Protein Alignment ppk14 and ASIC5

DIOPT Version :9

• Sequence 1: NP_609017.2
• Gene: ppk14 / 33887
• FlyBaseID: FBgn0031803
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 103/531 - (19%)
• Similarity: 177/531 - (33%)
• Gaps: 140/531 - (26%)

  Fly    43 DSYISRSHIHGLYLLFLPSMRRRMRVLWALALICACTVLFHVSYLLGDRYHNKQFQTIVAHAHAS 107
            |..||.| .||::.: :.:..:..||||.:.::.:.:::....|:....|......|.:...:
Human    40 DFAISTS-FHGIHNI-VQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQY-- 100

  Fly   108 IHHIAFPVVIICNKNRLN-------------WSRLPEIKSLYNITPSQD---ELFDRILTAYDGF 156
            :..:.||.|..||.||..             |..:.::..|..||.:..   |..| ...::..|
Human   101 VEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATD-FAASHQNF 164

  Fly   157 SFHKF---NAFDSLLGESLDELNHLNFTEIVIQMSWRCDEILRDCHW---QTASRDCCKLFRPRR 215
            |..:|   ..|            :||            :..|.||.:   ..:.:|...:|
Human   165 SIVEFIRNKGF------------YLN------------NSTLLDCEFFGKPCSPKDFAHVF---- 201

  Fly   216 LPLGYCLAFNELEKRRGTETGINTGLLLRLLLREGQHAPGNSGLKGFWLTVVESSVWF------- 273
            ...|.|..||..|..:.......:|..|.||....|.|..::...||    |::.:.|
Human   202 TEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAFTDNPALGF----VDAGIIFVIHSPKK 262

  Fly   274 -------GFPIEVVPHSRTNVAVTAVYHYFDESTLSLPSSWRHCVMDYEEESEHFRTLEGQKYML 331
                   |....|..|:|..:......|.      ..|  |..|       :.:.:......|..
Human   263 VPQFDGLGLLSPVGMHARVTIRQVKTVHQ------EYP--WGEC-------NPNIKLQNFSSYST 312

  Fly   332 ENCQAECQQRYLLRYCNCTVDLFYPP-------SNYPAC--------RLKDLPCLAAHNH----L 377
            ..|..||:.:::.:.|.| |....|.       ..|.:|        ..|||..:..||.    .
Human   313 SGCLKECKAQHIKKQCGC-VPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVS 376

  Fly   378 LQNFEQPGEHPYVHREESGLVCECLHNCKSLTLLTDMRKSVQQ--PWLQPNSSAIESMWLNVYFK 440
            .:..|.|....|          ....:.|:|..|:   |.:.|  .:::.|...||..:.::.:|
Human   377 CEEIEYPATISY----------SSFPSQKALKYLS---KKLNQSRKYIRENLVKIEINYSDLNYK 428

  Fly   441 KPSMLVYKTNLIYTWVDLIVSFGGICQLCLGCSIISLIEFV-----------FFALYKVPQL-YW 493
                 :.:.....:..:|:...||...|..|.|:|::||.:           .|.|.|:.:: .|
Human   429 -----ITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLLKISEMTQW 488

  Fly   494 ERFSNEHRSNK 504
            ......|..||
Human   489 TPPPQNHLGNK 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk14	NP_609017.2	ASC	45..483	CDD:279230	95/505 (19%)
ASIC5	NP_059115.1	ASC	41..466	CDD:279230	95/495 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820