DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk14 and Asic2

DIOPT Version :9

Sequence 1:	NP_609017.2	Gene:	ppk14 / 33887	FlyBaseID:	FBgn0031803	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_006532059.1	Gene:	Asic2 / 11418	MGIID:	1100867	Length:	596	Species:	Mus musculus

Alignment Length:	559	Identity:	109/559 - (19%)
Similarity:	185/559 - (33%)	Gaps:	194/559 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ISRSHIHGLYLLFLPSMRRRM-------------RVLWALALICACTVLFHVSYLLGDRYHNKQF 97
            :||:.:|||         |.|             |.||.||.   ||.|    .||.....|:..
Mouse    61 LSRTKLHGL---------RHMCAGRTAAGGSFQRRALWVLAF---CTSL----GLLLSWSSNRLL 109

  Fly    98 QTIVAHAHASIH-----HIAFPVVIICNKNRLNWSRL----------------------PEIKSL 135
            ..:...:|..:|     .:.||.|.:||.|.|.:.||                      |.:..|
Mouse   110 YWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSEL 174

  Fly   136 YNITPSQDELFDRILTAYDGFSFHKF---NAFDSLLGESLDELNHLNFTEIVIQMSWRCDEILRD 197
            ......:.:.|.::.      .|..|   ..|:.:....:|.|.|            :.:::|..
Mouse   175 LRGDEPRRQWFRKLA------DFRLFLPPRHFEGISAAFMDRLGH------------QLEDMLLS 221

  Fly   198 CHWQ--------TASRDCCKLFRPRRLP-----------------------------LGYCLAFN 225
            |.::        .:|..|     |.|.|                             .|.|..||
Mouse   222 CKYRGELCGPHNFSSVSC-----PPREPALSDPALPRSPEALRWAPGTGHQAPVFTKYGKCYMFN 281

  Fly   226 ELEKRRGTET----GINTGLLLRLLLREGQHAPGNSGLKGFWLTVVESSVWFGFPIEVVPHSRT- 285
            ..|..:...|    |...||.:.|.:::.::.|       .|....|::...|..:::  ||::
Mouse   282 SGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLP-------IWGETEETTFEAGVKVQI--HSQSE 337

  Fly   286 -------NVAVTAVYHYF---DESTLS-LPSSWRHCVMDYEEESEHFRTLEGQKYMLENCQAECQ 339
                   ...|...:..|   .|..|: ||..|..| ...|...:.|..     |.:..|:.:|:
Mouse   338 PPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGEC-RSSEMGLDFFPV-----YSITACRIDCE 396

  Fly   340 QRYLLRYCNCTVDLFYPPSNYPACRLKDLPCLAAHNHLLQNFEQPGEHPYVHREESGLVCE---- 400
            .||::..|||.  :.:.|.:.|.|                   .|.:|........||:.|
Mouse   397 TRYIVENCNCR--MVHMPGDAPFC-------------------TPEQHKECAEPALGLLAEKDSN 440

  Fly   401 -CLHNCKSLTLLTDMRKSVQQPWLQPNSSA--IESMW-------------LNVYFKKPSMLVYKT 449
             ||  |::...||...|.:....:...:||  :|..:             |:::|:..:....:.
Mouse   441 YCL--CRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQ 503

  Fly   450 NLIYTWVDLIVSFGGICQLCLGCSIISLIEFVFFALYKV 488
            ...|....|:...||...|.:|.||::::| :|..:|::
Mouse   504 KKAYEVAALLGDIGGQMGLFIGASILTILE-LFDYIYEL 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk14	NP_609017.2	ASC	45..483	CDD:279230	107/552 (19%)
Asic2	XP_006532059.1	ASC	64..590	CDD:383197	107/556 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920