Protein Alignment Nepl4 and phex

DIOPT Version :10

• Sequence 1: NP_609019.1
• Gene: Nepl4 / 33889
• FlyBaseID: FBgn0031805
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_004911718.1
• Gene: phex / 100496470
• XenbaseID: XB-GENE-1012247
• Length: 750
• Species: Xenopus tropicalis
• Alignment Length: 729
• Identity: 155/729 - (21%)
• Similarity: 266/729 - (36%)
• Gaps: 169/729 - (23%)

  Fly    49 TLMSYVDSEKNPCEDFYAYACGKWRAKHGSHTTATMISESQIN------------RQYEDLFLQ- 100
            ::.|.::...:||:||:.||||.|            |.|:.|.            |...||.|:
 Frog    66 SIRSKMNLSVDPCDDFFQYACGGW------------IEENPIPDDMSNYGIYPWLRTNVDLKLKA 118

  Fly   101 LLRNPSAPEYGYPMFAKVLAHYQSCI---ALEKPDLRRYIELLDRDLLASLNSTHWMHLLAALGR 162
            ||..|.:.........||...|.||:   .:|:.|::..:::|.:.      |..|..|.:.:|.
 Frog   119 LLEKPISKRRDSEAIQKVKTFYISCMNETQIEEDDIKPILKILKQP------SLRWPVLESNIGS 177

  Fly   163 YGYHGH------------------------YVQVEVRWYN-----ATHHMIFLLPHNRHL-NLSL 197
            .|....                        ||.::.:..|     .....:.||.|..:| |.::
 Frog   178 DGKWSERKFSFLQTVADLRRLYSTSVFLRVYVAIDDKVSNNFILKLDQASLSLLSHEDYLDNSTI 242

  Fly   198 TQDIYDALSQD--------GSSWPPLHQLQEQFRSLEQNLVRLAKP---HSADDTFRNYSLDQIR 251
            .:...|||.:.        |::........:....||..|.::..|   .:::..:...::.::.
 Frog   243 AKKYRDALLEFMVDVAVLLGANKTRAETDMKALIELETKLAQITVPQENRTSEMMYNKMNISELS 307

  Fly   252 TEVPGLHWDEALRTQLGRSV-PGNHVFQVDDLDAIEGLV----------------EYLNTVDTLL 299
            ..:|...|...|:..:..:: |     ::.::|..|.::                |...|:...|
 Frog   308 AMIPQFDWLSYLKNIIDFNIYP-----ELKNIDLSENVIVRVPQHFKDLFNIIESEEKRTLANYL 367

  Fly   300 LNR--YS-----LARFLSHLLELPHNPLATWESGQRSRGRNCIRHMRRSVYLPMNYVY-ERSFYS 356
            :.|  ||     ..||....||.....|.|  :....|...|:.::..|:..|:..:: :..|..
 Frog   368 IWRLVYSRIPNLSRRFQYRQLEFARILLGT--NSLAGRWDRCVNYVENSIPYPVGKLFVDAHFQE 430

  Fly   357 RRRHADELVIHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPPNVTEQFYWD 421
            .::...|.::..:.......||   :.|.:..::..:|:.|..|..| ..|| .|..:....|.:
 Frog   431 DKKDMMEELVDGIRWAFIDMLE---KENDWMDAETKIKAKQKAVTVM-AKVG-YPEFLFNDTYLN 490

  Fly   422 SD---RRWSVGRDFYENHLNSLLYYYTLVADLESSSDQEERDIWYSFNMHTPEFPDNIDATPYFY 483
            .|   .::|.. |::.|.|.:|.:.        |.||    ..|...|:...|:..|......||
 Frog   491 EDIKMLKFSES-DYFGNVLQTLHFI--------SQSD----FYWLRRNVPKKEWFTNPTTVNAFY 542

  Fly   484 CLG-NIIFVPYSYVKRPFFDANFWP-ALLYGDLANTLGHEIMHAFDTDLVDYDAQGNL------- 539
            ... |.|..|...:::|||....:| :|.||.:...:|||..|.||.:...||.:|||
 Frog   543 SASTNQIRFPAGELQKPFFWGVQYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKEGNLFSWWTSE 607

  Fly   540 --RNFSDQ-LGEVELYNG----AVGCLNSSAVMLNERTSDVSGSRLAMQTYGGDWL--TRSG--- 592
              ..|.:: |..||.||.    ..|........|:|..:|..|.|.:.:.| ..|:  .|.|
 Frog   608 SEERFKNKTLCMVEQYNNYYWKQAGLHVKGMKTLSENIADNGGIRESFRAY-RKWIEDLRKGKEE 671

  Fly   593 ---------NGRLYFLQFAHFFCG-----DEGDQ----YHDSGSQRLNYALGQVPQFAEVFRCHV 639
                     |.:|:|:.:||..|.     ...||    .|.....|:..|:....:|.:.|.|..
 Frog   672 MLLPGLDLNNNQLFFISYAHVRCNSFRIESARDQIMNGVHSPPQFRVIGAMSNFEEFHKAFSCPK 736

  Fly   640 GSGMT-SADQCPFW 652
            .|.|. .|:.|..|
 Frog   737 DSKMNRGANSCRVW 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl4	NP_609019.1	GluZincin	59..649	CDD:472708	152/714 (21%)
phex	XP_004911718.1	M13	75..741	CDD:341056	150/709 (21%)