DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk14 and asic2

DIOPT Version :9

Sequence 1:	NP_609017.2	Gene:	ppk14 / 33887	FlyBaseID:	FBgn0031803	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_005164179.1	Gene:	asic2 / 407669	ZFINID:	ZDB-GENE-040513-4	Length:	564	Species:	Danio rerio

Alignment Length:	541	Identity:	124/541 - (22%)
Similarity:	198/541 - (36%)	Gaps:	144/541 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RIRRQDQNPLAPVNTKSEIQRAWTLLIDSYISRSHIHGLYLLFLPSMRRRMRVLWALALICACTV 80
            |.||:...|..|   :.::.|    |..:.:||:.:|||..:..||.....|..|.:| .|.|..
Zfish    45 RARRRHTRPGTP---RDDLSR----LTVALLSRTRLHGLRHICSPSNSLSRRAFWMIA-FCTCLG 101

  Fly    81 LFHVSYLLGDRYHNKQFQTIVAHAHASIH-----HIAFPVVIICNKNRLNWSRLPEIKSLYNITP 140
            |. :|:......|...|.|     |..:|     .:|||.|.|||.|.:.         ||::|.
Zfish   102 LL-LSWSSNRLLHWLAFPT-----HTRVHTEWAKELAFPTVTICNNNPVR---------LYHLTK 151

  Fly   141 S------------------QDELFDRILTAYDGFSFHKFNAFDSLLGESLDELNHLNFTEIVIQM 187
            |                  :..:.|.:.....|: |.|.:.|...|.....|...|.|.:   ::
Zfish   152 SDLYFAGHWLGLLLANRTARPLVLDLLQDDRRGW-FSKLSDFRLFLPPRRFEGTSLEFMD---RL 212

  Fly   188 SWRCDEILRDCHWQTASRDC-CKLFRPRRLPLGYCLAFNELEKRRGTET----GINTGLLLRLLL 247
            ..:.:::|..|.::  ...| ...|.......|.|..||..|:.:...|    |...||.:.|.:
Zfish   213 GHQLEDMLLACKYR--GEPCGAHNFSTVFTRYGKCYMFNAAEEGKTLRTTMKGGTGNGLEIMLDI 275

  Fly   248 REGQHAPGNSGLKGFWLTVVESSVWFGFPIE----------------VVPHSRTNVAVTAVYHYF 296
            ::.::.|       .|....|::...|..::                |.|..:|.||.
Zfish   276 QQDEYLP-------VWGETEETAFEAGVRVQIHSQAEPPFVHELGFGVAPGFQTFVAT------- 326

  Fly   297 DESTLS-LPSSWRHCVMDYEEESEHFRTLEG---QKYMLENCQAECQQRYLLRYCNCTVDLFYPP 357
            .|..|: ||..|..||.         |.|:.   |.|.:..|:.||:.||::..|||.  :.|.|
Zfish   327 QEQRLTYLPPPWGECVS---------RALDSGLFQVYSVSACRIECETRYIVENCNCR--MVYMP 380

  Fly   358 SNYPAC---RLKDL--PCLAAHNHLLQNFEQPGEHPYVHREESGLVCECLHNCKSLTLLTDMRKS 417
            .:.|.|   :.||.  |.|||.:.:                 .|..|.|...|.    :|...|.
Zfish   381 GDSPYCTPEQYKDCAEPALAALSAV-----------------EGTNCICRSPCN----MTRYNKE 424

  Fly   418 VQQPWLQPNSSA--IESMW-------------LNVYFKKPSMLVYKTNLIYTWVDLIVSFGGICQ 467
            :....:...:||  :|..:             |:|:|:..:....:....|....|:...||...
Zfish   425 LSMVKIPSKTSARYLEKKFNRSEKYITDNILVLDVFFEALNYETIEQKKAYEVAGLLGDIGGQMG 489

  Fly   468 LCLGCSIISLIEFVFFALYKV 488
            |.:|.||::|:|...:| |:|
Zfish   490 LFIGASILTLLELFDYA-YEV 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk14	NP_609017.2	ASC	45..483	CDD:279230	114/505 (23%)
asic2	XP_005164179.1	ASC	71..538	CDD:295594	115/508 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920