
Frog   397 GSDWQTCVTYLNDNMEDAIGRLY----------------------LKETLSADIEHVKV---KDK 436

  Fly   393 VKSLQAKVHQMRINVGNLPPNVTEQFYW-DSDRRWSVGR-----------------DFYENHLNS 439
            ||.:.|::.:..:       .:.|:..| |.|.:....|                 ||..|...|
Frog   437 VKEIIAEIRRAFL-------EMLEEMDWMDEDTKKRAARKVASINERIAFSEDIMDDFKLNEGYS 494

  Fly   440 LLYYYTLVADLESSSDQ--EERDIWYSF---------------NMHTPEFPDNIDATPYFYCLG- 486
                     :||...|:  |.:..:..|               |...|. |.:::|   ||.|.
Frog   495 ---------ELEFRVDELFENKQKYIEFVQKKMTSRLRKQVNKNEWVPG-PAHVNA---FYSLTY 546

  Fly   487 NIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNLRN---------- 541
            |.|..|...::.|||.::...||.||.:...:||||.|.||....::|..|||.|
Frog   547 NEIVFPAGILQTPFFSSSQPSALNYGGIGMIIGHEITHGFDNRGCNFDEHGNLVNWWTNASMMNF 611

  Fly   542 ------FSDQLGEVELYNGAVGCLNSSAVMLNERTSDVSGSRLAMQTY--------------GGD 586
                  |.:|.|... ::.|.|...:....|.|..||..|.|.|.:.:              |.|
Frog   612 SNLSQCFVNQYGNYS-WDEAGGQYLNGISTLGENISDNGGIRGAYRAFKNYVKSHKEDDLLPGID 675

  Fly   587 WLTRSGNGRLYFLQFAHFFCGDEGDQY---------HDSGSQRLNYALGQVPQFAEVFRCHVGSG 642
                ..:.:|:|:.|...:||....:|         |..|..|:...|...|:|::.|.|...:.
Frog   676 ----LDSDQLFFISFGQIWCGMHRPEYAATLIKTGSHTPGIFRVIGTLQNSPEFSKAFSCCNNAY 736

  Fly   643 MTSADQCPFW 652
            |..|.:|..|
Frog   737 MNPAVKCKLW 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	156/735 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	157/733 (21%)
mme	XP_031758820.1	M13	71..744	CDD:341056	157/734 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020