Protein Alignment ppk14 and ASIC2

DIOPT Version :9

• Sequence 1: NP_609017.2
• Gene: ppk14 / 33887
• FlyBaseID: FBgn0031803
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 106/528 - (20%)
• Similarity: 183/528 - (34%)
• Gaps: 165/528 - (31%)

  Fly    46 ISRSHIHGLYLLFLPSMRRRM-------------RVLWALALICACTVLFHVSY-LLGDRYHNKQ 96
            :||:.:|||         |.|             |.||.||.   ||     |: ||.....|:.
Human    61 LSRAKLHGL---------RHMCAGRTAAGGSFQRRALWVLAF---CT-----SFGLLLSWSSNRL 108

  Fly    97 FQTIVAHAHASIH-----HIAFPVVIICNKNRLNWSRL----------------------PEIKS 134
            ...:...:|..:|     .:.||.|.:||.|.|.:.||                      |.:..
Human   109 LYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSE 173

  Fly   135 LYNITPSQDELFDRILTAYDGFSFHKF---NAFDSLLGESLDELNHLNFTEIVIQMSWRCDEILR 196
            |......:.:.|.::.      .|..|   ..|:.:....:|.|.|            :.:::|.
Human   174 LLRGDEPRRQWFRKLA------DFRLFLPPRHFEGISAAFMDRLGH------------QLEDMLL 220

  Fly   197 DCHWQTASRDCCKLFRPRRL-----PLGYCLAFNELEKRRGTET----GINTGLLLRLLLREGQH 252
            .|.::.      :|..|...     ..|.|..||..|..:...|    |...||.:.|.:::.::
Human   221 SCKYRG------ELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEY 279

  Fly   253 APGNSGLKGFWLTVVESSVWFGFPIEVVPHSRT--------NVAVTAVYHYF---DESTLS-LPS 305
            .|       .|....|::...|..:::  ||::        ...|...:..|   .|..|: ||.
Human   280 LP-------IWGETEETTFEAGVKVQI--HSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPP 335

  Fly   306 SWRHCVMDYEEESEHFRTLEGQKYMLENCQAECQQRYLLRYCNCTVDLFYPPSNYPACRLKDLPC 370
            .|..| ...|...:.|..     |.:..|:.:|:.||::..|||.  :.:.|.:.|.|
Human   336 PWGEC-RSSEMGLDFFPV-----YSITACRIDCETRYIVENCNCR--MVHMPGDAPFC------- 385

  Fly   371 LAAHNHLLQNFEQPGEHPYVHREESGLVCE-----CLHNCKSLTLLTDMRKSVQQPWLQPNSSA- 429
                        .|.:|........||:.|     ||  |::...||...|.:....:...:||
Human   386 ------------TPEQHKECAEPALGLLAEKDSNYCL--CRTPCNLTRYNKELSMVKIPSKTSAK 436

  Fly   430 -IESMW-------------LNVYFKKPSMLVYKTNLIYTWVDLIVSFGGICQLCLGCSIISLIEF 480
             :|..:             |:::|:..:....:....|....|:...||...|.:|.||::::|
Human   437 YLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILE- 500

  Fly   481 VFFALYKV 488
            :|..:|::
Human   501 LFDYIYEL 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk14	NP_609017.2	ASC	45..483	CDD:279230	104/521 (20%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	104/525 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920