DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9500 and FGG

DIOPT Version :9

Sequence 1:	NP_609018.3	Gene:	CG9500 / 33888	FlyBaseID:	FBgn0031804	Length:	292	Species:	Drosophila melanogaster
Sequence 2:	NP_068656.2	Gene:	FGG / 2266	HGNCID:	3694	Length:	453	Species:	Homo sapiens

Alignment Length:	363	Identity:	99/363 - (27%)
Similarity:	150/363 - (41%)	Gaps:	92/363 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LSFYSTEA-MDSESFQNDT-AIRNK-PELKSLYKLVLALLEENQS------NAST-------ENI 61
            ||.|.|:. .|.:|.::.. .:.|| .|:|.|.|.:......::|      :|:|       |.|
Human    55 LSTYQTKVDKDLQSLEDILHQVENKTSEVKQLIKAIQLTYNPDESSKPNMIDAATLKSRKMLEEI 119

  Fly    62 QKSSSDLNTTGLSGRYPSQ--------------------------CPTYPPAH------------ 88
            .|..:.:.|...|.||..:                          |......|
Human   120 MKYEASILTHDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIAN 184

  Fly    89 ------GIYTVQVL-GLKPFQVSCDAEIAGTGWTVMARRTSNKLNFFRSWAEYKNGFGQLD---- 142
                  |:|.::.| ..:.|.|.|:.:.:|.||||..:|....::|.::|.:||.|||.|.
Human   185 KGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSVDFKKNWIQYKEGFGHLSPTGT 249

  Fly   143 GDFFIGLDKLHAITKSQ--PHELYIHLEDFEGQTRYAHYDEIFIESENKFYAMTKLGEFTGDAGD 205
            .:|::|.:|:|.|:...  |:.|.:.|||:.|:|..|.|....:..|...|.:|......|||||
Human   250 TEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGD 314

  Fly   206 SM---------------IHNRNQNFSTFDRDNDGWHKNCAEEYVGAWWHLNCTYSNLFGIYVKGD 255
            :.               .||..| |||:|.|||.:..||||:....||...|...:|.|:|.:|
Human   315 AFDGFDFGDDPSDKFFTSHNGMQ-FSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQG- 377

  Fly   256 EGQYFQW-------KGIVWHSWRTESYSYKVMQMMVRP 286
             |.|.:.       .||:|.:|:|..||.|...|.:.|
Human   378 -GTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIP 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9500	NP_609018.3	FReD	76..287	CDD:238040	79/284 (28%)
FGG	NP_068656.2	Fib_alpha	31..172	CDD:285864	23/116 (20%)
		FReD	175..414	CDD:294064	74/241 (31%)
		Gamma-chain polymerization, binding amino end of another fibrin alpha chain	400..422		6/15 (40%)
		Platelet aggregation and Staphylococcus clumping	423..437
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..453
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810