Protein Alignment ppk14 and asic2

DIOPT Version :10

• Sequence 1: NP_609017.2
• Gene: ppk14 / 33887
• FlyBaseID: FBgn0031803
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: XP_004918663.1
• Gene: asic2 / 100492214
• XenbaseID: XB-GENE-6033380
• Length: 541
• Species: Xenopus tropicalis
• Alignment Length: 547
• Identity: 118/547 - (21%)
• Similarity: 198/547 - (36%)
• Gaps: 143/547 - (26%)

  Fly     6 TEKETRVVADRIRRQDQNPLAPVNTKSEIQRAWTLLIDSYISRSHI--HGLYLLFLPSMRRRMRV 68
            |..:..||:.:           .:|:::.:.|.:|     .|..||  |||..:..|.:..|.|.
 Frog    19 TRTDAHVVSQK-----------CHTRTQHRHALSL-----PSLQHIKLHGLKYICSPKLAFRHRT 67

  Fly    69 LWALALICACTVLFHVSYLLGDRYHNKQFQTIVAHAHASIH-----HIAFPVVIICNKNRLNWSR 128
            .|.||..  .::.|.:|:     ..|:....:...:|..:.     .:|||.|..||.|.:.:.|
 Frog    68 FWFLAFF--TSLGFFLSW-----SSNRLLYWLSFPSHTRVQLEWSKELAFPAVTFCNNNPVRFHR 125

  Fly   129 LPEIKSLY-----------NIT--PSQDELF--DRILTAYDGFSFHKF---NAFDSLLGESLDEL 175
            |.: ..||           |.|  |...||.  ||.........|..|   ..||.:....:|.|
 Frog   126 LSK-SDLYFAGYWLGLLFANRTARPMLAELLPEDRRKWFQKLADFRLFLPPRNFDGISVGFMDRL 189

  Fly   176 NHLNFTEIVIQMSWRCDEILRDCHWQTASRDCCKLFRPRRLP-----LGYCLAFNELEKRRGTET 235
            .|            :.:::|..|.::   .:.|   .|....     .|.|..||..:..|...|
 Frog   190 GH------------QLEDMLLSCKYR---GEAC---GPHNFSTVFTRYGKCYMFNSGQDGRPVLT 236

  Fly   236 ----GINTGLLLRLLLREGQHAPGNSGLKGFWLTVVESSVWFGFPIEVVPHSRT--------NVA 288
                |...||.:.|.:::.::.|       .|....|::...|..:::  ||::        ...
 Frog   237 TVKGGAGNGLEIMLDIQQDEYLP-------IWGDTEETTFEAGVKVQI--HSQSEPPFIQELGFG 292

  Fly   289 VTAVYHYF---DESTLS-LPSSWRHCVMDYEEESEHFRTLEGQKYMLENCQAECQQRYLLRYCNC 349
            |...:..|   .|..|: |||.|..|... |..|:.|..     |.:..|:.:|:.||::..|.|
 Frog   293 VAPGFQTFVATQEQRLTYLPSPWGACRFS-ELGSDFFPV-----YSISACRIDCETRYIVENCGC 351

  Fly   350 TV-----DL-FYPPSNYPACRLKDLPCLAAHNHLLQNFEQPGEHPYVHREESGLVCECLHNC--- 405
            .:     |. |..|..|..|....|..||                    |:.|..|.|...|
 Frog   352 KMVHMPGDAPFCTPEQYKECAEPALDLLA--------------------EKDGGNCVCTIPCNVT 396

  Fly   406 ---KSLTLLTDMRKSVQQPWLQPNSSAIES------MWLNVYFKKPSMLVYKTNLIYTWVDLIVS 461
               |.|:::....|: ...:|:...:..|.      :.|:|:|:..:....:....|....|:..
 Frog   397 RYNKELSMVKIPSKT-SAKYLEKKFNKSEKYILDNILVLDVFFEALNYETIEQRKAYEVAGLLGD 460

  Fly   462 FGGICQLCLGCSIISLIEFVFFALYKV 488
            .||...|.:|.||::::| :|..:|::
 Frog   461 IGGQMGLFIGASILTILE-LFDYIYEL 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk14	NP_609017.2	ASC	45..483	CDD:459966	110/501 (22%)
asic2	XP_004918663.1	ENaC	49..497	CDD:273304	109/501 (22%)