Protein Alignment Nepl4 and ecel1

DIOPT Version :10

• Sequence 1: NP_609019.1
• Gene: Nepl4 / 33889
• FlyBaseID: FBgn0031805
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_012818808.2
• Gene: ecel1 / 100496473
• XenbaseID: XB-GENE-989944
• Length: 764
• Species: Xenopus tropicalis
• Alignment Length: 698
• Identity: 147/698 - (21%)
• Similarity: 263/698 - (37%)
• Gaps: 141/698 - (20%)

  Fly    54 VDSEKNPCEDFYAYACGKWRAKHGSHTTATMISESQ--------INRQYEDLFLQLLRNPSAPEY 110
            :|...:||.|||::|||.|..:||       |.|.:        |..|.|:....||..|...::
 Frog   109 IDPTISPCTDFYSFACGGWLRRHG-------IPEDKLIYGTIAAIGEQNEEKLEHLLLQPVRRKH 166

  Fly   111 GYPMFAKVLAHYQSCIALEKPDLRRYIELLDRDLLASLNS-----------THW--MHLLAALGR 162
            ......||...::||:     ::|....|..|.:|..:..           |.|  ..||
 Frog   167 KGSAERKVKEFFKSCL-----NMRDIDRLGARPMLQVIEDCGGWDLPEDPRTQWDFNELL----- 221

  Fly   163 YGYHGHY-------VQVEVRWYNATHHMI------FLLPHNRHLNLSLTQD--------IYDALS 206
            |...|.|       :.|.:...|::.::|      ..||..   .|.|.||        .|....
 Frog   222 YKTQGVYSTAVFFSMTVSLDDKNSSRYIIRIDQDGLTLPER---TLYLGQDEESIKVLEAYKVFM 283

  Fly   207 QDGSSWPPLHQLQ---EQFRSLEQNLVRLAKPHSADDTFRNYS-------LDQIRTEVPGLHWDE 261
            |...|...:..:|   |:...|||:|..:. ....||..|:.|       |.|::...|.|:|..
 Frog   284 QTILSLLGVENVQKKAEEILHLEQHLSNIT-ISEFDDMRRDISTMYNKVTLAQLQQITPHLNWKN 347

  Fly   262 ALRTQLGRSVPGNHVFQVDDLDAIEGLVEYLNTVDTLLLNRYSLARFLSHLLELPHNPL--ATWE 324
            .|......:.|.:....|...|.::.:.|.:.:....:|:.|.|.|.:..|.|....|.  |..|
 Frog   348 LLNRIFHTNFPEDEEVVVLATDYMQKVSEMIRSTPASVLHNYMLWRIVVVLSEHLSTPFRDAIHE 412

  Fly   325 SGQRSRG--------RNCIRHMRRSVYLPMNYVYERSFYSRRRHADELVIHSVFQQLQSQLELRV 381
            ..:...|        :.|:....:...:.:..::...::|....|.   :..:.:.::..|:.|:
 Frog   413 LSKEMEGSEKQAELTKVCLTQANKHFGMALGALFVEEYFSSSSKAK---VQQLVENIKHILDYRL 474

  Fly   382 QHNAFNLSQDLVKSLQAKVHQMRINVGNLPPNVTEQFYWDSDRRWSVG-RDFYENHLNSLLYYYT 445
            :...: :..:..::.:.|:..|.:.:| .|..:.:....|.:..:.|. :.:::|.|||:  .|:
 Frog   475 EELDW-MDTETKQAAREKLKHMMVMIG-YPDVLLQPESMDKEYEFEVNEKTYFKNILNSI--RYS 535

  Fly   446 LVADLESSSDQEERDIWYSFNMHTPEFPDNIDATPYFYCLGNIIFVPYSYVKRPFFDANFWPALL 510
            :...:.....:.::..|.     .|  |..::|  |:....|.:..|...::...:|.:|..:|.
 Frog   536 IKMAVRRIRQEVDKSAWL-----LP--PQALNA--YYLPNKNQMVFPAGILQPTLYDPDFPQSLN 591

  Fly   511 YGDLANTLGHEIMHAFDTDLVDYDAQGN------LRNFSDQLGEVE----------LYNGAVGCL 559
            ||.:...:|||:.|.:|.....|||.||      ..::|..|.:.|          :||..|
 Frog   592 YGGIGTIIGHELTHGYDDWGGQYDANGNPIQWWTEDSYSKFLKKAECIVDLYENFTVYNQRV--- 653

  Fly   560 NSSAVMLNERTSDVSGSRLAMQTYGGDWLTRSG-----------NGRLYFLQFAHFFCGDEGDQ- 612
             :....|.|..:|:.|.:||...| ..|:..:|           :.:|:|:.||..:|.....|
 Frog   654 -NGRTTLGENIADLGGLKLAYYAY-QKWVRDNGPERPLPRLKYTHDQLFFIAFAQNWCIKRRSQS 716

  Fly   613 --------YHDSGSQRLNYALGQVPQFAEVFRCHVGSGMTSADQCPFW 652
                    .|.....|:..::.|..:|..||.|...|.|....:|..|
 Frog   717 IYLQVLTDKHAPEHYRVMGSVSQFEEFGRVFHCPRNSPMNPVHKCSVW 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	GluZincin	59..649	CDD:472708	144/688 (21%)
ecel1	XP_012818808.2	M13	113..762	CDD:341056	144/690 (21%)