Protein Alignment ppk7 and asic1a

DIOPT Version :10

• Sequence 1: NP_609016.2
• Gene: ppk7 / 33886
• FlyBaseID: FBgn0031802
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_999955.1
• Gene: asic1a / 791696
• ZFINID: ZDB-GENE-040513-2
• Length: 501
• Species: Danio rerio
• Alignment Length: 516
• Identity: 118/516 - (22%)
• Similarity: 187/516 - (36%)
• Gaps: 131/516 - (25%)

  Fly    38 FGKRTTIHGLDRLLSAKASRWERFVWLCTFVSAFLGAVYVCLILSARYNAAHFQTVVDSTRFPVY 102
            |...:|:||:..:.|.:....:..:|:..|:|:....:|||:.....|......|.:|....||
Zfish    26 FAHTSTLHGISHIFSYEKITAKCCLWVVFFLSSLTFLMYVCIDRIQFYLEYPHVTKLDEITTPV- 89

  Fly   103 RIPFPVITICNRNRLNWQR------------LAEAKSRFLANGSNSAQQELFELIVGTYDDAYFG 155
             :.||.:||||.|.:.:.|            ||...||.....::..::.:.|::....|
Zfish    90 -MVFPAVTICNLNSIRFSRITRNDLYHAGELLALLNSRHEVREAHLVEESVMEVLKSKTD----- 148

  Fly   156 HFQSFERLRNQPTELLNYVNFSQVVDFMTWRCNELLAECLWRHHAYDCC--EIFSKRRSKNGLCW 218
             |:||:.......|..|.....         ..::|..|.:|...   |  |.||...::.|.|:
Zfish   149 -FRSFKPRHFNMWEFYNRTGHD---------IKDMLLSCQFRGSP---CRPEDFSVVFTRYGKCY 200

  Fly   219 AFNSLETEEGRRMQLLDPMWPWRTGSAGPM-SALSVRVLIQPAKH---WPGHRETNAMKGIDVMV 279
            .|||.||            .|.|....|.| :.|.:.:.||..::   |....|::...||.|.:
Zfish   201 TFNSGET------------GPPRVSVKGGMGNGLEIMLDIQQDEYLPVWGESDESSFEAGIKVQI 253

  Fly   280 ----TEPFVWHNNPFFVAANTETTMEIEPVIYFYDNDTRGVRSDQRQCVFDDEHNS-KDFKSLQG 339
                ..||: ....|.||...:|.:..:               :||.........| |.......
Zfish   254 HSQDEPPFI-DQLGFGVAPGFQTFVSCQ---------------EQRLVYLPAPWGSCKSTPPSSD 302

  Fly   340 Y--VYMIENCQSECHQEYLVRYCNCTMDLLFPPGQ--------YRSCRAQDLLCLAEHNDLLIYS 394
            |  .|.|..|:::|...|||..|||.|  :..||.        |:.|....|       |.|:.:
Zfish   303 YFRAYSISACRTDCETRYLVENCNCRM--VHMPGDAPYCTPVLYKECAHPAL-------DFLVET 358

  Fly   395 HNPGEKEFVRNQFQGMSCKCFRNCYSLNYISDVRPAFLP--------------PDVYANNSYVDL 445
                :.::         |.|...|....|..::....:|              .:.|...:.:.|
Zfish   359 ----DSDY---------CSCETPCNITRYSKELSFVKIPSKASVKYLAKKYSKSEKYITENVMVL 410

  Fly   446 DVHF---RFETIMVYRTSLVFGWVDLMVSFGGIAGLFLGCSLISGMEL--------AYFLC 495
            ||.|   .:|||...:...|.|   |:...||..|||:|.|:::.:||        .|.||
Zfish   411 DVFFEALNYETIEQRKAYEVAG---LLGDIGGQMGLFIGASILTILELFDYLYEVMKYRLC 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk7	NP_609016.2	ASC	38..493	CDD:459966	115/512 (22%)
asic1a	NP_999955.1	ENaC	23..469	CDD:273304	118/516 (23%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:Q1XA76	446..448		1/1 (100%)