DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9500 and FGA

DIOPT Version :9

Sequence 1:	NP_609018.3	Gene:	CG9500 / 33888	FlyBaseID:	FBgn0031804	Length:	292	Species:	Drosophila melanogaster
Sequence 2:	NP_000499.1	Gene:	FGA / 2243	HGNCID:	3661	Length:	866	Species:	Homo sapiens

Alignment Length:	303	Identity:	103/303 - (33%)
Similarity:	149/303 - (49%)	Gaps:	47/303 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SFYSTEAMDSESF-QNDTAIRNKPELKSLYKLVLALLEENQSNASTENIQKSSSDLNTTGLSGRY 77
            |.||.:...|.|: :.|:...:|.     ||:.    :|..|.|..|....:...    ....|.
Human   577 SSYSKQFTSSTSYNRGDSTFESKS-----YKMA----DEAGSEADHEGTHSTKRG----HAKSRP 628

  Fly    78 PSQC----PTYPPA--HGIYTVQVLG-LKPFQVSCDAEIAGTGWTVMARRTSNKLNFFRSWAEYK 135
            ...|    .|:|..  .||:.:::.| .|.|.|.||.|.:..||.::.:|....|||.|:|.:||
Human   629 VRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYK 693

  Fly   136 NGFGQL----DGDFFIGLDKLHAITKSQPHELYIHLEDFEGQTRYAHYDEIFIESENKFYAMTKL 196
            .|||.|    :|:|::|.|.||.:|: :...|.:.|||:.|...||.| ...:.||.:.||: ::
Human   694 RGFGSLNDEGEGEFWLGNDYLHLLTQ-RGSVLRVELEDWAGNEAYAEY-HFRVGSEAEGYAL-QV 755

  Fly   197 GEFTGDAGDSMI------------HNRNQNFSTFDRDNDGWHKNCAEEYVGAWWHLNCTYSNLFG 249
            ..:.|.|||::|            || |..|||||||.|.|.:||||.|.|.||:.||..:||.|
Human   756 SSYEGTAGDALIEGSVEEGAEYTSHN-NMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNG 819

  Fly   250 IYVKG------DEGQYFQWKGIVWHSWRTESYSYKVMQMMVRP 286
            ||..|      :...|....|:||.|:|...||.:.::|.:||
Human   820 IYYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAVRMKIRP 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9500	NP_609018.3	FReD	76..287	CDD:238040	90/240 (38%)
FGA	NP_000499.1	Alpha-chain polymerization, binding distal domain of another fibrin gamma chain	36..38
		Fib_alpha	50..187	CDD:285864
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..460
		Fibrinogen_aC	445..509	CDD:288972
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..638		15/73 (21%)
		FReD	630..863	CDD:238040	89/237 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910