Protein Alignment ppk14 and ASIC3

DIOPT Version :10

• Sequence 1: NP_609017.2
• Gene: ppk14 / 33887
• FlyBaseID: FBgn0031803
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_064717.1
• Gene: ASIC3 / 9311
• HGNCID: 101
• Length: 549
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 118/526 - (22%)
• Similarity: 197/526 - (37%)
• Gaps: 130/526 - (24%)

  Fly    45 YISRSHIHGLYLLFLPSMRRRMRVLWALALICA-CTVLFHVSYLLGDRYHNKQFQTIVAHAHASI 108
            :.|...:|||..:|.|......|.:||.|::.: .|.|:.|:..:  ||: ::|....|......
Human    20 FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERV--RYY-REFHHQTALDERES 81

  Fly   109 HHIAFPVVIICNKNRLNWSRLPEI------KSLYNITPSQDELFDRIL---TAYDGF----SFHK 160
            |.:.||.|.:||.|.|..|||...      .:|..:.|::...|.|.|   .|..||    :|..
Human    82 HRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDM 146

  Fly   161 FNAFDSLLGESLDELNHLNFTEIVIQMSWRCDEILRDCHWQTASRDCCKLFRPRRLP-----LGY 220
            ...: :..|.|||::                   |.||.::  .:.|    .|....     :|.
Human   147 AQLY-ARAGHSLDDM-------------------LLDCRFR--GQPC----GPENFTTIFTRMGK 185

  Fly   221 CLAFNE----LEKRRGTETGINTGLLLRLLLREGQHAPGNSGLKGFWLTVVESSVWFGFPIEVVP 281
            |..||.    .|....|..|:..||.:.|.:::.::.|       .|....|:....|..:::
Human   186 CYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLP-------VWRDNEETPFEVGIRVQI-- 241

  Fly   282 HS--------RTNVAVTAVYHYF---DESTLS-LPSSWRHCVM-----DYE-EESEHFRT---LE 325
            ||        :..:.|:..|..|   .:..|| ||..|..|..     :|| |.|:...:   ..
Human   242 HSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSP 306

  Fly   326 GQKYMLENCQAECQQRYLLRYCNCTVDLFYPPSNYPACRLKDLPCLAAHNHLLQNFEQPGEHPYV 390
            ...|.|..|:..|:.||:.|.|.|.  :.|.|.:.|.|..:.....|              ||.:
Human   307 SPPYTLMGCRLACETRYVARKCGCR--MVYMPGDVPVCSPQQYKNCA--------------HPAI 355

  Fly   391 H---REESGLVCECLHNCKSLTLLTDM---------------RK-SVQQPWLQPNSSAIESMWLN 436
            .   |::|   |.|.:.|.|.....::               || :..:.::..|..|     |:
Human   356 DAMLRKDS---CACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLA-----LD 412

  Fly   437 VYFKKPSMLVYKTNLIYTWVDLIVSFGGICQLCLGCSIISLIEFVFFALY----KVPQLYWER-F 496
            ::|:..:....:....|...:|:...||...|.:|.|:::::|.:.:...    ||...:|.| .
Human   413 IFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQH 477

  Fly   497 SNEHRS 502
            |..|.|
Human   478 SQRHSS 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk14	NP_609017.2	ASC	45..483	CDD:459966	111/500 (22%)
ASIC3	NP_064717.1	ENaC	20..534	CDD:273304	118/526 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..307		4/21 (19%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	447..449		1/1 (100%)