DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk14 and ASIC3

DIOPT Version :9

Sequence 1:	NP_609017.2	Gene:	ppk14 / 33887	FlyBaseID:	FBgn0031803	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_064717.1	Gene:	ASIC3 / 9311	HGNCID:	101	Length:	549	Species:	Homo sapiens

Alignment Length:	526	Identity:	118/526 - (22%)
Similarity:	197/526 - (37%)	Gaps:	130/526 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 YISRSHIHGLYLLFLPSMRRRMRVLWALALICA-CTVLFHVSYLLGDRYHNKQFQTIVAHAHASI 108
            :.|...:|||..:|.|......|.:||.|::.: .|.|:.|:..:  ||: ::|....|......
Human    20 FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERV--RYY-REFHHQTALDERES 81

  Fly   109 HHIAFPVVIICNKNRLNWSRLPEI------KSLYNITPSQDELFDRIL---TAYDGF----SFHK 160
            |.:.||.|.:||.|.|..|||...      .:|..:.|::...|.|.|   .|..||    :|..
Human    82 HRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDM 146

  Fly   161 FNAFDSLLGESLDELNHLNFTEIVIQMSWRCDEILRDCHWQTASRDCCKLFRPRRLP-----LGY 220
            ...: :..|.|||::                   |.||.::  .:.|    .|....     :|.
Human   147 AQLY-ARAGHSLDDM-------------------LLDCRFR--GQPC----GPENFTTIFTRMGK 185

  Fly   221 CLAFNE----LEKRRGTETGINTGLLLRLLLREGQHAPGNSGLKGFWLTVVESSVWFGFPIEVVP 281
            |..||.    .|....|..|:..||.:.|.:::.::.|       .|....|:....|..:::
Human   186 CYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLP-------VWRDNEETPFEVGIRVQI-- 241

  Fly   282 HS--------RTNVAVTAVYHYF---DESTLS-LPSSWRHCVM-----DYE-EESEHFRT---LE 325
            ||        :..:.|:..|..|   .:..|| ||..|..|..     :|| |.|:...:   ..
Human   242 HSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSP 306

  Fly   326 GQKYMLENCQAECQQRYLLRYCNCTVDLFYPPSNYPACRLKDLPCLAAHNHLLQNFEQPGEHPYV 390
            ...|.|..|:..|:.||:.|.|.|.  :.|.|.:.|.|..:.....|              ||.:
Human   307 SPPYTLMGCRLACETRYVARKCGCR--MVYMPGDVPVCSPQQYKNCA--------------HPAI 355

  Fly   391 H---REESGLVCECLHNCKSLTLLTDM---------------RK-SVQQPWLQPNSSAIESMWLN 436
            .   |::|   |.|.:.|.|.....::               || :..:.::..|..|     |:
Human   356 DAMLRKDS---CACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLA-----LD 412

  Fly   437 VYFKKPSMLVYKTNLIYTWVDLIVSFGGICQLCLGCSIISLIEFVFFALY----KVPQLYWER-F 496
            ::|:..:....:....|...:|:...||...|.:|.|:::::|.:.:...    ||...:|.| .
Human   413 IFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQH 477

  Fly   497 SNEHRS 502
            |..|.|
Human   478 SQRHSS 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk14	NP_609017.2	ASC	45..483	CDD:279230	111/500 (22%)
ASIC3	NP_064717.1	ASC	20..534	CDD:295594	118/526 (22%)
ASIC3	NP_064717.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..307		4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920