Protein Alignment ppk14 and SCNN1G

DIOPT Version :9

• Sequence 1: NP_609017.2
• Gene: ppk14 / 33887
• FlyBaseID: FBgn0031803
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001030.2
• Gene: SCNN1G / 6340
• HGNCID: 10602
• Length: 649
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 133/611 - (21%)
• Similarity: 206/611 - (33%)
• Gaps: 201/611 - (32%)

  Fly    24 PLAPVNTKSEIQRAWTLLIDSYISRSHIHGLYLLFLPSMRRRMRVLW------ALALI---CACT 79
            |.||  |..|:.| |      |...::.||...:.: |..|..|:||      |:|||   ||..
Human    20 PQAP--TIKELMR-W------YCLNTNTHGCRRIVV-SRGRLRRLLWIGFTLTAVALILWQCALL 74

  Fly    80 VLFHVSYLLGDRYHNKQFQTIVAHAHASIHHIAFPVVIICNKNRLNWSRL------------PEI 132
            |.              .|.|:..........:.||.|.|||.|...:|.:            ..:
Human    75 VF--------------SFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREAL 125

  Fly   133 KSLYNITPS----------------QDELFDRI-LTAYD-------------------GFSFHKF 161
            ||||....|                |.....|| |..:|                   |...||.
Human   126 KSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKA 190

  Fly   162 N-----------AFDSLLGESLD-----------------ELNHLNF-----TEIVIQMSWRCDE 193
            :           .|.....::.|                 :|:::|.     .|..|.||:..:|
Human   191 SNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEE 255

  Fly   194 ILRDCHWQTASRDCCKLFRPRRLPL-GYCLAFNELEKRRGTET---GINTGLLLRLLLREGQHAP 254
            :|..|.:...|.| .:.|.....|: |.|..||..|......|   |...||.:.|.:.|.::.|
Human   256 LLVTCFFDGVSCD-ARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNP 319

  Fly   255 ---GNSGLKGFWLTVVESSVWFGFPIEVVPHSRTNVAVTAVYHYFDESTLSLPSSWRHCVMDYEE 316
               .::|.|    .::.....:.|..:|.....|.:..:...|..:...||.|.|  .|..|..:
Human   320 FLVSSTGAK----VIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYS--QCTEDGSD 378

  Fly   317 ESEHFRTLEGQKYMLENCQAECQQRYLLRYCNCTVDLFY-----PPSNYPACRLKDLPCLAAHNH 376
            ..  .|.:....|.|:.|...|.|..::..|.|..   |     |.:||         |
Human   379 VP--IRNIYNAAYSLQICLHSCFQTKMVEKCGCAQ---YSQPLPPAANY---------C------ 423

  Fly   377 LLQNFEQPGEHP-------YVHR----EESGLVCECLHNC--KSLTLLTDMRK---SVQQPWLQP 425
               |::|   ||       .:||    ||.|....|...|  |..||.|.:.:   .|.:.||.|
Human   424 ---NYQQ---HPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLP 482

  Fly   426 NSSAIESMWLN------------VYFK---KPSMLVYKTNLIYTWVDLIVSFGGICQLCLGCSII 475
            ..:..:...:|            :::|   :.|::....|.|..   |:.:|||...|.:.||::
Human   483 VLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEM---LLSNFGGQLGLWMSCSVV 544

  Fly   476 SLIEFV------FFALYKVPQLYWER 495
            .:||.:      ||::  :.:..|::
Human   545 CVIEIIEVFFIDFFSI--IARRQWQK 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk14	NP_609017.2	ASC	45..483	CDD:279230	123/576 (21%)
SCNN1G	NP_001030.2	ENaC	24..630	CDD:273304	130/605 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820