Protein Alignment ppk14 and ASIC4

DIOPT Version :10

• Sequence 1: NP_609017.2
• Gene: ppk14 / 33887
• FlyBaseID: FBgn0031803
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: XP_054198812.1
• Gene: ASIC4 / 55515
• HGNCID: 21263
• Length: 666
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 119/510 - (23%)
• Similarity: 192/510 - (37%)
• Gaps: 121/510 - (23%)

  Fly    44 SYISRSHIHGLYLLFLPSMRRRMRVLWALALICACTVLFHVSYLLGDRYHNKQFQTIVAHAHASI 108
            ::.|.|.:|||.....|......|.||||||:.:.....:.:..|...|..:..  :||...|:.
Human   171 TFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPH--LVAMDPAAP 233

  Fly   109 HHIA-FPVVIICNKNRLNWSRL--PEIKSLYNIT--PSQDELFDRILTAYDGFSFHKFNAFDSLL 168
            ..:| ||.|.:||.||...|.|  .:|..|.|:|  |.:|.         ||   |:........
Human   234 APVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDR---------DG---HRAAGLRYPE 286

  Fly   169 GESLDELNHLNFTEIVIQMSWRCDEILRDC----HWQTASRDCCKLFRPRRLPLGYCLAFN---- 225
            .:.:|.||....     |::    ::|:.|    |..:||.     |.......|.|..||
Human   287 PDMVDILNRTGH-----QLA----DMLKSCNFSGHHCSASN-----FSVVYTRYGKCYTFNADPR 337

  Fly   226 -ELEKRRGTETGINTGLLLRLLLREGQHAPGNSGLKGFWLTVVESSVWFGFPIEVVPHS------ 283
             .|..|.|   |:.:||.:.|.:::.::.|       .|....|:|...|..:::  ||
Human   338 SSLPSRAG---GMGSGLEIMLDIQQEEYLP-------IWRETNETSFEAGIRVQI--HSQEEPPY 390

  Fly   284 --RTNVAVTAVYHYF---DESTLS-LPSSWRHCVMDYE-EESEHFRTLEG-QKYMLENCQAECQQ 340
              :....|:..:..|   .|..|: ||..|.:|..:.| .|.|    |:| ..|.:..|:..|::
Human   391 IHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPE----LQGYSAYSVSACRLRCEK 451

  Fly   341 RYLLRYCNCTV------DLFYPPSNYPACRLKDLPCLAAHNHLLQNFEQPGEHPYVHREESGLVC 399
            ..:|:.|:|.:      :...||:.|..|.          :|.|.:.....|.|          |
Human   452 EAVLQRCHCRMVHMPGNETICPPNIYIECA----------DHTLDSLGGGPEGP----------C 496

  Fly   400 ECLHNCKSLTLLTDMRKSVQQPWLQPNSSA---------------IESMWLNVYFKKPSMLVYKT 449
            .|...|.    ||...|.:....:....||               ...:.|:|:|:..:....:.
Human   497 FCPTPCN----LTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQ 557

  Fly   450 NLIYTWVDLIVSFGGICQLCLGCSIISLIEFVFFALYKVPQLYWERFSNEHRSNK 504
            ...|....|:...||...|.:|.||::|:|.:.: :|:|.   |:|.....|..|
Human   558 RAAYGLSALLGDLGGQMGLFIGASILTLLEILDY-IYEVS---WDRLKRVWRRPK 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk14	NP_609017.2	ASC	45..483	CDD:459966	113/486 (23%)
ASIC4	XP_054198812.1	ENaC	167..615	CDD:273304	119/510 (23%)