DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk14 and SCNN1G

DIOPT Version :10

Sequence 1:NP_609017.2 Gene:ppk14 / 33887 FlyBaseID:FBgn0031803 Length:504 Species:Drosophila melanogaster
Sequence 2:NP_001030.2 Gene:SCNN1G / 6340 HGNCID:10602 Length:649 Species:Homo sapiens


Alignment Length:611 Identity:133/611 - (21%)
Similarity:206/611 - (33%) Gaps:201/611 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 PLAPVNTKSEIQRAWTLLIDSYISRSHIHGLYLLFLPSMRRRMRVLW------ALALI---CACT 79
            |.||  |..|:.| |      |...::.||...:.: |..|..|:||      |:|||   ||..
Human    20 PQAP--TIKELMR-W------YCLNTNTHGCRRIVV-SRGRLRRLLWIGFTLTAVALILWQCALL 74

  Fly    80 VLFHVSYLLGDRYHNKQFQTIVAHAHASIHHIAFPVVIICNKNRLNWSRL------------PEI 132
            |.              .|.|:..........:.||.|.|||.|...:|.:            ..:
Human    75 VF--------------SFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREAL 125

  Fly   133 KSLYNITPS----------------QDELFDRI-LTAYD-------------------GFSFHKF 161
            ||||....|                |.....|| |..:|                   |...||.
Human   126 KSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKA 190

  Fly   162 N-----------AFDSLLGESLD-----------------ELNHLNF-----TEIVIQMSWRCDE 193
            :           .|.....::.|                 :|:::|.     .|..|.||:..:|
Human   191 SNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEE 255

  Fly   194 ILRDCHWQTASRDCCKLFRPRRLPL-GYCLAFNELEKRRGTET---GINTGLLLRLLLREGQHAP 254
            :|..|.:...|.| .:.|.....|: |.|..||..|......|   |...||.:.|.:.|.::.|
Human   256 LLVTCFFDGVSCD-ARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNP 319

  Fly   255 ---GNSGLKGFWLTVVESSVWFGFPIEVVPHSRTNVAVTAVYHYFDESTLSLPSSWRHCVMDYEE 316
               .::|.|    .::.....:.|..:|.....|.:..:...|..:...||.|.|  .|..|..:
Human   320 FLVSSTGAK----VIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYS--QCTEDGSD 378

  Fly   317 ESEHFRTLEGQKYMLENCQAECQQRYLLRYCNCTVDLFY-----PPSNYPACRLKDLPCLAAHNH 376
            ..  .|.:....|.|:.|...|.|..::..|.|..   |     |.:||         |      
Human   379 VP--IRNIYNAAYSLQICLHSCFQTKMVEKCGCAQ---YSQPLPPAANY---------C------ 423

  Fly   377 LLQNFEQPGEHP-------YVHR----EESGLVCECLHNC--KSLTLLTDMRK---SVQQPWLQP 425
               |::|   ||       .:||    ||.|....|...|  |..||.|.:.:   .|.:.||.|
Human   424 ---NYQQ---HPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLP 482

  Fly   426 NSSAIESMWLN------------VYFK---KPSMLVYKTNLIYTWVDLIVSFGGICQLCLGCSII 475
            ..:..:...:|            :::|   :.|::....|.|..   |:.:|||...|.:.||::
Human   483 VLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEM---LLSNFGGQLGLWMSCSVV 544

  Fly   476 SLIEFV------FFALYKVPQLYWER 495
            .:||.:      ||::  :.:..|::
Human   545 CVIEIIEVFFIDFFSI--IARRQWQK 568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk14NP_609017.2 ASC 45..483 CDD:459966 123/576 (21%)
SCNN1GNP_001030.2 ENaC 24..630 CDD:273304 130/605 (21%)
Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000269|PubMed:30251954, ECO:0000269|PubMed:32729833 135..221 10/85 (12%)
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:17502380 623..627
Blue background indicates that the domain is not in the aligned region.

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