DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk14 and asic2

DIOPT Version :9

Sequence 1:	NP_609017.2	Gene:	ppk14 / 33887	FlyBaseID:	FBgn0031803	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_004918663.1	Gene:	asic2 / 100492214	XenbaseID:	XB-GENE-6033380	Length:	541	Species:	Xenopus tropicalis

Alignment Length:	547	Identity:	118/547 - (21%)
Similarity:	198/547 - (36%)	Gaps:	143/547 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TEKETRVVADRIRRQDQNPLAPVNTKSEIQRAWTLLIDSYISRSHI--HGLYLLFLPSMRRRMRV 68
            |..:..||:.:           .:|:::.:.|.:|     .|..||  |||..:..|.:..|.|.
Frog    19 TRTDAHVVSQK-----------CHTRTQHRHALSL-----PSLQHIKLHGLKYICSPKLAFRHRT 67

  Fly    69 LWALALICACTVLFHVSYLLGDRYHNKQFQTIVAHAHASIH-----HIAFPVVIICNKNRLNWSR 128
            .|.||..  .::.|.:|:     ..|:....:...:|..:.     .:|||.|..||.|.:.:.|
Frog    68 FWFLAFF--TSLGFFLSW-----SSNRLLYWLSFPSHTRVQLEWSKELAFPAVTFCNNNPVRFHR 125

  Fly   129 LPEIKSLY-----------NIT--PSQDELF--DRILTAYDGFSFHKF---NAFDSLLGESLDEL 175
            |.: ..||           |.|  |...||.  ||.........|..|   ..||.:....:|.|
Frog   126 LSK-SDLYFAGYWLGLLFANRTARPMLAELLPEDRRKWFQKLADFRLFLPPRNFDGISVGFMDRL 189

  Fly   176 NHLNFTEIVIQMSWRCDEILRDCHWQTASRDCCKLFRPRRLP-----LGYCLAFNELEKRRGTET 235
            .|            :.:::|..|.::   .:.|   .|....     .|.|..||..:..|...|
Frog   190 GH------------QLEDMLLSCKYR---GEAC---GPHNFSTVFTRYGKCYMFNSGQDGRPVLT 236

  Fly   236 ----GINTGLLLRLLLREGQHAPGNSGLKGFWLTVVESSVWFGFPIEVVPHSRT--------NVA 288
                |...||.:.|.:::.::.|       .|....|::...|..:::  ||::        ...
Frog   237 TVKGGAGNGLEIMLDIQQDEYLP-------IWGDTEETTFEAGVKVQI--HSQSEPPFIQELGFG 292

  Fly   289 VTAVYHYF---DESTLS-LPSSWRHCVMDYEEESEHFRTLEGQKYMLENCQAECQQRYLLRYCNC 349
            |...:..|   .|..|: |||.|..|... |..|:.|..     |.:..|:.:|:.||::..|.|
Frog   293 VAPGFQTFVATQEQRLTYLPSPWGACRFS-ELGSDFFPV-----YSISACRIDCETRYIVENCGC 351

  Fly   350 TV-----DL-FYPPSNYPACRLKDLPCLAAHNHLLQNFEQPGEHPYVHREESGLVCECLHNC--- 405
            .:     |. |..|..|..|....|..||                    |:.|..|.|...|
Frog   352 KMVHMPGDAPFCTPEQYKECAEPALDLLA--------------------EKDGGNCVCTIPCNVT 396

  Fly   406 ---KSLTLLTDMRKSVQQPWLQPNSSAIES------MWLNVYFKKPSMLVYKTNLIYTWVDLIVS 461
               |.|:::....|: ...:|:...:..|.      :.|:|:|:..:....:....|....|:..
Frog   397 RYNKELSMVKIPSKT-SAKYLEKKFNKSEKYILDNILVLDVFFEALNYETIEQRKAYEVAGLLGD 460

  Fly   462 FGGICQLCLGCSIISLIEFVFFALYKV 488
            .||...|.:|.||::::| :|..:|::
Frog   461 IGGQMGLFIGASILTILE-LFDYIYEL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk14	NP_609017.2	ASC	45..483	CDD:279230	110/501 (22%)
asic2	XP_004918663.1	ASC	49..497	CDD:383197	109/501 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010